Spss statistical software version 22.0 for windows

The IBM SPSS statistical software version 22.0 for Windows was used for statistical analyses. The Shapiro-Wilk test was used to assess normality. All RPL values in both groups conformed to a normal distribution (P > 0.05), while the other variables did not (P < 0.05). The variables that conformed to a normal distribution were presented as mean ± SD and the ones that did not as median (min-max). The Wilcoxon t-test and paired t-test were used for intragroup comparisons, while Student's t-test and the Mann–Whitney U test were used for intergroup comparisons. A P value <0.05 was considered significant.

Epidata 3.02 software (Epidata Association, Odense, Denmark) was used to establish a database, and the double entry method was used for data input and logic error detection. SPSS statistical software version 22.0 for Windows (IBM: Almon, NY, USA) was used for all data analysis. For descriptive statistics, t-test or Wilcoxon rank sum test were performed as appropriate after checking for normality, the chi-square test was used to evaluate differences between groups for the categorical variables. The gene counting method was used to calculate genotype and allele frequencies. The chi-square test was used to test for Hardy-Weinberg equilibrium, the odds ratio (OR) and 95% confidence interval (95% CI) and interactions between ApoA1 gene and types of obesity were assessed by binary logistic regression after controlling for potential confounders (sex, age, blood pressure, high TC, high TG, high LDL-C, smoker, drinker and FPG). P < 0.05 were considered statistically significant, the significance threshold was adjusted for multiple comparison tests according to Bonferroni correction, and set at P < 0.025 (0.05/2 = 0.025) when evaluating associations between genotypes in APOA1 gene and low HDL-C disease.