Log In Sign up
The largest database of trusted experimental protocols

4 methoxybenzaldehyde

Manufactured by Merck Group
Visit Supplier
Sourced in United States

4-methoxybenzaldehyde is a chemical compound that functions as a reactive intermediate in organic synthesis. It is a pale yellow liquid with a distinct aroma. The molecular formula is C8H8O2 and the molar mass is 136.15 g/mol. This compound is commonly used as a precursor in the preparation of various organic compounds.

Automatically generated - may contain errors

Lab products found in correlation

Benzaldehyde, by Merck Group (5 mentions) 4 bromobenzaldehyde, by Merck Group (4 mentions) Ethyl acetate, by Xilong (3 mentions) N hexane, by Xilong (3 mentions) 4 chlorobenzaldehyde, by Merck Group (3 mentions) 4 methylbenzaldehyde, by Merck Group (3 mentions) 4 nitrobenzaldehyde, by Merck Group (2 mentions) 4 fluorobenzaldehyde, by Merck Group (2 mentions) 2 methoxybenzaldehyde, by Merck Group (2 mentions) Toluene, by Merck Group (2 mentions) Ammonium acetate, by Merck Group (2 mentions) Cyclopentanone, by Merck Group (2 mentions) Bu4nclo4, by Merck Group (2 mentions) 3 4 dimethoxybenzaldehyde, by Merck Group (2 mentions) 4 methylthio benzaldehyde, by Merck Group (2 mentions) Dc alufolien aluminiumoxid 60 f254 neutral, by Merck Group (2 mentions) 4 dimethylamino benzaldehyde, by Merck Group (2 mentions) 4 diethylaminobenzaldehyde, by Merck Group (2 mentions) Acetone, by Merck Group (2 mentions) Methylamine hydrochloride, by Merck Group (1 mentions)

16 protocols using 4 methoxybenzaldehyde

1

Purification and Characterization of Aldehydes

Check if the same lab product or an alternative is used in the 5 most similar protocols
All solvents used for FCC and reactions were purchased from POCH (Poland). Dichloromethane (DCM), ethyl acetate (AcOEt), hexane, toluene, diethyl ether (Et2O), and acetone were purified by fractional distillation.. All inorganic compounds were purchased from ChemPure (Poland) and used without prior purification. 2-Chloro-N,N-dimethylethylamine hydrochloride (99%), 1,3-acetonedicarboxylic acid (tech. grade), glutaraldehyde (50% wt.% in H2O), methylamine hydrochloride (≥98%), 4-fluorobenzaldehyde (98%), 4-chlorobenzaldehyde (97%), 4-bromobenzaldehyde (99%), 4-nitrobenzaldehyde (98%), 4-(trifluorometyl)benzaldehyde (97%), 4-methoxybenzaldehyde (≥98%), 3-methoxybenzaldehyde (≥97%), 3,4-dimethoxybenzaldehyde (99%), 3,4,5-trimethoxybenzaldehyde (98%), and vanillin (≥97%) were obtained from Merck and used without prepurification.
Pawelski D., Walewska A., Ksiezak S., Sredzinski D., Radziwon P., Moniuszko M., Gandusekar R., Eljaszewicz A., Lazny R., Brzezinski K, & Plonska-Brzezinska M.E. (2021). Monocarbonyl Analogs of Curcumin Based on the Pseudopelletierine Scaffold: Synthesis and Anti-Inflammatory Activity. International Journal of Molecular Sciences, 22(21), 11384.
+ Open protocol
+ Expand
2

Synthesis of Substituted Pyrano[2,3-c]pyrazoles

Check if the same lab product or an alternative is used in the 5 most similar protocols
Phenylhydrazine (97%), ethyl acetoacetate (99%), malononitrile (99%), 4-nitroBenzaldehyde (98%), furfural (99%), 5-nitro-2-furaldehyde (99%), 4-fluoroBenzaldehyde (98%), 4-chloroBenzaldehyde (97%), 4-bromoBenzaldehyde (99%), and p-toluenesulfonic acid monohydrate (TsOH) (ACS grade reagent, assay ≥ 98.5%) were purchased from Sigma-Aldrich. Benzaldehyde, 4-methylBenzaldehyde, 4-methoxyBenzaldehyde, aniline, ethanol, TLC (silica gel 60 F254), sulfuric acid (98%), hydrochloric acid (1 mol L−1), and ortho-phosphoric acid (85%) were purchased from Merck. Ethyl acetate (99.5%) and n-hexane (99.5%) were purchased from Xilong Chemical Co., Ltd (China).
Nguyen H.T., Dang P.H, & Tran P.H. (2023). A new and straightforward route to synthesize novel pyrazolo[3,4-b]pyridine-5-carboxylate scaffolds from 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. RSC Advances, 13(3), 1877-1882.
+ Open protocol
+ Expand
3

