The study was conducted as a randomized, parallel‐group, double‐blind, placebo‐controlled trial from May until December 2013 at the Departments of Medicine I and Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. Randomization was done using the permuted block method with a block size of four. A person not directly involved in study‐related procedures performed concealment of the respective drugs. Investigators involved in the study were not aware of the randomization codes, which were only broken after completion of the trial and of all laboratory analyses.
The trial was scheduled for two consecutive days. The study medication was administered in the fasting state once at day 1. Blood sampling was performed on day 1 before the first intake of the study medication and 2, 6, and 24 hours thereafter. The volunteers received 180 mg ticagrelor (Brilique/Brilinta; AstraZeneca, Södertälje, Sweden) together with 300 mg nonenteric coated aspirin (DAPT) or 180 mg ticagrelor together with placebo.
The trial was scheduled for two consecutive days. The study medication was administered in the fasting state once at day 1. Blood sampling was performed on day 1 before the first intake of the study medication and 2, 6, and 24 hours thereafter. The volunteers received 180 mg ticagrelor (Brilique/Brilinta; AstraZeneca, Södertälje, Sweden) together with 300 mg nonenteric coated aspirin (DAPT) or 180 mg ticagrelor together with placebo.