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Glibenclamide gli

Manufactured by Merck Group
Sourced in United States

Glibenclamide (Gli) is a laboratory reagent used for research purposes. It is a hypoglycemic agent that can be used to study insulin secretion and glucose homeostasis.

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2 protocols using glibenclamide gli

1

Pharmacological Modulation of Vascular Tone

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Etomidate was purchased from Nhwa (Nhwa Pharmaceutical, Jiangsu, CHN). Intralipid was purchased from SSPC (Sino-Swed Pharmaceutical, Jiangsu, CHN). Phenylephrine hydrochloride (PE), KCl, acetylcholine chloride (ACh), sodium nitroprusside (SNP), L-NAME, indomethacin (Indo), iberiotoxin, 4-aminopyridine (4-AP) and glibenclamide (Gli) were purchased from Sigma (St. Louis, MO, USA). Gli were dissolved in ethanol (final concentration of ethanol in a tissue bath ≤ 0.5%, with no influence on PE-induced contraction). Phenylephrine hydrochloride, etomidate, ACh, SNP, 4-AP and L-NAME were dissolved in distilled water. Indo was dissolved in 4% (wt/vol) NaHCO3.
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2

Analytical Reagents and Solvents Protocol

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Analytical
grade solvents (CHCl3, EtOAc, and n-hexane)
and high-performance liquid
chromatography (HPLC) grade solvents (MeOH and H2O) were
purchased from J.T. Baker (Avantor, Radnor, PA). Analytical reagents
[glibenclamide (GLI), metformin (MTF), glucose, nicotinamide (NA),
streptozotocin (STZ), and Tween 80] were purchased from Sigma-Aldrich
(St. Louis, MO).
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