Ercc1 d 10

Manufactured by Santa Cruz Biotechnology

ERCC1 (D-10) is a primary antibody that targets the ERCC1 protein. ERCC1 is a DNA repair protein that plays a crucial role in the nucleotide excision repair (NER) pathway. This antibody can be used in various applications, such as western blotting, immunohistochemistry, and immunofluorescence, to detect and study the ERCC1 protein.

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Lab products found in correlation

Pcna fl 261, by Santa Cruz Biotechnology (1 mentions) Gapdh, by Merck Group (1 mentions) β actin, by Thermo Fisher Scientific (1 mentions) Goat anti mouse igg f ab 2, by Enzo Life Sciences (1 mentions)

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ERCC1 (5 citations)

2 protocols using ercc1 d 10

DNA Repair Protein Expression Analysis

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Performed as previously described(30 (link)). Primary antibodies ERCC1 (D-10) and PCNA (FL-261) were purchased from Santa Cruz; H2B (Ab1790) and Ku70 (Ab3114) were purchased from Abcam; XPF (Bethyl Labs A301-315); XPC (Novus NB100-477); XPA (NeoMarkers MS-650-P0); Cleabed-PARP (Cell Signaling 9541); and GAPDH (Millipore MAB374).

Mohni K.N., Kavanaugh G.M, & Cortez D. (2014). ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. Cancer research, 74(10), 2835-2845.

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Detailed Reagents and Antibodies Usage

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Trabectedin used in survival and COMET experiments was from Tecoland and in GLOE-seq experiments from Lucerna-Chem AG. Illudin S was from MGI Pharma. β-actin (catalog no. MA5-15739) was from Invitrogen. XPF antibodies were from Abcam (Catalog no. ab76948) and Santa Cruz (Catalog no. sc-136153). XPG was from Bethyl (catalog no. A301-484A). ERCC1 (D-10) was from Santa Cruz Biotechnology (Catalog no. sc-17809). Goat anti-rabbit IgG (Catalog no. ADI-SAB-300-J) and goat anti-mouse IgG F(ab’)2 (Catalog no. ADI-SAB-100-J) were from Enzo Life Sciences.

Son K., Takhaveev V., Mor V., Yu H., Dillier E., Zilio N., Püllen N.J., Ivanov D., Ulrich H.D., Sturla S.J, & Schärer O.D. (2024). Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes. Nature Communications, 15, 1388.

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