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Smac mimetic sm 164 54

Manufactured by Selleck Chemicals
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Smac mimetic SM-164 54 is a synthetic compound used as a laboratory research tool. It is designed to mimic the activity of Smac/DIABLO, an endogenous protein that promotes apoptosis, or programmed cell death, by binding to and inhibiting certain members of the inhibitor of apoptosis (IAP) protein family. The core function of this product is to serve as a chemical probe to study the role of IAP proteins in cellular processes.

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Lab products found in correlation

5z 7 oxozeaenol, by Merck Group (2 mentions) Recombinant mouse mtnfα t, by Cell Sciences (2 mentions) Zvad fmk z, by Merck Group (2 mentions) Custom synthesized, by Selleck Chemicals (2 mentions) Cycloheximide (chx), by Merck Group (2 mentions)

Close spelling variants of this product

SM-164

2 protocols using smac mimetic sm 164 54

1

Inducing Apoptosis in Cells via Modulators

Check if the same lab product or an alternative is used in the 5 most similar protocols
Recombinant mouse mTNFα (T) (Cell sciences Cat# CRT192C) was resuspended in PBS at a concentration of 100 μg/ml. zVAD.fmk (Z) (Sigma, Cat# V116) was dissolved in DMSO at a concentration of 20 mM and used at a final concentration of 20 μM. Cycloheximide (Sigma, Cat# C-6255) was resuspended in DMSO at a concentration of 10 mg/ml and used as indicated. 7-Cl-O-Nec-1 (Nec-1s) was made by custom synthesis, dissolved in DMSO at a concentration of 10 mM and used at a final concentration of 10 μM. Custom-synthesized (Selleckchem) Smac mimetic SM-164 54 was resuspended in DMSO at a concentration of 10 mM and used at a final concentration of 500 nM. 5Z-7-Oxozeaenol (Sigma, Cat# 09890) was dissolved in DMSO at a concentration of 25 mM and used at a final concentration of 500 nM.
Dziedzic S.A., Su Z., Barrett V.J., Najafov A., Mookhitiar A.K., Amin P., Pan H., Sun L., Zhu H., Ma A., Abbott D.W, & Yuan J. (2017). ABIN-1 Regulates RIPK1 Activation by Bridging M1 ubiquitination with K63 Deubiquitination in TNF-RSC. Nature cell biology, 20(1), 58-68.
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2

Inducing Apoptosis in Cells via Modulators

Check if the same lab product or an alternative is used in the 5 most similar protocols
Recombinant mouse mTNFα (T) (Cell sciences Cat# CRT192C) was resuspended in PBS at a concentration of 100 μg/ml. zVAD.fmk (Z) (Sigma, Cat# V116) was dissolved in DMSO at a concentration of 20 mM and used at a final concentration of 20 μM. Cycloheximide (Sigma, Cat# C-6255) was resuspended in DMSO at a concentration of 10 mg/ml and used as indicated. 7-Cl-O-Nec-1 (Nec-1s) was made by custom synthesis, dissolved in DMSO at a concentration of 10 mM and used at a final concentration of 10 μM. Custom-synthesized (Selleckchem) Smac mimetic SM-164 54 was resuspended in DMSO at a concentration of 10 mM and used at a final concentration of 500 nM. 5Z-7-Oxozeaenol (Sigma, Cat# 09890) was dissolved in DMSO at a concentration of 25 mM and used at a final concentration of 500 nM.
Dziedzic S.A., Su Z., Barrett V.J., Najafov A., Mookhitiar A.K., Amin P., Pan H., Sun L., Zhu H., Ma A., Abbott D.W, & Yuan J. (2017). ABIN-1 Regulates RIPK1 Activation by Bridging M1 ubiquitination with K63 Deubiquitination in TNF-RSC. Nature cell biology, 20(1), 58-68.
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