erastin (Bio-techne, 5449); SAS (MedchemExpress, HY-14655); RSL3 (Cayman, 19288); FIN56 (Cayman, 25180); FINO2 (MedchemExpress, HY-129457); PANKi (Cayman, 31002); BSO (Sigma, B2515); DEM (Sigma, D97703); etomoxir sodium salt (Selleckchem, S8244); lovastatin (Selleckchem, S2061); TOFA (Selleckchem, S6690); dorsomorphin (Selleckchem, S7306); alisertib (Selleckchem, S1133); verdinexor (Cayman, 26171); leptomycin B (Cayman, 10004976); tipifarnib (MedchemExpress, HY-10502); methotrexate (Selleckchem, S1210); pitstop2 (Sigma, SML1169); EML425 (Selleckchem, S2977); C646 (Selleckchem, S7152); brequinar (Selleckchem, S3565); elamipretide (Selleckchem, S9803)
Tipifarnib
Manufactured by MedChemExpress
Sourced in United States
Tipifarnib is a farnesyltransferase inhibitor that blocks the post-translational modification of Ras proteins, which are involved in cell signaling pathways. It is a white to off-white crystalline powder.
Automatically generated - may contain errors
Lab products found in correlation
Pitstop 2, by Merck Group (1 mentions)
Leptomycin b, by Cayman Chemical (1 mentions)
Erastin, by Bio-Techne (1 mentions)
Lovastatin, by Selleck Chemicals (1 mentions)
Verdinexor, by Cayman Chemical (1 mentions)
Methotrexate, by Selleck Chemicals (1 mentions)
Brequinar, by Selleck Chemicals (1 mentions)
Alisertib, by Selleck Chemicals (1 mentions)
Fin56, by Cayman Chemical (1 mentions)
Dorsomorphin, by Selleck Chemicals (1 mentions)
Adagrasib, by MedChemExpress (1 mentions)
Lonafarnib, by Merck Group (1 mentions)
Sw1573, by American Type Culture Collection (1 mentions)
Tipifarnib, by Merck Group (1 mentions)
Sotorasib, by MedChemExpress (1 mentions)
2 protocols using tipifarnib
1
Ferroptosis Inducers and Inhibitors Screening
2
Evaluating KRAS-G12C Inhibitors in Cancer
Check if the same lab product or an alternative is used in the 5 most similar protocols
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Three KRAS-G12C mutant lung adenocarcinoma, one colorectal and one pancreatic cancer cell line were involved in this study shown in Supplementary Table 1 . H358 and SW1573 were purchased from ATCC. PF97 and PF139 cells were established from malignant pleural effusion samples in cooperation with the West German Biobank Essen as described earlier [16 (link)]. The patients provided written informed consent and the experiments were approved by the Ethics Committee of the University Hospital Essen (#18-8208-BO).
Lonafarnib and tipifarnib (for in vitro experiments) were purchased from Sigma (St. Louis, MO, USA), while sotorasib, adagrasib and tipifarnib (for in vivo experiments) were obtained from Medchemexpress. For in vitro experiments, drugs were dissolved in dimethyl sulfoxide (DMSO) in 10 mM stock concentration and stored at −80 °C.
Lonafarnib and tipifarnib (for in vitro experiments) were purchased from Sigma (St. Louis, MO, USA), while sotorasib, adagrasib and tipifarnib (for in vivo experiments) were obtained from Medchemexpress. For in vitro experiments, drugs were dissolved in dimethyl sulfoxide (DMSO) in 10 mM stock concentration and stored at −80 °C.
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