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Piperazine

Manufactured by Merck Group
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Piperazine is a heterocyclic organic compound with the chemical formula C4H10N2. It is a colorless crystalline solid with a melting point of 108-113°C. Piperazine is used as a building block in the synthesis of various pharmaceutical and chemical products.

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Lab products found in correlation

Hydrochloric acid (hcl), by Merck Group (6 mentions) Methanol, by Merck Group (5 mentions) N hexane, by Merck Group (5 mentions) Sodium chloride (nacl), by Merck Group (5 mentions) Piperidine, by Merck Group (4 mentions) Sodium hydroxide (naoh), by Merck Group (4 mentions) Trimesoyl chloride, by Merck Group (4 mentions) 1 6 hexanediol diacrylate, by Merck Group (4 mentions) Sodium alginate, by Merck Group (4 mentions) Triethylamine, by Merck Group (4 mentions) Dimethyl sulfoxide (dmso), by Merck Group (4 mentions) Methanol, by Thermo Fisher Scientific (3 mentions) Morpholine, by Merck Group (3 mentions) Ethanol, by Merck Group (3 mentions) Gentamicin sulphate, by Merck Group (3 mentions) Chlorhexidine diacetate, by Merck Group (3 mentions) Triton x 100, by Merck Group (3 mentions) Sodium acetate trihydrate, by Merck Group (3 mentions) Glacial acetic acid, by Thermo Fisher Scientific (3 mentions) Phosphate buffer solution (pbs), by Merck Group (3 mentions)

Close spelling variants of this product

HEPES (N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)) 1-(2-aminoethyl)piperazine 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid sodium salt (HEPES) 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt 1,4-bis(2-hydroxyethyl)piperazine Hydroxyethyl piperazine ethane sulfonic acid (HEPES), 1-(2-Pyridyl) piperazine N-(2-hydroxyethyl)piperazine-N′-ethanesulfonicacid N-(2-Hydroxyethyl)piperazine-N′-ethanesulfonic acid (HEPES), Dimethyl-γ-butyrolactone acrylate (DBA), glycidyl methacrylate (GMA), acrylic acid (AA), 2,2’-azobis(2-methylpropionitrile) (azobisisobutyronitrile, AIBN), N,N’-methylenebisacrylamide (MBA), piperazine (PiP), glycine

58 protocols using piperazine

1

Flame Retardant Polymer Synthesis

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Aniline, piperazine, resorcinol,
diphenyl chlorophosphate, dimethyl methyl phosphonate, methanol, and
1,3-phenylene diamine were purchased from Aldrich, Germany. Thionyl
chloride, triethylamine, chloroform, and tetrahydrofuran (THF) were
purchased from Samchun Chemical Company, Korea. Polycarbonate (PC),
ABS, and RDP of commercial grades were provided by Cheil Industries,
Korea. EVA which is a blend of EVA copolymer, LLDPE, and PE-g-MA (80:10:10) was provided by the LS-Cable Company, Korea.
Vothi H., Nguyen C., Pham L.H., Hoang D, & Kim J. (2019). Novel Nitrogen–Phosphorus Flame Retardant Based on Phosphonamidate: Thermal Stability and Flame Retardancy. ACS Omega, 4(18), 17791-17797.
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2

Synthesis of Isocyanate-Based Heterocyclic Compounds

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1-chloro-2-isocyanatoethane, thiomopholine, morpholine and piperazine were supplied by Sigma-Aldrich. Laboratory regent grade diethyl ether (EMD Chemicals) was used as the reaction solvent without further purification. ClCH2CH2NHC(O)N(CH2CH2)2S [29 ] (CTC), ClCH2CH2NHC(O)N(CH2CH2)2NC(O)NHCH2CH2Cl [30 ] (CPC) and ClCH2CH2NHC(O)N (CH2CH2)2O [31 ], (CMC) were synthesized according to literature procedures.
Nwuche C.O., Ujam O.T., Ibezim A, & Ujam I.B. (2017). Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine. PLoS ONE, 12(1), e0170150.
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3

Synthesis of Piperazine-Containing Compounds

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Phosphoryl trichloride, vinyl magnesium bromide (1M in THF), dry THF, 1,6-dibromohexane, 1,10-dibromodecane, 1,3-di(piperidin-4-yl)propane, piperazine, piperidine, tert-butyl piperazine-1-carboxylate (1), cyanuric chloride (6), Acid blue 90, Acid blue 80 and Fluorescein were obtained from Aldrich and used as received unless otherwise stated. The compounds trivinylphosphine oxide (TVPO), 46 1,6-di(piperazin-1-yl)hexane (3), 47 1,10-di(piperazin-1-yl)decane (5) 47 were synthesized via modified procedures (SI section S2) and 2,4,6-tri(piperazin-1-yl)-1,3,5-triazine (8) 48 was synthesized using procedure as described in the literature.
Nazir R., Parida D., Guex A.G., Rentsch D., Zarei A., Gooneie A., Salmeia K.A., Yar K.M., Alihosseini F., Alihosseini F., Sadeghpour A, & Gaan S. (2020). Structurally Tunable pH-responsive Phosphine Oxide Based Gels by Facile Synthesis Strategy. ACS applied materials & interfaces, 12(6).
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4

