Dynascope confocal microscope

Manufactured by Zeiss

The Dynascope is a confocal microscope designed by Zeiss. It utilizes laser scanning technology to provide high-resolution, three-dimensional imaging of samples. The core function of the Dynascope is to generate detailed, optical cross-sections of specimens through the use of a focused laser beam and a pinhole aperture.

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Lab products found in correlation

Zen software, by Zeiss (2 mentions) Plan apochromat, by Zeiss (1 mentions) Plan apochromat 20x 0.75 objective, by Zeiss (1 mentions)

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Confocal microscope

2 protocols using dynascope confocal microscope

Confocal Imaging of Mitotic Cells

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Ex vivo experiments were conducted on cells grown on Lab-Tek chambered coverglass (Nalgen Nunc International) and maintained under standard culture conditions (37°C, 5% CO₂). Images were acquired on a Zeiss dynascope confocal microscope using a PlanApochromat 40× water immersion objective. Images were analysed with the Zen software provided by Zeiss. C5M was added just before imaging.
At least 10 mitotic cells were simultaneously followed and three independent experiments were conducted.

Le L.T., Couvet M., Favier B., Coll J.L., Nguyen C.H, & Molla A. (2015). Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle. Oncotarget, 6(26), 22152-22166.

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Imaging Mitotic Dynamics in Spheroids

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Ex vivo experiments were conducted on cells grown on Lab-Tek chambered coverglass (Nalgen Nunc International) and maintained under standard culture conditions (37°C, 5% CO₂). Spheroids were recovered by pipetting just before imaging and deposited in the Lab-Tek well containing cell culture medium. Images were acquired on a Zeiss dynascope confocal microscope using a Plan-Apochromat 20X / 0.75 objective. Images were analysed with the Zen software provided by Zeiss and a median filter (3/3/1) was applied to all images. At least 10 mitotic cells were simultaneously followed and three independent experiments were conducted.

Molla A., Couvet M, & Coll J.L. (2017). Unsuccessful mitosis in multicellular tumour spheroids. Oncotarget, 8(17), 28769-28784.

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