Discovery mr750 hdx

Patients underwent prostate MRI on a 3-T Discovery MR750 HDx or a 1.5-T MR450 scanner (GE Healthcare) using a 16–32-channel coil, respectively (Supplemental Tables 1 and 2). Axial fast spin-echo T1-weighted images of the pelvis, along with T2-weighted fast recovery fast spin-echo images of the prostate, were acquired in the axial, sagittal and coronal planes, with an axial slice thickness of 3–3.5 mm and a gap of 0–0.5 mm. Diffusion-weighted (DW) imaging was performed using a spin-echo echo-planar imaging pulse sequence (slice thickness 3–4 mm; gap 0 mm), with b values of 150 s/mm², 750 s/mm², 1000 s/mm² and 1400 s/mm² (additional 2000 s/mm² at 3 T) and apparent diffusion coefficient (ADC) maps automatically calculated. Dynamic contrast-enhanced (DCE) imaging was performed at baseline, but not in follow-up studies.

Patients underwent prostate MRI on either a 1.5 T (15%) MR450 or 3.0 T (85%) Discovery MR750 HDx (GE Healthcare, Waukesha/Chicago, IL, USA) with a 16-32 channel surface phased array coil. The protocol has been described in detail previously¹² (link); in brief, this comprised axial Fast Spin Echo T1-weighted images of the pelvis, along with T2-weighted Fast Recovery Fast Spin Echo images of the prostate acquired in the axial (slice thickness 3 mm; gap 0-1 mm), sagittal and coronal planes (Table 2). Axial diffusion-weighted imaging (DWI) was performed using a dual spin-echoplanar imaging pulse sequence with slice thickness 3-4 mm; gap 0 mm, and automated apparent diffusion coefficient maps. An additional small-FOV (24 × 12 cm) DWI series was performed at 1400 s mm⁻² (1.5 T) or 2000 s mm⁻² (3 T). Dynamic contrast-enhanced (DCE)-MRI was acquired as an axial 3D fast spoiled gradient echo sequence following bolus injection of Gadobutrol (Gadovist, Bayer HealthCare) via a power injector at a rate of 3 mL s⁻¹ (dose 0.1 mmol kg⁻¹) followed by a 25 mL saline flush, injection at 28 s/40 s, temporal resolution 7 s/10 s. The axial T2, DWI, and DCE sequences were matched in orientation, slice thickness, and gap.