Flavone Synthesis from Benzaldehydes

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
The substrates 2-hydroxyacetophenone, 2-methoxybenzaldehyde, 3-methoxybenzaldehyde, 4-methoxybenzaldehyde, 2,5-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA). Flavones used in biotransformations were synthesized from those substrates (the reactions are described below). The resulting chalcones were used as substrates for the flavone synthesis and their NMR spectral data are identical to those previously published [34 (link),35 (link),36 (link)].
Łużny M., Tronina T., Kozłowska E., Dymarska M., Popłoński J., Łyczko J., Kostrzewa-Susłow E, & Janeczko T. (2020). Biotransformation of Methoxyflavones by Selected Entomopathogenic Filamentous Fungi. International Journal of Molecular Sciences, 21(17), 6121.
+ Open protocol
+ Expand
4

Spectroscopic Analysis of Organic Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols
1H and 13C{1H} NMR spectra were recorded on a Bruker Avance iii-500 spectrometer (Bruker BioSpin AG, Fällanden, Switzerland) at 298 K. The 1H and 13C NMR chemical shifts were referenced with respect to residual solvent peaks (δ TMS = 0). Electrospray ionization (ESI) mass spectra were recorded using a Shimadzu LCMS-2020 instrument (Shimadzu Schweiz GmbH, Reinach, Switzerland) samples were introduced as 200–800 μM solutions in MeCN with the addition of formic acid. PerkinElmer UATR Two (Perkin Elmer, Schwerzenbach, Switzerland) and Cary-5000 (Agilent Technologies Inc., Santa Clara, CA, USA) spectrometers were used to record FT-infrared (IR) and absorption spectra, respectively.
3-Acetylpyridine was purchased from Acros Organics (Chemie Brunschwig AG, Basel, Switzerland), and 4-methoxybenzaldehyde and Co(NCS)2 were bought from Sigma Aldrich (Steinheim, Germany). All chemicals were used as received.
Rocco D., Prescimone A., Klein Y.M., Gawryluk D.J., Constable E.C, & Housecroft C.E. (2019). Competition in Coordination Assemblies: 1D-Coordination Polymer or 2D-Nets Based on Co(NCS)2 and 4′-(4-methoxyphenyl)-3,2′:6′,3″-terpyridine. Polymers, 11(7), 1224.
+ Open protocol
+ Expand
5

Characterization of Organic Matter Interactions

Check if the same lab product or an alternative is used in the 5 most similar protocols
All chemicals were of analytical grade. Diethyl
phthalate (DEP, diethyl benzene-1,2-dicarboxylate), dibutyl phthalate
(DBP, dibutyl benzene-1,2-dicarboxylate), Rose Bengal (4,5,6,7-tetrachloro-2′,4′,5′,7′-tetraiodofluorescein,
dye content 95%), 3-methoxyacetophenone (3-MAP), 4-methoxybenzaldehyde
(4-MBA), 2-propanol-H8 (anhydrous), 2-propanol-D8 (anhydrous), hydrogen peroxide, dipotassium hydrogen phosphate (K2HPO4), potassium dihydrogen phosphate (KH2PO4), and 2,4,6-trimethyl-phenol (TMP) were purchased
from Sigma-Aldrich. The solvents n-hexane and dichloromethane
(HPLC grade) were supplied by the company Carl Roth. Pahokee Peat
humic acid (PPHA; 1R103H-2), Pahokee Peat fulvic acid (PPFA; 2S103F),
and Suwannee river natural organic matter (NOM, 2R101N) were purchased
from the International Humic Substances Society (IHSS), and Aldrich
humic acid (AHA) was derived from lignite and obtained from Sigma-Aldrich.
Pure water (18 MΩ cm) was used to prepare the solutions using
a Milli-Q system (Millipore, Billerica, MA).
Min N., Yao J., Li H., Chen Z., Pang W., Zhu J., Kümmel S., Schaefer T., Herrmann H, & Richnow H.H. (2023). Humic Substance Photosensitized Degradation of Phthalate Esters Characterized by 2H and 13C Isotope Fractionation. Environmental Science & Technology, 57(5), 1930-1939.
+ Open protocol
+ Expand
6

Cytochrome P450 Inhibitor Characterization

Check if the same lab product or an alternative is used in the 5 most similar protocols
Mefenamic acid (≥99%), tacrine (≥99%), carvedilol (≥98%), nifedipine (≥98%), ellipticine, α-naphthoflavone (≥97%), ticlopidine (≥99%), 1-naphtol (≥99%), 2-naphtol (≥98%), 4-methoxy-benzaldehyde (≥98%), 2-(p-tolyl)ethylamine (≥97%) were purchased from Sigma-Aldrich (Schnelldorf, Germany); phenacetin was obtained from Brocades-ACF (Maarssen, the Netherlands). 7-Methoxyresorufin was synthesized by the method of Burke and Mayer [28 (link)] and final purity was assessed to be higher than 95%.
Capoferri L., Verkade-Vreeker M.C., Buitenhuis D., Commandeur J.N., Pastor M., Vermeulen N.P, & Geerke D.P. (2015). Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation. PLoS ONE, 10(11), e0142232.
+ Open protocol
+ Expand
7

