Acipimox (Sigma Aldrich, US) was i.p. administered at a dose of 100 mg/kg B.W. two times per day for five consecutive days. Control solution was sterile saline (0.9% NaCl).
Acipimox
Manufactured by Merck Group
Sourced in United States
Acipimox is a synthetic analogue of nicotinic acid (niacin) used as a lipid-lowering agent. It is primarily used to reduce elevated levels of triglycerides and cholesterol in the blood. Acipimox functions by inhibiting the release of free fatty acids from adipose tissue, which in turn reduces the production of very low-density lipoproteins (VLDL) in the liver.
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Lab products found in correlation
2 protocols using acipimox
1
Acipimox administration protocol
2
Lipolysis Inhibitors Modulate Tumor Growth
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To study the role of lipolysis in vivo, mice were given two different lipolysis inhibitors: Acipimox or Atglistatin. Acipimox is a niacin derivate that suppresses cyclic adenosine monophosphate (cAMP), leading to a general inhibition of lipolysis [48 (link)]. Atglistatin is a selective and competitive inhibitor of ATGL, leaving other lipases unaffected [49 (link)]. Mice received either vehicle, Acipimox (0.5 g/L, Sigma-Aldrich, St. Louis, MO, USA) in drinking water or Atglistatin (0.1 μmol/g, Cayman Chemical Company, Ann Arbor, MI, USA) by oral gavage for 14 days after E0771 transplantation. In the Acipimox study, the drinking water was replaced two times per week and the water consumption of each cage was monitored every 24 h.
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