Sr 95531

Manufactured by Hello Bio

Sourced in United Kingdom

SR-95531 is a selective GABAA receptor antagonist. It acts primarily by blocking the GABAA receptor, a key inhibitory neurotransmitter receptor in the central nervous system.

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Lab products found in correlation

Tpmpa, by Bio-Techne (1 mentions) Mk 801, by Abcam (1 mentions) Cgp55845, by Bio-Techne (1 mentions) Jnj16259685, by Bio-Techne (1 mentions) Win 55, by Bio-Techne (1 mentions) Kynurenic acid, by Bio-Techne (1 mentions) Cyclothiazide, by Bio-Techne (1 mentions) Qx 314, by Bio-Techne (1 mentions) Am251, by Bio-Techne (1 mentions)

Spelling variants of this product

GABAzine (SR 95531 hydrobromide; (2 citations)

3 protocols using sr 95531

Antagonist Concentrations for Electrophysiology

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The following concentrations (in μM) of antagonists were used for experiments: 20 CNQX disodium salt (Hello Bio, UK), 100 TPMPA (Tocris Bioscience), and 5 SR-95531 (Hello Bio, UK). Antagonists were initially prepared as stock solutions in distilled water or DMSO in the case of CNQX. During experiments, drugs were freshly prepared from a stock solution in carboxygenated Ringer’s solution. All drug solutions were bath applied to the tissue for at least 5 min prior to recording.

Srivastava P., de Rosenroll G., Matsumoto A., Michaels T., Turple Z., Jain V., Sethuramanujam S., Murphy-Baum B.L., Yonehara K, & Awatramani G.B. (2022). Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells. eLife, 11, e81533.

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Caged Compounds for Cellular Signaling

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Caged-IP₃ was a generous gift from Hitoshi Morikawa, PhD (University of Texas, Austin, TX), who obtained it from Kamran Khodakhah, PhD (Albert Einstein School of Medicine, Bronx, NY). DMNPE-4 caged-Ca²⁺ was a generous gift from Graham Ellis-Davies, PhD (GM053395, Ichan School of Medicine at Mount Sinai, NY, NY). CGP-55845, JNJ-16259685, and MPEP were obtained from Tocris (Minneapolis, MN). Apamin was obtained from Calbiochem (San Diego, CA). NBQX and MK801 were obtained from Abcam (Cambridge, MA). SR-95531 was obtained from Hello Bio (Princeton, NJ). The remaining compounds were obtained from Sigma-Aldrich (St. Louis, MO).

Kramer P.F, & Williams J.T. (2016). Calcium Release from Stores Inhibits GIRK. Cell reports, 17(12), 3246-3255.

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Pharmacological Modulation of Synaptic Mechanisms

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SR95531, DL-APV, and strychnine were purchased from Hello-Bio. AM-251, WIN 55, 212-2, QX-314, cyclothiazide, and kynurenic acid were purchased from Tocris. ZX1 was purchased from STREM Chemicals.

Kalappa B.I, & Tzounopoulos T. (2017). Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc. eNeuro, 4(1), ENEURO.0011-17.2017.

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