Gossypol

Manufactured by Selleck Chemicals

Sourced in Germany

Gossypol is a natural polyphenolic compound extracted from the cotton plant. It functions as a chemical reagent with applications in various laboratory settings.

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Gossypol acetate (2 citations)

3 protocols using gossypol

Investigating Multitargeted Anticancer Potentials

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Sunitinib, veliparib, olaparib, mefloquine, simvastatin, dihydroartemisinin, tanshinone I, cryptotanshinone, gossypol and docetaxel were purchased from Selleck Chemicals. Anti-FoxO3a (cat. no. 12829), anti-α/β-tubulin (cat. no. 2148) and anti-Bcl-2 (cat. no. 15071) antibodies were purchased from Cell Signaling Technology, Inc. phosphorylated (p)FoxO3a were from Abcam Inc. (cat. no. ab154786). Anti-PARP1 (cat. no. sc-8007) was obtained from Santa Cruz Biotechnology, Inc. tanshinone I, dioscin and simvastatin were obtained from Shanghai YuanYe Biotechnology Co., Ltd. D MEM, RPMI-1640, MEM and FBS were obtained from Gibco; Thermo Fisher Scientific, Inc. MTS was purchased from Shanghai BestBio (cat. no. BB-4204-3). The secondary fluorescent antibodies, IRDye 800CW goat anti-mouse (cat. no. 926-32210) and IRDye 800CW goat anti-rabbit (cat. no. 926-32211) were from were from LI-COR. All other laboratory reagents in common use were of domestic analytical pure grade.

Zhang Y., Huang J., Huang Y., Zhang S., Wu W., Long H., Duan X., Lai Y, & Wu W. (2020). Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression. Molecular Medicine Reports, 23(1), 40.

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Pharmacological Modulation of H9c2 Cells

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H9c2 cells (ATCC; CRL-1446) were cultured in DMEM supplemented with 10% fetal bovine serum (FBS). At 90% confluence, H9c2 cells were treated with emodin (2 hrs; SelleckChem; S2295), gossypol (2 hrs; SelleckChem; S2303), luteolin (2 hrs; SelleckChem; S2320), quercetin dihydrate (2 hrs; SelleckChem; S2347), TSA (2 hrs; Sigma T8552), or DMSO.

Godoy L.D., Lucas J.E., Bender A.J., Romanick S.S, & Ferguson B.S. (2017). Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity. Molecular nutrition & food research, 61(4), 10.1002/mnfr.201600744.

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Preparation of BH3 Mimetic Compounds

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The BH3 mimetic compounds ABT-263, ABT-199, ABT-737, AZD5991, Gambogic acid, Gossypol, Obatoclax, Sabutoclax, S55746, and TW-37 (Selleckchem, Cologne, Germany) were dissolved in DMSO to obtain 10 mM stock solutions.

Castillo Bautista C.M., Eismann K., Gentzel M., Pelucchi S., Mertens J., Walters H.E., Yun M.H, & Sterneckert J. (2023). Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy. Cells, 12(18), 2247.

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