Solid-Phase Peptide Synthesis Protocol

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Trifluoroacetic acid (TFA), Triisopropylsilane (TIS), Fmoc amino acids and coupling reagent O-(7-Azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HATU) and benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBop) were supplied by the Merck Co, Germany. Solvents, acetonitrile (MeCN), Piperazine, N, N-diisopropylethylamine (DIPEA), diethylether, Dichloromethane (DCM), N, N-dimethylformamide (DMF), and methanol (MeOH) were purchased from the Merck Co, Germany. 2-Chlorotritylchloride(2-CTC) resin (1% DVB, 200-400 mesh, 1 mmol/g) was from the Santa Cruz Biotechnology Co, USA. Commercially available chemicals were used as received unless otherwise stated. Fourier Transform Infrared spectra were obtained by the Shimadzu recording spectrometer, Japan. The mass spectral measurements were performed using a 6410 Agilent LCMS triple quadrupole mass spectrometer (LCMS) with an electrospray ionization (ESI) interface, USA. The cell lines were purchased from Iranian Biological Resource Center (IBRC), Tehran, Iran.
Tehrani M.H., Bamoniri A, & Gholibeikian M. (2018). The toxicity study of synthesized inverse carnosine peptide analogues on HepG2 and HT-29 cells. Iranian Journal of Basic Medical Sciences, 21(1), 39-46.
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5

Synthesis of Anion Exchange Resins

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The anion exchange-resin Lewatit Monoplus MP 800 was provided by Lanxess (Leverkusen, Germany). Double-distilled water, potassium hydroxide, chloroform (≥99%), acetone (≥99%), dichloromethane (≥99%), potassium persulfate, sodium metabisulphite, sodium hydroxide (97%) and N,N’-methylenebisacrylamide were obtained from VWR International GmbH (Darmstadt, Germany). Potassium carbonate (99%), allyl bromide (99%), methanol (99%) and 1,3-bis(4-piperidyl)propane (97+%) were obtained from Alfa Aesar (Kandel, Germany), diallyldimethylammonium chloride (65 wt% in H2O) and triallylamine (99%) were obtained from Sigma Aldrich. Piperazine, diallylamine (97%) and D2O (99.9%) were purchased from Merck KGaA (Darmstadt, Germany). The polyester filter bags with a maximum mesh size of 90 µm were bought from Rosin Tech Products (Bethpage, NY, USA).
Mrohs T.B, & Weichold O. (2022). Multivalent Allylammonium-Based Cross-Linkers for the Synthesis of Homogeneous, Highly Swelling Diallyldimethylammonium Chloride Hydrogels. Gels, 8(2), 100.
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6

Fluorescent Probe for Biomolecular Detection

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Acenaphthene, piperazine, bromomethylphenyl boronic acid pinacol ester and ortho-phenylenediamine were purchased from Merck Chemical Co. The graphene oxide nanoplatelets were purchased from Nano SANY Co. with a commercial code of US 7906, CAS 7732-18-5. The following experiments were conducted in PBS/DMF (99 : 1). This research was performed in accordance with the Declaration of Helsinki and with approval of the ethics board of the University of Tehran. Human plasma sample used in this work was from a healthy volunteer with O-positive blood who signed an informed consent form in the Iranian Blood Transfusion Center. It was a fresh frozen plasma (product code: E070V00). Fluorescence quantum yield was evaluated based on the absorption and fluorescence spectra, using fluorescein as a reference (φst = 0.95).34 (link) The melting points (m.p.) were measured using a PerkinElmer (USA) Pyris 6 differential scanning calorimeter. Synthesis procedure for the fluorescent probe (NOPB) is illustrated in Scheme 1 (synthesis procedure and characterization of compounds are given in ESI S1 and S2†).
Seraj S., Rouhani S, & Faridbod F. (2019). Naphthalimide-based optical turn-on sensor for monosaccharide recognition using boronic acid receptor. RSC Advances, 9(31), 17933-17940.
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7

