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Running wheel

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The Lafayette Instrument Running Wheels are designed for use in animal research. The product provides a controlled environment for small animals to engage in voluntary physical activity. The running wheels are constructed with durable materials and feature an adjustable design to accommodate a range of animal sizes.

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Lab products found in correlation

Activity wheel monitor software, by Lafayette Instrument (2 mentions) Awm software, by Lafayette Instrument (1 mentions) D12492, by Research Diets (1 mentions) C57bl 6j mice, by Jackson ImmunoResearch (1 mentions) Labview programming software, by National Instruments (1 mentions) Clocklab software, by Actimetrics (1 mentions)

19 protocols using running wheel

1

Exercise-induced Brain Mapping

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Two weeks after the lesioning, animals assigned to the exercise group were trained in a running wheel (36 rungs of 14.6 mm diameter, 4.4° angular spacing, Lafayette Instrument, Lafayette, IN, USA) for 20 min/day (4 sessions, 5 min each with 2-min inter-session intervals), 5 consecutive days/week. No-exercise animals were handled and left in a stationary running wheel for 30 min/day. Animals were trained for 4 weeks using an individually adjusted, performance-based speed adaptation paradigm as described [25 (link)]. Thereafter, rats received implantation of the right external jugular vein cannula that was externalized dorsally in the suprascapular region. Brain mapping studies occurred 4 days postoperatively.
All animals were habituated to a horizontal treadmill for 4 days prior to cerebral perfusion experiments. Each day, they were individually placed on the stationary treadmill (single lane, L = 50, W = 7, H = 30 cm) for 10 min followed by 3 min of walking at 8 m/min.
Peng Y.H., Heintz R., Wang Z., Guo Y., Myers K.G., Scremin O.U., Maarek J.M, & Holschneider D.P. (2014). Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain. Frontiers in physics, 2, 72.
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2

Exercise-induced Brain Mapping

Cited 1 time
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Two weeks after the lesioning, animals assigned to the exercise group were trained in a running wheel (36 rungs of 14.6 mm diameter, 4.4° angular spacing, Lafayette Instrument, Lafayette, IN, USA) for 20 min/day (4 sessions, 5 min each with 2-min inter-session intervals), 5 consecutive days/week. No-exercise animals were handled and left in a stationary running wheel for 30 min/day. Animals were trained for 4 weeks using an individually adjusted, performance-based speed adaptation paradigm as described [25 (link)]. Thereafter, rats received implantation of the right external jugular vein cannula that was externalized dorsally in the suprascapular region. Brain mapping studies occurred 4 days postoperatively.
All animals were habituated to a horizontal treadmill for 4 days prior to cerebral perfusion experiments. Each day, they were individually placed on the stationary treadmill (single lane, L = 50, W = 7, H = 30 cm) for 10 min followed by 3 min of walking at 8 m/min.
Peng Y.H., Heintz R., Wang Z., Guo Y., Myers K.G., Scremin O.U., Maarek J.M, & Holschneider D.P. (2014). Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain. Frontiers in physics, 2, 72.
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3

Voluntary Exercise After Injury

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On day 14 postinjury, rats were given voluntary access to a running wheel (Lafayette Instruments, Lafayette, IN; Figure 1) for 6 continuous hours (3 in the light cycle, 3 in the dark cycle) every day until day 42 postinjury. The total distance run per day was measured and is presented in kilometers per hour (see supplemental Results section). A yoked control group was allowed access to a locked running wheel during the same time period.
Adkins D.L., Ferguson L., Lance S., Pevtsov A., McDonough K., Stamschror J., Jones T.A, & Kozlowski D.A. (2015). Combining Multiple Types of Motor Rehabilitation Enhances Skilled Forelimb Use Following Experimental Traumatic Brain Injury in Rats. Neurorehabilitation and neural repair, 29(10), 989-1000.
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4

Voluntary Exercise Protocol for Rats

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Identical exercise parameters were adapted from our previous published studies (Hall et al., 2014 (link); Hall and Savage, 2016 (link)). Microbead and cannulated PTD- and PF-treated rats were randomly assigned into one of two exercise conditions: (1) a voluntary exercise condition (VEx) in which a running wheel (Lafayette Instrument Company, Lafayette, IN, United States) was attached to the home cage or (2) a sedentary condition with a locked exercise wheel (Stat). Rats were pair-housed and food restricted to 16 g/rat/day. Food restriction has been shown to increase wheel running (see Sherwin, 1998 (link); Lee et al., 2002 (link)). Furthermore, rats remained in the wheel running apparatus for a period of 2-weeks, with daily running (cumulative m/day) recorded via AWM® software (Lafayette Instrument Company).
Hall J.M., Gomez-Pinilla F, & Savage L.M. (2018). Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Frontiers in Neuroscience, 12, 773.
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5

