Ly171883

Manufactured by Merck Group

Sourced in United States

Ly171883 is a laboratory instrument manufactured by Merck Group. It is designed for specific research applications. The core function of Ly171883 is to perform analytical tasks required for scientific investigations. Further details on its intended use are not available.

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Lab products found in correlation

3 protocols using ly171883

Calcitriol and Lipid Modulator Evaluation

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Calcitriol and kifunensine were purchased from Tocris Bioscience (Ellisville, MO, USA). Linoleic acid, Ly171883 and Wy14643 were purchased from Sigma-Aldrich (St. Louis, MO, USA).

Lin Y.M., Sun H.Y., Chiu W.T., Su H.C., Chien Y.C., Chong L.W., Chang H.C., Bai C.H., Young K.C, & Tsao C.W. (2018). Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses, 10(2), 57.

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Modulation of Macrophage Activation by NSE

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Male Sprague-Dawley rats (220 ± 20 g) were used in the study. All procedures were conducted in accordance with the rules of Commission on Bioethics of Institute of Biochemistry, National Academy of Science and “General ethics principles on experiments with animals” of the 1st National Congress on Bioethics (Kyiv, 2001). Rat peritoneal macrophages were collected by lavaging peritoneal cavity with RPMI-1640 and cultivated directly on the glass cover-slips in a 35 mm dish (1.6 × 10⁶ cell in each sample) during 60 min with 10 μL lipopolysaccharide (LPS) (from Escherichia coli 0127:B8, Sigma-Aldrich) solution (1 mg/mL PBS). 15 min before LPS stimulation the water suspension of NSE (10⁻⁷M) and/or selective agonist of PPAR-α/γ LY-171883 (Sigma-Aldrich, cat. #L5408) 125 μM, selective antagonist of PPARγ GW9662 (Sigma-Aldrich, cat. #M6191) 1.25 μM were added to the medium.

Kosiakova H., Berdyshev A., Dosenko V., Drevytska T., Herasymenko O, & Hula N. (2022). The involvement of peroxisome proliferator-activated receptor gamma (PPARγ) in anti-inflammatory activity of N-stearoylethanolamine. Heliyon, 8(11), e11336.

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Murine Arachidonic Acid Metabolism

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LTD₄, PGE₂ and murine COX-2 were purchased from Cayman Chemical (Ann Arbor, MI). Non-essential amino acids, FBS, BSA, Fura-2 acetoxymethylester (Fura-2 AM), U73122, dantrolene, Gö 6983, ketoprofen, LY 171883, MK 571, NS 398, SC560 and SC19220, PD98059, ethidium bromide and acridine orange were purchased from Sigma Chemical (St. Louis, MO). LY 255283 was purchased from Tocris Biosc. (Bristol, UK). Arachidonyl trifluoromethylketone (AACOCF₃) and bromoenol lactone (BEL) were acquired from Alexis Corp. (San Diego, CA). [Methyl-³H]thymidine (20 Ci/mmol) and [5,6,8,9,11,12,-14,15-³H] arachidonic acid ([³H]AA) (60-100 Ci/mmol) were from American Radiolabeled Chemicals Inc. (St. Louis, MO), and AH 23838 was kindly provided by Glaxo-Wellcome (Stevenage, UK).

Cabral M., Martín-Venegas R, & Moreno J.J. (2015). Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. Physiological Reports, 3(7), e12417.

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