The chemotherapeutic agents used included doxorubicin (Fisher Scientific, Waltham, MA, USA), paclitaxel (LKT Laboratories Inc.. St. Paul, MN, USA) and topotecan (Toronto Research Chemicals, Toronto, Canada). The statin drugs used in the research include atorvastatin (Toronto Research Chemicals Inc., Toronto, Canada), fluvastatin (Selleck Chemicals, Houston, TX, USA), lovastatin (EMD Millipore, Billerica, MA, USA), mevastatin (EMD Millipore, Billerica, MA, USA), pravastatin (EMD Millipore, Billerica, MA, USA) and simvastatin (EMD Millipore, Billerica, MA, USA). Mevalonolactone (Sigma-Aldrich, St. Louis, MO, USA) was dissolved in RPMI-1640 medium (Fisher Scientific, Waltham, MA, USA) and titrated with NaOH to a pH of 7.8 to form mevalonate. doxorubicin, fluvastatin and pravastatin were dissolved in distilled water. paclitaxel, topotecan, and atorvastatin were dissolved in methanol. lovastatin, mevastatin and simvastatin were dissolved in dimethyl sulfoxide (DMSO). The chemotherapeutic agents, statins, and mevalonate were aliquoted and stored at − 80 °C.
Atorvastatin
Manufactured by LGC
Sourced in Canada, United Kingdom
Atorvastatin is a pharmaceutical substance used as a laboratory reagent. It functions as an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme involved in the biosynthesis of cholesterol.
Automatically generated - may contain errors
Lab products found in correlation
Mevalonolactone, by Merck Group (1 mentions)
Pravastatin, by Merck Group (1 mentions)
Topotecan, by LGC (1 mentions)
Paclitaxel, by LKT Laboratories (1 mentions)
Rpmi 1640 medium, by Thermo Fisher Scientific (1 mentions)
Doxorubicin, by Thermo Fisher Scientific (1 mentions)
Simvastatin, by Merck Group (1 mentions)
Lovastatin, by Merck Group (1 mentions)
Fluvastatin, by Selleck Chemicals (1 mentions)
Terfenadine, by Merck Group (1 mentions)
Cisapride, by Abcam (1 mentions)
Terodiline, by Merck Group (1 mentions)
Candesartan, by Selleck Chemicals (1 mentions)
Bisoprolol, by Selleck Chemicals (1 mentions)
Bepridil, by Bio-Techne (1 mentions)
Ambrisentan, by Selleck Chemicals (1 mentions)
Amiodarone, by LGC (1 mentions)
Ketotifen, by Tokyo Chemical Industry (1 mentions)
Linagliptin, by Selleck Chemicals (1 mentions)
Astemizole, by Bio-Techne (1 mentions)
2 protocols using atorvastatin
1
Synergistic Chemo-Statin Combination Protocol
2
Drug Compound Sourcing and Preparation
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Ambrisentan, amlodipine, bisoprolol, candesartan, linagliptin, naftopidil, prasugrel, and sumatriptan were purchased from Selleck Chemicals (Houston, TX, USA). Clonidine, glyburide, lisinopril, nicorandil, and propafenone were obtained from Wako (Tokyo, Japan). Efonidipine, mibefradil, terfenadine, and terodiline were provided by Sigma-Aldrich (St. Louis, MO, USA). Aliskiren and warfarin were from LKT Laboratories (St. Paul, MN, USA); astemizole and bepridil were from Tocris Bioscience (Bristol, UK); amiodarone and atorvastatin were from Toronto Research Chemicals (Toronto, Canada); cisapride was from Abcam (Cambridge, UK); and ketotifen was from Tokyo Chemical Industry (Tokyo, Japan). All compounds were dissolved in a mixture of dimethyl sulfoxide (DMSO) and methanol (7:3), and were stored at -80°C. For cell culture, gentamycin and gelatin (type A, cell culture tested) were obtained from Wako and Sigma-Aldrich, respectively.
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