4 hydroxyestrone

Manufactured by Merck Group

Sourced in United States

4-hydroxyestrone is a chemical compound that serves as a laboratory reagent. It is a metabolite of the female sex hormone estrone. This compound is commonly used in various research and analytical applications, but a detailed description of its core function cannot be provided while maintaining an unbiased and factual approach.

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Lab products found in correlation

3 protocols using 4 hydroxyestrone

Estrogen Metabolism Quantification

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Estrone(E1), 17β-estradiol(E2), estriol(E3), 2-hydroxyestrone(2-OHE1), 2-hydroxyestradiol(2-OHE2), 2-methoxyestrone(2-MeOE1), 2-methoxyestradiol(2-MeOE2), 4-hydroxyestrone(4-OHE1), 4-hydroxyestradiol(4-OHE2), 4-methoxyestrone(4-MeOE1), 4-methoxyestradiol(4-MeOE2), 16α-hydroxyestrone(16α-OHE1), d5-E2, dansyl chloride, Vitamin C, naloxone, naloxone-glucuronide, D-Saccharic acid 1,4-lactone monohydrate and UGPGA were supplied by Sigma-Aldrich (St. Louis, USA) and Steraloids (Rhode, USA).
Tamoxifen was obtained from Aladdin (Shanghai, China). Alamethicin was obtained from J&K Scientific. TRIzol® and PrimeScript RT Reagent Kit were purchased from TaKaRa Bio-technology Co., Ltd. (Beijing, China). Human liver microsomes (HLMs) were acquired from Rild Liver Disease Research Co., Ltd (Shanghai). All analytical solvents were of liquid chromatography (LC) - grade and were obtained from Sigma-Aldrich (St. Louis, USA) or Merck (Darmstadt, Germany).

Hao Z., Xu J., Zhao H., Zhou W., Liu Z., He S., Yin X., Zhang B., Wang Z, & Zhou X. (2022). The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation. BMC Pharmacology & Toxicology, 23, 33.

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Steroid and Lipid Quantification Protocol

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Cholesterol, E1, E2, E3, 4‐hydroxyestrone, 17α‐ethynylestradiol, HIP [also known as 3‐(7a‐methyl‐1,5‐dioxooctahydro‐1H‐inden‐4‐yl) propanoic acid] and testosterone were purchased from Sigma‐Aldrich (St. Louis, Missouri, USA). PEA was prepared as described by Chen et al., 2017 (link). The [3,4C‐¹³C]E1 (99%) was purchased from Cambridge Isotope Laboratories (Tewksbury, Massachusetts, USA). All other chemicals were of analytical grade and purchased from Honeywell Fluka (Loughborough, UK), Mallinckrodt Baker (Phillipsburg, NJ, USA), Merck (Darmstadt, Germany) and Sigma‐Aldrich.

Hsiao T., Lee T., Chuang M., Wang P., Meng M., Horinouchi M., Hayashi T., Chen Y, & Chiang Y. (2021). Identification of essential β‐oxidation genes and corresponding metabolites for oestrogen degradation by actinobacteria. Microbial Biotechnology, 15(3), 949-966.

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Synthesis and Characterization of Steroid Compounds

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Chemicals E1, E2, E3, 4-hydroxyestrone, 17α-ethynylestradiol, and HIP, also known as 3-(7a-methyl-1,5-dioxooctahydro-1H-inden-4-yl) propanoic acid, were purchased from Sigma-Aldrich (St.
Louis, Missouri, USA). PEA was prepared as described by Chen et al., 2017. The [3,4C-13 C]E1 (99%) was purchased from Cambridge Isotope Laboratories (Tewksbury, Massachusetts, USA).
All other chemicals were of analytical grade and purchased from Honeywell Fluka (Loughborough, UK), Mallinckrodt Baker (Phillipsburg, NJ, USA), Merck (Darmstadt, Germany), and Sigma-Aldrich (St. Louis, MO, United States).

Hsiao T., Lee T., Chuang M., Wang P., Meng M., Horinouchi M., Hayashi T., Chen Y., & Chiang Y. (2021). Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria.

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