MR measurements were conducted at the beginning and the end of the study using a 3.0 T Ingenia MRI system (Philips Healthcare, Best, the Netherlands) with a dStream torso coil. Single-voxel MR spectroscopy (Point RESolved Spectroscopy [PRESS]) was used to measure total hepatic and muscle fat fractions [17 (link)]. Chemical shift encoding-based water-fat imaging (mDixon) was used to measure pancreatic fat fraction, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and waist circumference. Pancreatic fat content was measured in duplicates, and the mean was used to minimise intra-observer variability. A single 10 mm thick transverse section acquired at the middle of L3 vertebra was used for quantification of VAT, SAT and waist circumference [18 (link)]. All MR data were analysed blinded to treatment.
Ingenia mri system
Manufactured by Philips
Sourced in Netherlands
The Ingenia MRI system is a magnetic resonance imaging (MRI) device manufactured by Philips. It is designed to generate high-quality images of the human body using strong magnetic fields and radio waves. The Ingenia MRI system is a versatile and reliable diagnostic tool used by healthcare professionals to assist in the detection and management of various medical conditions.
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Lab products found in correlation
12 protocols using ingenia mri system
1
Comprehensive MRI-based Body Composition Analysis
2
Multiparametric MRI Protocols for Prostate Examination
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Images were acquired with a 3T multicoil Ingenia MRI system (Philips). mpMRI protocols include T2-weighted (T2w), DWI, ADC maps and dynamic contrast enhanced MRI (DCE-MRI) sequences. In this regard, it is worth mentioning that, for scientific aims, all DWI sequences were previously acquired employing nine different b-values and ADC maps referred to all of them, accordingly. Patient preparation required fasting 6 h before the examination, bowel preparation to be performed 2 h before the examination and emptying of the bladder. To reduce peristaltic motion, 1 mL of scopolamine–butylbromide (Buscopan, Boehringer Ingelheim, Ingelheim, Germany) was administered in a slow bolus infusion at 20 mg/mL, diluted in 10 mL of saline solution. Table 2 reports details of DWI protocols for the seventy-six patients included in this study.
3
Quantifying Hepatic Steatosis by MRI
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Hepatic steatosis was evaluated by magnetic resonance imaging (MRI) using a 3.0 T Ingenia MRI system (Philips Healthcare) with a dStream torso coil and evaluated at baseline and following 6 weeks’ diet intervention. Total hepatic fat fractions were measured by single-voxel MR spectroscopy (Point RESolved Spectroscopy [PRESS]) [31 (link), 32 (link)]. These data have been published previously [26-29 (link)].
4
Whole-Brain fMRI Imaging Protocol
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The main experiments and the localizer scans were conducted at the Renown Health hospital (Reno, NV) using a 3T Philips Ingenia MRI system equipped with a 32-channel digital SENSE head coil. Continuous whole-brain BOLD signals were collected using T2*-weighted interleaved, echo-planar functional images (TE = 40 ms, TR = 2 s, flip angle = 71°, 32 axial slices, 3 mm2, 2 mm thickness, 1 mm gap, matrix size = 128 × 128, field of view = 240 × 240). Dummy scans were collected for a minimum of 10 s at the beginning of every run to allow for stabilization of the magnetic field. High-resolution anatomical images obtained using a 3-D T1-weighted pulse sequence (TE = 4.60 ms, TR = 3.0 s, flip angle = 8°, resolution = 1 × 1 × 1 mm, matrix size = 256 × 256) and were used for anatomical reconstruction of the cortical hemisphere surfaces.
5
Multimodal MRI Acquisition Protocol
6
Functional MRI of Brain Activity
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Scans were acquired using a 3 T Philips Ingenia MRI system (Philips, Best, The Netherlands) with a 32-channel head coil. To obtain functional images, a single-shot echo-planar imaging (EPI) sequence sensitive to blood oxygenation level-dependent contrast was used, and an additional EPI scan with opposite phase polarity was acquired for distortion correction with the following scan parameters: TR/TE = 730/30 ms; flip angle = 55°; multiband factor = 4; SENSE = 1.8; field of view = 240 × 240 × 132 mm; voxel size = 2.5 × 2.5 × 2.75 mm; 48 slices. A T1-weighted magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence was used for anatomical referencing with the following scan parameters: TR/TE = 7/3 ms; flip angle = 9°; field of view = 240 × 180 × 256 mm; voxel size = 1 mm isotropic; 180 slices. For every participant the last seven volumes were removed because they were obtained beyond the task duration.