Synthesis and Characterization of Cyclodextrin Derivatives

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6-Mono-O-tosyl-β-CD was the product of CycloLab Ltd. (Budapest, Hungary). Reagents as N,N-dimethylformamide (DMF), acetone, 2-propanol, NH3 were of reagent grade and sourced from Molar Chemicals Ltd. (Halásztelek, Hungary), piperidine, piperazine, pyrrolidine, morpholine, iodomethane (CH3I), collidine were of reagent grade and purchased from Merck KGaA (Darmstadt, Germany), potassium hydroxide, hydrochloric acid, sodium hydroxide, phosphoric acid, acetic acid, Tris, sodium dihydrogen phosphate and sodium tetraborate were of reagent grade and sourced from Sigma-Aldrich (St. Louis, MO, USA). D2O (99.9% D atom) and silica gel (0.0063–0.200 mm for column chromatography) were purchased from Merck KGaA (Darmstadt, Germany). The chiral test analytes used in the CE measurements were obtained from Sigma-Aldrich except for mandelic acid, which was obtained from Merck KGaA.
Fejős I., Kalydi E., Kukk E.L., Seggio M., Malanga M, & Béni S. (2021). Single Isomer N-Heterocyclic Cyclodextrin Derivatives as Chiral Selectors in Capillary Electrophoresis. Molecules, 26(17), 5271.
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8

Fabrication of PES Membranes for Water Treatment

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Polyether sulfone (PES) membrane (UP150, 150 kDa) was purchased from Microdyn Nadir GmbH (Wiesbaden, Germany). N-N-Dimethylacetamide (DMAc, 99%), n-hexane (96%), and piperazine (PIP, Mw = 86.14 g/mol) were purchased from Merck (Darmstadt, Germany). 1,3,5-benzene tricarboxylic chloride (TMC, 98%) and zinc chloride (ZnCl2, 99%) were obtained from Sigma-Aldrich (Darmstadt, Germany). Sodium chloride (NaCl, ≥99%), sodium sulfate (Na2SO4, ≥99%), sodium hydroxide pellets (NaOH, 99%), and Congo red (CR, Mw = 696.65 Da) were supplied from AFG Bioscience (Northbrook, IL, USA). Reactive Red 198 (RR, Mw = 984.21 g/mol) was purchased from Dystar (Raunheim, Germany). Iron(III) chloride hexahydrate (FeCl36H2O) and cerium(III) nitrate hexahydrate (Ce(NO3)3.6H2O) were obtained from Sigma-Aldrich (Darmstadt, Germany).
Balcik C., Ozbey-Unal B., Sahin B., Keyikoğlu R, & Khataee A. (2023). Loose Nanofiltration Membrane Incorporating CeZnFe Layered Double Hydroxide with Enhanced Dye/Salt Separation Performance and Self-Cleaning Ability. Membranes, 13(8), 711.
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9

Metal-Organic Framework Synthesis

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All reagents were used as received and without further purification. Ferrous chloride tetrahydrate (FeCl2·4H2O), manganese(ii) acetate tetrahydrate (Mn(OAc)2·4H2O), potassium dichromate (K2Cr2O7), piperazine, formaldehyde, H2SO4, ammonium oxalate ((NH4)2C2O4), ethanol, methanol, citric acid, formic acid, KOH and Na2EDTA were purchased from Merck. Distilled water was used for the preparation of the solutions.
Garazhian Z., Farrokhi A., Rezaeifard A., Jafarpour M, & Khani R. (2021). The enhanced visible-light-induced photocatalytic activities of bimetallic Mn–Fe MOFs for the highly efficient reductive removal of Cr(vi). RSC Advances, 11(34), 21127-21136.
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10

Organic Photovoltaic Device Fabrication

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Piperazine, NAP, BAP, regioregular P3HT (Mn 30 000–60 000), Triton-X
100, and 1,2-dichlorobenzene (DCB) were purchased from Sigma-Aldrich.
2-Propanol (IPA) and ethanol were purchased from Kanto Chemical Co.
PEDOT:PSS dispersion in water (Clevios P) (1.3 wt %) was purchased
from H.C. Starck. PCBM was purchased from Frontier Carbon. ITO substrates
(sheet resistance = 10 Ω sq–1) and Au wires
were purchased from Furuuchi Chemical Corporation. Quartz substrates
were purchased from Iiyama Precision Glass Co., Ltd. ITO layers (10
Ω sq–1) on the quartz substrates were fabricated
by Geomatec Co., Ltd. Masking tape E-MASK TP200 was provided from
Nitto Denko. Lamination film Cellel F1550H was purchased from Kureha
Extech.
Kusumi T., Kuwabara T., Fujimori K., Minami T., Yamaguchi T., Taima T., Takahashi K., Murakami T., Rachmat V.A, & Marumoto K. (2017). Mechanism of Light-Soaking Effect in Inverted Polymer Solar Cells with Open-Circuit Voltage Increase. ACS Omega, 2(4), 1617-1624.
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