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Tim trio mr

Manufactured by Siemens
Sourced in Germany

The Tim Trio MR is a laboratory equipment product offered by Siemens. It is a multi-purpose device designed for various analytical and research applications. The core function of the Tim Trio MR is to perform thermal analysis measurements.

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7 protocols using tim trio mr

1

Standardized MRI Protocols for Brain Imaging

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Standardized MRI protocols were used for brain structural and functional scans on 3 T Siemens Tim Trio MR scanner. The high resolution isotropic 3D T1 structural images were acquired in sagittal orientation using a MPRAGE GRAPPA protocol and imaging parameters of repetition time (TR) = 2,300 ms, echo time (TE) = 2.98 ms, flip angle (FA) = 9o, field of view (FOV) = 240 × 256 mm2, and voxel size = 1 × 1 × 1 mm3. The rs-fMRI BOLD images were acquired in axial direction using a T2* weighted single shot EPI sequence with imaging parameters of TR = 2,400 ms, TE = 25 ms, FA = 80o, FOV = 222 × 222 mm2, voxel size = 3.294 × 3.294 × 3.3 mm3, with a total of 210 EPI volumes. The participants were instructed to remain quiet, with their eyes open and not fall asleep throughout the rs-fMRI scan.
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2

Structural and Diffusion MRI Acquisition

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The MRI data were collected at a 3T Siemens Tim Trio MR scanner at BCH when the subject was 4 years old. No sedation or medication was used during the MRI scan. The imaging protocol consisted of structural and diffusion-weighted sequences. The first structural sequence was a T1-weighted high-resolution magnetization-prepared rapid-acquisition gradient-echo (MPRAGE) acquisition, which used volumetric EPI navigators for real time motion correction [voxel size (mm) = 1 × 1 × 1; field of view (FOV) = 19.2 cm; echo time (TE) = 1.74 ms; repetition time (TR) = 2530 ms; flip angle = 7°]. The second structural sequence was a T2-weighted turbo spin-echo FLAIR sequence (TSE-FLAIR) [voxel size (mm) = 0.6250 × 0.6250 × 4.0000; FOV = 25.6 cm; TE = 1.37 ms; TR = 9000 ms; flip angle = 150°]. The diffusion sequence (prescribed axially) used echo-planar (EP) readouts [voxel size (mm) = 1.7 × 1.7 × 2.0; FOV = 22 cm; TE = 78 ms; TR = 8100 ms; flip angle = 90°; 30 gradient diffusion directions at b = 1000 s/mm2; five acquisitions with b = 0 s/mm2].
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3

Functional and Structural MRI Acquisition

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Functional images and structural T1-weighted images were obtained using a 3 T Siemens Tim Trio MR scanner (Siemens Healthcare, Erlangen, Germany), equipped with a 12 channel head coil. A gradient-echo EPI (echo planar imaging) sequence was used for the functional MRI (TE 30 ms, flip angle 90°, TR 2.79 s, whole brain coverage with 42 slices, acquisition bandwidth 116 kHz, 2 mm slice thickness, 1 mm inter-slice gap, in-plane resolution 3 × 3 mm). Geometric distortions were characterized by a B0 field-map scan. For further details, see Supplementary Materials.
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4

High-resolution Neuroimaging with FreeSurfer Analysis

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Neuroimaging was performed on a 3T Siemens Tim Trio MR scanner (Siemens AG, Erlangen Germany) with a 12-channel head coil. A high-resolution, 3-dimensional, sagittal, magnetization-prepared rapid gradient echo scan (MPRAGE) T1 scan was acquired (repetition time [TR] = 2400ms, echo time (TE) = 3.16 ms, flip angle = 8°, inversion time = 1000 ms, voxel size = 1×1×1 mm3 voxels, 256×256×256 acquisition matrix, 162 slices).
Structural volumes were obtained using the FreeSurfer software suite (v5.1) (Martinos Center, Harvard University, Boston, MA, USA; http://surfer.nmr.mgh.harvard.edu). Briefly, this automated software program transforms MPRAGE images of an individual into a template space with the skull stripped and the brain segmented into white matter, gray matter, and ventricles. Cortical and subcortical image segmentation was completed using a surface deformation program [81 (link)–82 (link)]. Reviewers trained in FreeSurfer processing confirmed the quality of segmentation and volumes. Manual edits were performed only when outliers were identified. These manually-corrected scans were then reanalyzed. Regional brain volumes were normalized with respect to total intracranial volume (ICV) using a least square residual regression model across the entire cohort in order to account for possible variations in head size [36 (link), 83 (link)–86 (link)].
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5