7
Cardiac MRI Examination of Ventricular Function
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Patients were scanned on commercially available 1.5T CMR scanners (Gyroscan ACS-NT/Intera MRI system; Philips Medical Systems, Best, Netherlands, or Siemens Avanto; Siemens Healthcare, Erlangen, Germany), or a 3.0-T CMR scanner (Ingenia MRI system; Philips Medical Systems, Best, Netherlands). Standard cine images in long- and short-axis views were acquired during expiratory breath holds using a balanced steady-state free precession sequence. Left ventricular (LV) and RV mass, volumes and EF were measured on the consecutive short-axis cine images (from the base to apex). Late gadolinium enhancement (LGE) imaging was performed 10–15 min after administration of a gadolinium-based contrast agent (Gadovist 0.1 mmol/kg or Dotarem 0.2 mmol/kg), and LGE presence and localization were visually evaluated.
8
Multi-modal MRI Assessment of Adiposity
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All MR measurements were performed using a 3.0T Philips Ingenia MRI system with a 32-channel Philips SENSE XL torso coil. Two-point modified Dixon scans and an in-house automated segmentation algorithm (MATLAB R2020a; The MathWorks Inc., Natick, MA, USA) were used to quantify volumes of ScAT, VAT, and VAT-to-total abdominal adipose tissue (TAT; ScAT + VAT) ratio. 24 The 1 H-MRS spectra were acquired using a Stimulated Echo Acquisition Mode-localized, single-voxel sequence. Single breathholds, with and without water suppression, were used for the assessment of liver PDFF, while high-sensitivity spectra were acquired over six breath-holds for determination of hepatic lipid composition. All 1 H-MRS spectra were processed and analysed offline by an experienced researcher (S.J.B.) in a blinded fashion using a home-developed MATLAB script (MATLAB R2020a; The Math-Works Inc). Liver PDFF and hepatic lipid composition indices of saturation (SI), unsaturation (UI), and polyunsaturation (PUI) were subsequently calculated using externally validated equations. 11, 22 The 1 H-MRS acquisition and post-processing procedures are described in further detail in the Supplementary Methods S1.
9
MRI Imaging Protocol for Stem Cell Therapy Evaluation
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All patients underwent a baseline magnetic resonance imaging (MRI) scanning less than a week before stem cell injection and repeated at 12 months post-treatment. Scanning was performed on a 3T Philips Ingenia MRI system (Philips, Netherlands). The imaging protocol included the following imaging sequences: high-resolution 3D-T1-weighted Fast-Field Echo with 1-mm three isotropic spatial resolution; reconstruction matrix = 240 × 240; inversion time = 1,000 ms; flip angle = 8°; TR = 8.08 ms; TE = 3.7 ms; turbo factor =148; Shot-to-Shot Interval = 3,000 ms; scan time = 5:86 min. 3D-T2-weighted, Turbo-Spin Echo, fluid-attenuated inversion recovery (FLAIR) with 0.74 × 0.74 × 3 mm3 spatial resolution; reconstruction matrix = 336 × 336; inversion time = 1,650 ms; flip angle = 90°; TR = 4,800 ms; TE = 309 ms; turbo factor = 177; scan time = 5:32 min.
White matter T2 lesion segmentation was performed as described by Al-Radaideh et al.44 (link)
White matter T2-hyperintense lesion volume measurements for each patient were obtained using a semi-automated segmentation technique based on the Fuzzy Connectedness algorithm in Jim software (Jim version 7; Xinapse Systems, Northants, England)45
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White matter T2 lesion segmentation was performed as described by Al-Radaideh et al.44 (link)
White matter T2-hyperintense lesion volume measurements for each patient were obtained using a semi-automated segmentation technique based on the Fuzzy Connectedness algorithm in Jim software (Jim version 7; Xinapse Systems, Northants, England)45
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10
Structural MRI Acquisition and Preprocessing
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Structural MRI acquisition and preprocessing has been previously described in detail (35 (link)). Briefly, T1-weighted (T1w) brain images were obtained with a 3.0T Philips Ingenia MRI system (1 mm isotropic resolution; TR, 8.1 ms; TE, 3.7 ms; flip angle, 8°; SENSE factor 2). FSL software (64 (link)) was used for bias field correction, tissue type segmentation and non-linear registration to the MNI152 template, using a lesion mask to improve registration for participants with stroke. Lesioned voxels in the native-space T1w image were temporarily filled with MNI template voxels (65 (link)) to enable automated structure labeling with FreeSurfer software (66 (link)). Lesioned voxels were then masked out of any structure labels.
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