α msh

Manufactured by Abcam

Sourced in United Kingdom

α-MSH is a peptide hormone that acts as a potent agonist of the melanocortin receptor. It is involved in the regulation of pigmentation, energy homeostasis, and inflammation.

Automatically generated - may contain errors

Lab products found in correlation

Hs014, by Bio-Techne (1 mentions) Biie0246, by Bio-Techne (1 mentions) Bibo3304, by Bio-Techne (1 mentions) Psn632408, by Cayman Chemical (1 mentions) Synthetic melanin, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Merck Group (1 mentions) L tyrosine, by Merck Group (1 mentions) Dulbecco s modified eagle medium dmem, by Merck Group (1 mentions) Penicillin, by Merck Group (1 mentions) Streptomycin, by Merck Group (1 mentions) Triton x 100, by Merck Group (1 mentions) L dopa, by Nacalai Tesque (1 mentions)

2 protocols using α msh

Detailed Compound Solubilization and Storage

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BIBO3304 and BIIE0246 (Tocris Bioscience) were dissolved in 10% DMSO (at 1 mM) and stored at −20°C. Peptide stocks of LY211688 (Bachem Laboratories), α-MSH (Abcam), HS014 (Tocris Bioscience), NDP-α-MSH, ACTH and MT II (Phoenix Pharmaceuticals), VIP and PYY (Cambridge Bioscience) were dissolved in water, and aliquots stored at −20°C. PSN632408 (Cayman Chemical) was dissolved in 95% ethanol. All other compounds were of analytical grade (Sigma-Aldrich).

Panaro B.L., Tough I.R., Engelstoft M.S., Matthews R.T., Digby G.J., Møller C.L., Svendsen B., Gribble F., Reimann F., Holst J.J., Holst B., Schwartz T.W., Cox H.M, & Cone R.D. (2014). The Melanocortin-4 Receptor is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-Like Peptide 1 In Vivo. Cell metabolism, 20(6), 1018-1029.

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Melanin Synthesis Optimization

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Dulbecco's modified Eagle medium (DMEM), fetal bovine serum (FBS), penicillin, streptomycin, L-tyrosine, Triton-X 100, and synthetic melanin were obtained from Sigma-Aldrich (St. Louis, MO, USA). α-MSH was purchased from Abcam (Cambridge, UK). 4-Hydroxyphenyl β-Dglucopyranoside (arbutin) was purchased from Tokyo Chemical Industry (Tokyo, Japan). L-Dopa was purchased from Nacalai Tesque (Kyoto, Japan). All other chemicals were purchased from Fujifilm Wako Pure Chemical (Osaka, Japan) or Nacalai Tesque unless otherwise noted.

Nishi K., Mori M., Nakayama D., Sato J., Kim I., Kim M., Kim S., & Sugahara T. (2020). Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells. Biomedical Dermatology, 4(1).

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