Multimodal Brain Imaging Protocol for Comprehensive Neurological Assessment

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MRI scanning was performed at the MR Research Center of the University of Pittsburgh. A 3-Tesla Siemens Tim Trio MR scanner was used, with a Siemens 12-channel head coil. Three series of MR images were analyzed for the current study, all acquired in the axial orientation as follows: 1. T1-weighted magnetization-prepared rapid gradient echo (MPRAGE), TR (repetition time) = 2300 ms, TE (echo time) =3.43 ms, inversion time (TI) = 900 ms, FA (flip angle) = 9 deg, slice thickness = 1 mm, FOV (field of view) = 256*224 mm, voxel size = 1 mm*1mm, and slices = 176; 2. T2-weighted fluid-attenuated inversion recovery (FLAIR), TR = 9160 ms, TE = 89 ms, TI = 2500 ms, FA = 150 deg, FOV = 256*212 mm, slice thickness=3 mm, slices=48, and voxel size= 1 mm*1 mm; 3. diffusion tensor imaging (DTI), single-short spin-echo sequence, TR = 5300 ms, TE = 88 ms, TI = 2500 ms, FA = 90 deg, FOV = 256*256 mm, two diffusion values of b=0 and 1000 s/mm, 12 diffusion directions, four repeats; 40 slices; voxel size= 2 mm*2 mm; slice thickness = 3mm, and GRAPPA (radial generalized auto-calibrating partially parallel acquisitions) =2.
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6

Quantification of White Matter Hyperintensities using MRI

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MRI scanning was performed at the MR Research Center of the University of Pittsburgh. A 3T Siemens Tim Trio MR scanner was used, with a Siemens 12-channel head coil. Two series of MR images were analyzed for the current study: a Magnetization-prepared rapid gradient echo (MPRAGE) T1-weighted sequence and T2-weighted Fluid-attenuated inversion recovery (FLAIR) sequence. MPRAGE images were acquired in the axial plane: TR=2300 ms; TE=3.43 ms; TI=900 ms; Flip angle= 9 deg; Slice Thickness=1mm; FOV= 256*224 mm; voxel size= 1mm*1mm; matrix size= 256*224; and number of slices=176. FLAIR images were acquired in the axial plane: TR=9160 ms; TE=89 ms; TI=2500 ms; FA=150 deg; FOV= 256*212 mm; slice thickness=3 mm; matrix size=256*240; number of slices=48 slices; and voxel size= 1mm*1mm.
The WMH volume was obtained from the MPRAGE and T2-weighted FLAIR image using an automated method for quantification and localization of WMH.21 (link) The WMH quantification was done using a fuzzy connected algorithm.22 (link) The total WMH volume was normalized by total brain volume.
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7

Brain PET/MR Imaging Protocol

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The measurements were performed with a clinical brain PET/MR imaging system (BrainPET, Tim Trio MR; Siemens Healthcare). The PET scanner (16) was mounted inside a 3-tesla MR scanner. The spatial resolution in the center was 2.3, 3.1, and 2.6 mm in full width at half maximum in the x, y, and z directions, respectively (16) . Acquired list-mode data were reconstructed using an ordinary Poisson ordered-subsets expectation maximization 3-dimensional algorithm (6 iterations and 16 subsets) (17) . The z-axis of the scanner was defined as aligned with the magnetic field. Additional measurements were performed with a clinical PET/CT (18) Hi-Rez Biograph 16 (Siemens Medical Solutions) with a spatial resolution of about 4 mm.
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