Scintillation glass vials

MOX was purchased from Fischer Scientific (Hanover Park, IL, USA). MOX-HCL was purchased from Combi-Blocks, Inc. (San Diego, CA, USA). Oleic acid, Tween^® 80, and glycerin were purchased from Spectrum Pharmaceuticals (Henderson, NV, USA). Slide-A-Lyzer™ MINI dialysis devices (10 K molecular weight cutoff) were obtained from Fischer Scientific (Hampton, NH, USA). Hydroxypropyl methylcellulose (HPMC K4M) was received as a gift from Colorcon^® (Colorcon, Inc., West Point, PA, USA). Polyvinylpyrrolidone (PVP, Plasdone™ K29/32) was purchased from Ashland Global (Wilmington, DE, USA). Solvents used for analysis were of high-performance liquid chromatography (HPLC) grade and were purchased from Fischer Scientific (Hampton, NH, USA). All membrane filters were purchased from MilliporeSigma (St. Louis, MO, USA). Centrifuge tubes, HPLC vials, and scintillation glass vials were acquired from Fischer Scientific (Hampton, NH, USA). Cation-adjusted Mueller Hinton Broth 2 was purchased from MilliporeSigma (St. Louis, MO, USA).

Cannabidiol (CBD) derived from hemp was used in this study and was a gift from ElSohly Laboratories, Inc. (Oxford, MS, USA). Optical rotation, melting point test, mass spectroscopy, and nuclear magnetic resonance spectroscopy studies were performed to ensure that this investigation was carried out with the (-) normal CBD isomer. Poloxamer 407 NF grade, sesame oil NF grade, Carbopol^® 940 NF grade, glycerin NF grade, and Tween^® 80 (Polysorbate 80) NF grade were purchased from Spectrum Chemicals (New Brunswick, NJ, USA). All other chemicals, including Vitamin E-d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS), were purchased from Fisher Scientific (St. Louis, MO, USA). Solvents used for the instrumental analysis were of high-performance liquid chromatography (HPLC) grade and were purchased from Fischer Scientific (St. Louis, MO, USA). Centrifuge tubes, scintillation glass vials, and Slide-A-Lyzer™ MINI Dialysis Devices (10 K molecular weight cutoff) were purchased from Fischer Scientific (Hampton, NH, USA). Screw top clear class A (Type I) borosilicate glass HPLC vials (12 × 32 mm, 2.0 mL) with pre-slit silicone septa were purchased from Waters (Waters, Milford, CA, USA).