Salicylazosulfapyridine

Sweet tea was collected from Sichuan Mu Jiang Ye Ke Tea Co., Ltd. (Chengdu, China). Dextran sulfate sodium salt (DSS, molecular weight 36–50 kDa); salicylazosulfapyridine (SASP); and standards for SCFAs, including acetic acid, propanoic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, caproic acid, and isohexanoic acid, were purchased from Sigma-Aldrich (St. Louis, MO, USA). The commercial kits for myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α, transforming growth factor-β (TGF-β), IL-10, IL-6, IL-1β, LPS, and urine fecal occult blood were obtained from Nanjing Jiancheng Bioengineering Co., Ltd. (Nanjing, China). The rabbit polyclonal antibodies specific to Zonula occludens-1 (ZO-1), Occludin, G-protein-coupled receptor 43 (GPR43), G-protein-coupled receptor 109A (GPR109A), histone deacetylase 3 (HDAC3), and NF-κB p65 were obtained from Abcam (Shanghai) Trading Co., Ltd. (Shanghai, China).

Lentinan was obtained from Kaifeng Pharmaceutical Co. (Henan, China). The structure of lentinan is shown in Figure S1. Salicylazosulfapyridine (SASP; purity ≥98.0%), TNBS, azoxymethane (AOM) and LPS were purchased from Sigma‐Aldrich Co. (St. Louis, MO, USA). DSS was purchased from MP Biomedicals (Santa Ana, CA, USA, molecular weight; 36 000‐50 000).