Synthesis and Cytotoxicity of Novel Heterocycles

Check if the same lab product or an alternative is used in the 5 most similar protocols
All chemicals were of the highest purity commercially available. Lithium borohydride (LiBH4), 3,5-dichlorophenyl isocyanate and 2,4-thiazolidinedione were obtained from Alfa Aesar (Ward Hill, MA, USA). Ethyl 2-mercaptoacetate, 4-methoxybenzaldehyde, 3,5-dichlorobenzaldehyde, piperidine, pyridine, maleimide, toluene, triethylamine, ethyl acetate, chloroform, hexane, tetrahydrofuran, triphenylphosphine, DMSO, palladium on charcoal and acetone were all obtained from Sigma-Aldrich Co. (St. Louis, MO, USA). Hydrogen Zero Grade was purchased from Airgas (Essington, PA, USA).
The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay kit (“MTS assay”, kit no. G5421) is a product of Promega Corp. (Madison, WI, USA). Human hepatoma HepG2 cells (cat. no. HB-8065) were obtained from American Type Culture Collection (Manassas, VA, USA). Trypsin-EDTA (cat. no. 25-053-CI), penicillin-streptomycin (cat. no. 30-001-CI) and HBSS 1× (cat no. 21-023-CM, with calcium and magnesium, without phenol red) were products of Mediatech, Inc. (Manassas, VA, USA). DMEM 1× (cat. no. 11995-040) was purchased from Life Technologies, Inc. (Carlsbad, CA, USA)
Keil A.M., Frederick D.M., Jacinto E.Y., Kennedy E.L., Zauhar R.J., West N.M., Tchao R, & Harvison P.J. (2015). Cytotoxicity of Thiazolidinedione-, Oxazolidinedione- and Pyrrolidinedione-Ring Containing Compounds in HepG2 Cells. Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1887-1896.
+ Open protocol
+ Expand
8

Spectroscopic Characterization of Substituted Benzaldehydes

Check if the same lab product or an alternative is used in the 5 most similar protocols
2-aminophenol, 2-methoxybenzaldehyde, and 4-methoxybenzaldehyde were purchased from Sigma-Aldrich and used without further purification. The 1H- and 13C-NMR spectra were acquired in CDCl3 at room temperature using a Bruker 400 MHz spectrometer, and their data were recorded in CDCl3, with a residual internal solvent signal of 7.26 and 77.00 ppm, respectively. On a Perkin Elmer FTIR spectrometer equipped with universal ATR, FT-IR spectra reported in wavenumbers (cm−1) were obtained. Mass spectra of the compounds were obtained from a Water synaptic GR electrospray positive spectrometer. The electronic absorption spectra were obtained using a UV-3600 Shimadzu UV–VIS-NIR spectrophotometer. Thermo Scientific FLASH 20 0 0 CHNS/O Analyzers were used for Elemental analyses.
Ibeji C.U., Akintayo D.C., Oluwasola H.O., Akintemi E.O., Onwukwe O.G, & Eziomume O.M. (2023). Synthesis, experimental and computational studies on the anti-corrosion performance of substituted Schiff bases of 2-methoxybenzaldehyde for mild steel in HCl medium. Scientific Reports, 13, 3265.
+ Open protocol
+ Expand
9

Synthesis of Novel Heterocyclic Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols
The starting chemicals were metal salts, ammonium acetate, hydrazine hydrate, acetyl thiophene, 4-methoxy benzaldehyde, ethyl cyanoacetate, ethyl chloroacetate, and potassium carbonate that were purchased from Sigma Aldrich and utilized without additional purification. Fisher Scientific (Loughborough, UK) supplied the solvents, which were ethanol (99%) and N,N-Dimethylformamide (99%).
Saeed S.E., Aldubayyan M., Al-Hakimi A.N, & El-Hady M.M. (2023). Synthesis and Characterization of Pyridine Acetohydrazide Derivative for Antimicrobial Cotton Fabric. Materials, 16(13), 4885.
+ Open protocol
+ Expand
10

Electrochemical Characterization of Benzaldehyde Derivatives

Check if the same lab product or an alternative is used in the 5 most similar protocols
MeCN
(extra high purity,
water content <0.3%, Cryochrom) was used to prepare solutions.
Bu4NClO4 (≥99%, for electrochemical analysis)
was purchased from Sigma-Aldrich and used as a background electrolyte.
Cyclohexanone, cyclopentanone, benzaldehyde, 4-methoxybenzaldehyde,
3,4-dimethoxybenzaldehyde, 4-(methylthio)benzaldehyde, 4-dimethylaminobenzaldehyde,
and 4-diethylaminobenzaldehyde (Sigma-Aldrich) were used as received.
EtOH (chemically pure) was used without additional purification, and
(2E,6E)-2,6-bis(3,4-dimethoxybenzylidene)cyclopentanone
(2) was prepared as described previously.25 (link) DC-Alufolien Aluminiumoxid 60 F254 neutral was purchased from Merck.
Fomina M.V., Vatsadze S.Z., Freidzon A.Y., Kuz’mina L.G., Moiseeva A.A., Starostin R.O., Nuriev V.N, & Gromov S.P. (2022). Structure–Property Relationships of Dibenzylidenecyclohexanones. ACS Omega, 7(12), 10087-10099.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!