Emtricitabine

Manufactured by Bristol-Myers Squibb

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) that is used as a component in the treatment of HIV-1 infection. It functions by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the HIV virus.

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Lab products found in correlation

Efavirenz, by Bristol-Myers Squibb (2 mentions) Atazanavir, by Bristol-Myers Squibb (1 mentions) Atripla, by Bristol-Myers Squibb (1 mentions) Ba 1000, by Vector Laboratories (1 mentions) Ba 9200, by Vector Laboratories (1 mentions)

2 protocols using emtricitabine

Synthesis and Purification of Antivirals

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BMS-378806, BMS-1, BMS-2, BMS-3, BMS-955176, bevirimat (BVM), raltegravir, BMS-817889 (a hepatitis C virus [HCV] NS5B inhibitor), atazanavir (ATV), lamivudine (3TC), abacavir (ABC), emtricitabine (FTC), nelfinavir (NFV), and efavirenz (EFV) were prepared at Bristol-Myers Squibb (BMS). Ritonavir (RTV), nevirapine (NVP), zidovudine (AZT), darunavir (DRV), tenofovir, and rilpivirine (RPV) were purchased and purified from commercial sources.

Nowicka-Sans B., Protack T., Lin Z., Li Z., Zhang S., Sun Y., Samanta H., Terry B., Liu Z., Chen Y., Sin N., Sit S.Y., Swidorski J.J., Chen J., Venables B.L., Healy M., Meanwell N.A., Cockett M., Hanumegowda U., Regueiro-Ren A., Krystal M, & Dicker I.B. (2016). Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage. Antimicrobial Agents and Chemotherapy, 60(7), 3956-3969.

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Antiretroviral Drug Cocktail and Inflammatory Markers

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These were procured from different reliable sources. A combination antiretroviral drug (Atripla) consisting of 600 mg of Efavirenz, 300 mg Tenofovir disproxil Fumurate, and 245 mg Emtricitabine was procured from Bristol-Myers Squibb and Gilead Sciences. Rabbit polyclonal for primary antibodies interleukin-1beta (IL-1β) (ab2105), tumor necrosis factor-alpha (TNF-α) (ab6671), and caspase 3 (ab4051), rabbit monoclonal for primary antibody inducible nitric oxide synthase (iNOS) (ab115819), and mouse monoclonal for primary antibodies interleukin-6 (IL-6) (ab9324), malondialdehyde (MDA) (ab243066), and 8-hydroxydeoxyguanosine (8-OHDG) (ab62623) were procured from Abcam . Whilst biotinylated goat anti-rabbit (BA-1000) and goat anti-mouse (BA-9200) secondary antibodies, and Avidin-Biotin Complex kit (ABC) (PK-6100) were procured from Vector Laboratories.

Owembabazi E., Nkomozepi P., Calvey T, & Mbajiorgu E.F. (2023). Co-administration of alcohol and combination antiretroviral therapy (cART) in male Sprague Dawley rats: a study on testicular morphology, oxidative and cytokines perturbations. Anatomy & Cell Biology, 56(2), 236-251.

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