Gaboxadol hydrochloride (Sigma-Aldrich Co., St. Louis, MO) was dissolved in sterile 0.9% saline. Pregnanolone (5β-pregnan-3α-ol-20-one; National Institute on Drug Abuse Drug Supply Program, Bethesda, MD) was dissolved in 45% (w/v) 2-hydroxypropyl-β-cyclodextrin. Midazolam hydrochloride (Bedford Laboratories, Bedford, OH) and ethanol were purchased as commercially prepared solutions and diluted with sterile 0.9% saline. Flumazenil (Enzo Life Sciences, Farmingdale, NY) was dissolved in a vehicle comprising 10% ethanol, 40% propylene glycol, and 50% sterile water. Drugs were administered i.p. typically in a volume of 1 ml/kg body weight with the exception of ethanol for which a 15% v/v solution was used for all injections. Doses are expressed in the form listed above in mg/kg or g/kg body weight.
Gaboxadol hydrochloride
Manufactured by Merck Group
Gaboxadol hydrochloride is a chemical compound developed by Merck Group for use in pharmaceutical research and development. It functions as a selective agonist of the GABAA receptor, which plays a role in the inhibitory neurotransmission in the central nervous system. The compound is utilized in various in vitro and in vivo laboratory studies to investigate the effects of GABAA receptor modulation.
Automatically generated - may contain errors
Lab products found in correlation
4 protocols using gaboxadol hydrochloride
1
Preparation and Administration of Neuroactive Steroids
2
Cocaine and Gaboxadol Hydrochloride Experiments
3
Gaboxadol-Enriched Paraquat Exposure
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Gaboxadol hydrochloride (Sigma-Aldrich, St. Louis, MO) was dissolved in water and added to melted cornmeal food to a final concentration of 0.1–0.2 mg/mL. Flies were flipped onto Gaboxadol-containing food for 3 days prior to paraquat injection and remained on Gaboxadol-containing food postinjection. Control food was made by adding the appropriate amount of vehicle alone (H2O) to melted cornmeal food.
4
Selective Modulation of GABA Receptor Subtypes
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Drugs were injected i.h. at a volume of 0.25 µL per side at a rate of 0.5 µL min−1 or i.p. at a volume of 200 µL 20–30 min prior to fear conditioning or retrieval test. α4δ- and/or α6δ-subunit-containing GABAAR were activated by gaboxadol hydrochloride (0.5 µg per DH, dissolved in artificial cerebrospinal fluid; Sigma-Aldrich) also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP); α1-3-subunit-containing GABAAR were activated by zolpidem (25 µg per DH, 100% dimethyl sulfoxide (DMSO); Sigma-Aldrich); and α5-subunit-containing GABAAR were activated by SH-053-R-CH3-2'F (20 µg per DH, dissolved in 90% DMSO; synthesized at University of Wisconsin–Milwaukee) or MP-III-022 (12.5 µg per DH; dissolved in 60% DMSO; synthesized at University of Wisconsin–Milwaukee).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!