Sound attenuating cubicle

Manufactured by Med Associates

Sourced in Sao Tome and Principe, United States

Sound-attenuating cubicles are designed to reduce ambient noise levels in controlled environments. They are constructed with materials that absorb and block sound transmission, creating a more isolated and quiet workspace.

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Lab products found in correlation

41 protocols using sound attenuating cubicle

Operant Conditioning in Mice: Tone and Click Stimuli

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The apparatus consisted in eight standard mouse operant chambers housed inside sound-attenuating cubicles (Med Associates, St. Albans, VT, USA) equipped with a house light, a fan, two nosepokes on the front wall and one nosepoke on the back wall, a programmable audio generator, a shocker/scrambler module, a lever, and a standard mouse 20-mg pellet feeder. The pre-exposed (PE) and non-pre-exposed (NPE) conditioned stimuli were a 80-dB tone and a 10-Hz click. The US was a 1-s 0.5 mA footshock.

Buhusi M., Brown C.K, & Buhusi C.V. (2017). Impaired Latent Inhibition in GDNF-Deficient Mice Exposed to Chronic Stress. Frontiers in Behavioral Neuroscience, 11, 177.

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Pavlovian Conditioning in Operant Chambers

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Pavlovian conditioning experiments were conducted in Med-Associates operant chambers (21.6×17.8× 12.7 cm; Med Associates, St. Albans, VT) contained within sound attenuating cubicles (Med Associates, St. Albans, VT). Operant chambers were equipped with rod floors, two plexi-glass side walls, front and back metal walls, and a liquid dipper arm that delivered approximately 10 μl of vanilla-flavored Ensure (diluted in water to a 1:1 ratio) from a reservoir. On the back wall, there was a speaker (65db, 2900 Hz). A house light was placed outside of the left Plexiglas side wall, providing light to the chamber. In the middle of the front wall was a food hole flanked on either side by lever slits, above which cue lights were mounted. For all experiments described here, the CS was a tone and cue light. The CS was always 5 seconds in duration except for experiment 4, when it was 0.5 seconds. The US was the Ensure solution presented for 15 seconds. The food hole was fitted with infrared photobeam sensors that counted the number and time of head entries into the food hole. 24 hours before experiments began, mice were given the Ensure solution for reward habituation and to prevent neophobia during the experiment.

Ghobbeh A., Taugher R.J., Alam S.M., Fan R., LaLumiere R.T, & Wemmie J.A. (2018). A novel role for acid-sensing ion channels (ASIC1A) in Pavlovian reward conditioning. Genes, brain, and behavior, 18(7), e12531.

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Operant Alcohol Self-Administration Paradigm

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Operant alcohol self-administration, extinction, and reinstatement sessions were conducted in operant conditioning chambers housed in sound-attenuating cubicles (Med Associates, St. Albans, VT). Operant conditioning chambers were equipped with two retractable levers situated on either side of a magazine into which a dipper arm would deliver 0.05ml of the ethanol solution. Delivery of the reinforcer was accompanied by illumination of a cue light above the active lever and sounding of a 75 dB tone. During testing, the house light was illuminated and an exhaust fan was turned on to mask external noise. All operant sessions (except where noted) were 1 hour in length.

Bertholomey M.L, & Torregrossa M.M. (2017). Gonadal hormones affect alcohol drinking, but not cue+yohimbine- induced alcohol seeking, in male and female rats. Physiology & behavior, 203, 70-80.

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Operant Cocaine Self-Administration Protocol

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Self-administration was conducted in operant chambers housed within sound-attenuating cubicles (MedAssociates, St. Albans, VT). Chambers were equipped with house lights, cue lights, and two retractable levers (one active; one inactive). Active lever pressing initiated the activation of the syringe pump (MedAssociates) to deliver a drug infusion (rate 60 µl in 5 s, 15 s post-infusion timeout). Drug delivery and data collection were controlled by MedAssociates software (MedPCIV). Following catheterization surgery, animals were recovered for 1 week prior to initiation of self-administration.