Voluntary Wheel Running in Aged Mice

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Male c57Bl/6 mice were obtained from the colony at the National Institute on Aging (Bethesda, Maryland, U.S.) at ~5 or ~25 months of age. Animals were allowed to acclimate to our facility for 2 weeks, were kept on a 12-hour light:dark cycle and were provided normal rodent chow (Harlan 7019) and water ad libitum. Following the 2-week acclimation period, mice were randomly assigned to either a sedentary cage control group (young control [YC], n=11 and old control [OC], n=12) or to a voluntary aerobic exercise group (young voluntary wheel running [YVR], n=10 and old voluntary wheel running [OVR], n=11) for 10 weeks. The animals in the voluntary aerobic exercise groups were housed in cages with access to a running wheel (Lafayette Instruments, Lafayette, IN, USA) and were permitted to exercise ad libitum. Daily wheel running was monitored using Activity Wheel Monitor software (Lafayette, IN, USA) for 72 continuous hours once per week, and daily running activity was determined as the average distance run per 24 hour period. Following the 10-week intervention period, animals were euthanized and tissues and organs were harvested for assessment of arterial function and biochemical parameters as described below.
Gioscia-Ryan R.A., Battson M.L., Cuevas L.M., Zigler M.C., Sindler A.L, & Seals D.R. (2016). Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY), 8(11), 2897-2914.
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6

Voluntary Wheel Running Behavior

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The HFX group was individually housed, and a running wheel (Lafayette Instrument Company, USA) was placed in each cage for 12 weeks. Running activities such as distance (meter) and velocity (meter per minute) were recorded in a 10-min time interval using a computerized system (Lafayette instrument computerized animal wheel monitoring system; Lafayette Instrument Co., USA).
So B., Ji L.L., Imdad S, & Kang C. (2022). Proteomic analysis of the effect of high-fat-diet and voluntary physical activity on mouse liver. PLoS ONE, 17(8), e0273049.
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7

Voluntary Running in Isolation

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From post-natal day 21 (P21) until perfusion, rats were randomly allocated to different rearing conditions within an open-top opaque plastic cage (40.64 × 50.8 × 41.91 cm) that contained a 35.56 cm diameter running wheel (Lafayette Instrument Company, Indiana, USA). All conditions were unchanged throughout experimentation (i.e., isolation and running conditions remained throughout fear conditioning, extinction, and testing periods).
Drummond K.D., Waring M.L., Faulkner G.J., Blewitt M.E., Perry C.J, & Kim J.H. (2021). Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence. Neurobiology of Stress, 15, 100367.
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8

Investigating the Effects of Social Housing and Running Wheel Access on Rats

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For Experiment 5, rats were placed into social housing conditions (SOC, n = 16) or given running wheel access (RUN, n = 13). SOC or RUN were given during the dark phase only, at the same time as environmental enrichment. For SOC, rats were placed 4 per cage in a clear guinea pig cage (20 cm height × 38 cm width × 47 cm length). The same 4 rats were housed together for the duration of SOC. For RUN, rats were placed 1 per cage in a clear guinea pig cage with a running wheel (Lafayette Instrument Co., Lafayette IN USA). Running activity was recorded via computerized Animal Wheel Monitoring System (Lafayette Instrument Co., Lafayette IN USA), see Figure S4a for running distances. During the light phase, rats were singly housed in standard cages.
Smith B.L., Lyons C.E., Correa F.G., Benoit S.C., Myers B., Solomon M.B, & Herman J.P. (2016). Behavioral and physiological consequences of enrichment loss in rats. Psychoneuroendocrinology, 77, 37-46.
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9

Automated Running Wheel Assay

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The running wheel assay followed our previously described protocol (Webster et al., 2015 (link)). Briefly, at 12–14h following the CHI or sham injury, the mice were introduced into the running wheels (Lafayette Instruments; Lafayette, IN) and data was recorded for 5 days. Computerized counting software (Lafayette Instruments; Lafayette, IN) automatically recorded the total distance run each hour by each animal, and the 1-hour blocks were combined into 1d blocks.
Bachstetter A.D., Morganti J.M., Bodnar C.N., Webster S.J., Higgins E.K., Roberts K.N., Snider H., Meier S.E., Nation G.K., Goulding D.S., Hamm M., Powell D.K., Vandsburger M., Van Eldik L.J, & Abisambra J.F. (2020). The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: primary results in wild type and rTg4510 mice, and a systematic review. Experimental neurology, 326, 113180.
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10

Circadian Wheel Running Activity

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Mice were housed in individual cages equipped with running wheels (Lafayette Instrument, Lafayette, IN), and were placed in light-tight cabinets under a 12 h light/dark cycle. After acclimation to the system, mice were subjected to continuous recording for 7 days. The locomotor activity of mice was analyzed using the ClockLab sftware (Actimetrics, Wilmette, IL).
Guo L., Cen H., Weng J., He Y., Guo X., He D., Liu K., Duan S., Yang J., Zhang X., Qin Z., Wan Y., Chen Z, & Wu B. (2023). PER2 integrates circadian disruption and pituitary tumorigenesis. Theranostics, 13(8), 2657-2672.
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