Vassoler F.M., Oliver D.J., Wyse C., Blau A., Shtutman M., Turner J.R, & Byrnes E.M. (2016). Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure. Neuropharmacology, 113(Pt A), 271-280.

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Conditioned Fear Extinction Paradigm in Rats

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Rats were fear conditioned in standard experimental chambers (27 cm long, 28 cm wide, 28 cm tall; Coulbourn Instruments, Allentown, PA) located inside sound-attenuating cubicles (Med Associates, Burlington, VT), similar to our previous studies (Sierra-Mercado et al. 2011 (link)). The floor of the chambers consisted of stainless steel bars that delivered a scrambled electric footshock. The same chamber was used for conditioning, extinction training, and retrieval tests. Rats were conditioned with a pure tone (30 s, 4 kHz, 75 dB) that co-terminated with shock delivery to the floor grids (0.5 s, 0.20 or 0.50 mA). All trials were separated by a variable interval averaging 3 min. Throughout all phases of training, rats pressed a lever for a sucrose pellet on a VI-60 schedule.
Fear conditioning consisted of one habituation tone (no shock), followed by six tone-shock pairings. One day later, 20 tones (3 min ITI) without shock were presented to extinguish the conditioning association. Twenty-four hours after extinction training, we tested the extinction memory with an eight-tone test. A separate group of rats was conditioned using a sub-threshold conditioning shock (0.2 mA) and was tested with a two-tone test, instead of an eight-tone test, to avoid extinguishing freezing.

Quiñones-Laracuente K., Hernández-Rodríguez M.Y., Bravo-Rivera C., Melendez R.I, & Quirk G.J. (2015). The effect of repeated exposure to ethanol on pre-existing fear memories in rats. Psychopharmacology, 232(19), 3615-3622.

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Operant Conditioning Chamber for Drug Self-Administration

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All self-administration sessions were conducted inoperant conditioning chambers (30.5cm × 24cm × 21cm) placed inside sound attenuating cubicles (Med Associates Inc., St. Albans, VT). Each chamber is equipped with two nose-poke devices (ENV-114BM; Med Associates Inc.) positioned 3cm above the stainless steel grid floor and a white house light on the opposite wall. A variable rate infusion pump (PHT-107; Med Associates Inc.) delivered drug or vehicle infusions through Tygon tubing and a spring tether connected to a fluid swivel (Instech Laboratories Inc., Plymouth Meeting, PA) on a counter-balanced arm (PHM-110-SAI; Med Associates Inc.).

Eagle A.L., Singh R., Kohler R.J., Friedman A.L., Liebowitz C.P., Galloway M.P., Enman N.M., Jutkiewicz E.M, & Perrine S.A. (2015). Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. Behavioural brain research, 284, 218-224.

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Intravenous Cocaine and Sensory Self-Administration in Mice

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Intravenous cocaine and sensory self-administration data were collected using 32 modular mouse operant conditioning chambers enclosed in sound attenuating cubicles (Med Associates; St. Albans, Vermont). The floor of each chamber consisted of bars which were covered by a single piece of white PVC to facilitate cleaning and mouse ambulation. Two retractable response levers were mounted to the left and right sides of the front wall (henceforth inactive lever and cocaine lever, respectively). A third retractable response lever (henceforth sensory lever) was mounted on the back wall directly across from the inactive lever. A stimulus light was mounted directly above each of the three levers. A house light was centrally mounted on the front wall of each chamber. A 25-gauge single-channel plastic swivel was mounted to a counterbalanced lever-arm attached to the lid of the chamber. An infusion pump was mounted within the sound attenuating cubicle outside of the operant conditioning chamber. Tubing was used to connect a 20 mL syringe mounted in the infusion pump to the swivel. During cocaine self-administration testing, tubing was used to connect the externalized catheter port on the midscapular region of the mouse to the plastic swivel. Operant conditioning chambers were controlled by two Med Associates control units using MED-PC V software.

Leonardo M., Brunty S., Huffman J., Lester D.B, & Dickson P.E. (2023). Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference. Scientific Reports, 13, 2810.

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Voltammetric Recordings during Delay Discounting

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Voltammetric recordings during delay discounting were completed in custom-built operant chambers (43 × 43 × 53 cm) housed in a copper mesh Faraday cage sound-attenuated cubicle. Each chamber contained a houselight, white noise generator, two retractable levers with two cue lights above them, and a food receptacle equal distance between the levers. Self-administration sessions were conducted in separate, contextually distinct, operant chambers (25 × 25 × 30 cm) housed in sound-attenuating cubicles (Med Associates). One wall of these chambers contained a nosepoke device, a houselight, and a tone generator. The opposite wall contained two retractable levers with cue lights above them, and a water receptacle positioned between the levers. Cocaine/saline infusion was delivered via tubing running through a counterweighted arm and controlled by a motorized syringe pump. For both sets of chambers, behavioral events were recorded and controlled by a computer running Med-PC software (Med Associates).

Moschak T.M, & Carelli R.M. (2017). Impulsive Rats Exhibit Blunted Dopamine Release Dynamics during a Delay Discounting Task Independent of Cocaine History. eNeuro, 4(2), ENEURO.0119-17.2017.

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Contextual Fear Conditioning in Mice

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Four–five weeks after surgery, mice received 2 d of handling, 10–15 min on the first day and ∼5 min on the second day. After handling, mice were trained with a contextual fear conditioning procedure in four identical footshock chambers (32 × 25 × 25 cm) illuminated by lights inside sound-attenuating cubicles (64 × 75 × 36 cm; Med Associates, Inc.), silencing the dHPC projection either during acquisition or retrieval/expression of recent and remote contextual memory. To minimize laser leaking from the optical fiber attachment, a tight sleeve (black shrinking tube) covered this attachment. To reduce the mouse's time spent in the footshock chamber before recording began, two chambers were used when one experimenter was present, or four chambers were used when two experimenters were present. All behavioral procedures began around 4:00 P.M. During acquisition and retrieval tests, mice were counterbalanced among pairs and tested in separate chambers. After each mouse was tested, the chamber was cleaned with 70% ethanol.

Opalka A.N, & Wang D.V. (2020). Hippocampal efferents to retrosplenial cortex and lateral septum are required for memory acquisition. Learning & Memory, 27(8), 310-318.

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Stress-Induced Ethanol Reinstatement in msP Rats

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Male msP rats (n = 30) were individually-housed with food and water available ad libitum except during the training and test sessions. Experiments were conducted in standard rat operant chambers housed within sound-attenuating cubicles (Med-Associates, St. Albans, VT), as previously described (Ciccocioppo et al., 2004 (link)). During daily 30-min operant sessions, rats were trained to self-administer a 10% (v/v) ethanol solution under a fixed-ratio-1 schedule of reinforcement, in which each response resulted in the delivery of 0.1 mL ethanol, followed by a 5-sec time out period, signaled by illumination of a 5W house light. Once stable baseline responding was achieved, rats were subjected to 30-min extinction sessions. During extinction sessions, all procedures were the same, except lever responses were no longer reinforced. After lever responses were extinguished, msP rats were subjected to a stress-induced reinstatement test conducted under the same extinction conditions, except that rats received the pharmacological stressor, yohimbine (2 mg/kg IP), 30 min before the session. Once stable baseline extinction responding was recovered following the previous yohimbine challenge, rats were randomly divided into 3 groups (N=10/group) and pretreated with LY2940094 (0, 3 or 10 mg/kg, PO) 60 min before the reinstatement test (30 min before yohimbine).

Rorick-Kehn L.M., Ciccocioppo R., Wong C.J., Witkin J.M., Martínez-Grau M.A., Stopponi S., Adams B.L., Katner J.S., Perry K.W., Toledo M.A., Diaz N., Lafuente C., Jiménez A., Benito A., Pedregal C., Weiss F, & Statnick M.A. (2016). A novel, orally-bioavailable nociceptin receptor antagonist, LY2940094, reduces ethanol self-administration and ethanol-seeking in animal models. Alcoholism, clinical and experimental research, 40(5), 945-954.

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