Variseed version 7

Manufactured by Agilent Technologies

Sourced in United States

Variseed version 7.1 is an advanced software solution for brachytherapy treatment planning. It provides tools for dose calculation, visualization, and optimization to assist medical professionals in the planning and delivery of brachytherapy procedures.

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Lab products found in correlation

Lightspeed ultra 16 discovery ct 750 hd, by GE Healthcare (3 mentions) Intera achieva 1.5 t intra achieva nova dual 1.5 t pulsar, by Philips (3 mentions)

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VariSeed

3 protocols using variseed version 7

Post-Implant Dosimetric Evaluation in LDR-BT

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Treatment design and post-implant dosimetric evaluation were carried out in accordance with the latest American Medical Association Task Group 43 protocols and Variseed version 7.1 (Varian Medical Systems, Palo Alto, CA, USA). For post-implantation dose measurements, computed tomography (CT) and magnetic resonance imaging (MRI) were carried out 1 month from LDR-BT. A CT with a 16- or 64-detector array CT scanner (LightSpeed Ultra 16/Discovery CT 750 HD; GE Healthcare, Milwaukee, WI, USA) was used [21 (link)]. Also, an MRI using a 5-channel SENSE cardiac coil was performed in easy-breathing conditions using a slice thickness of 3 mm and no cross-gap (Intera Achieva 1.5 T/Intra Achieva Nova Dual 1.5 T Pulsar: Philips Medical Systems, Philips Medical Systems, Eindhoven, The Netherlands) [21 (link)]. In this study, the following dosimetric parameters were evaluated: the minimum percentage of the prostate gland received at 90% (D90), the percentage of the PV receiving 100% of the specified minimum peripheral dose (V100), the percentage of the rectal volume receiving 100% of the specified dose (RV100), and the biologically effective dose (BED).

Takeuchi S., Iinuma K., Nakane K., Nakano M., Kawase M., Kawase K., Takai M., Kato D., Mori T., Takano H., Kumano T., Matsuo M, & Koie T. (2023). Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer. Current Oncology, 30(3), 2792-2800.

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Post-Implant Dosimetry for Low-Dose-Rate Brachytherapy

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Treatment planning and post-implant dosimetry were performed using the latest American Association of Physicians in Medicine Task Group 43 formalism and Variseed version 7.1 (Varian Medical Systems, Palo Alto, CA, USA). A post-implant dosimetric study using computed tomography (CT) and magnetic resonance imaging (MRI) was performed 1 month after LDR-BT. CT was performed using a CT scanner with a 16 or 64 detector array (LightSpeed Ultra 16/Discovery CT 750 HD; GE Healthcare, Milwaukee, WI, USA), and MRI under respiratory depression was performed using a five-channel SENSE cardiac coil with a slice thickness of 3 mm and no cross-gap (Intera Achieva 1.5 T/Intra Achieva Nova Dual 1.5 T Pulsar; Philips Medical Systems, Eindhoven, The Netherlands). The dosimetric parameters analyzed in this study were the biological effective dose (BED), minimum dose received by 90% of the target volume (D90), percentage of target volume receiving at least 100% of the prescribed dose (V100), minimum dose received by 30% of the urethral volume (UD30), and rectal volume receiving 100% of the prescribed dose (RV100).

Tsuchiya K., Kawase M., Nakane K., Nakano M., Iinuma K., Kato D., Takai M., Tobisawa Y., Mori T., Takano H., Kumano T., Matsuo M., Ito T, & Koie T. (2023). Chronological Changes of Lower Urinary Tract Symptoms in Elderly Patients with Prostate Cancer after Low-Dose-Rate Prostate Brachytherapy. Life, 13(7), 1507.

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Dosimetric Evaluations of LDR-BT

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Therapeutic planning and post-implant dosimetric evaluations were performed using the updated American Association of Physicists in Medicine Task Group 43 protocol and VariSeed version 7.1 (Varian Medical Systems, Palo Alto, CA, USA). A post-implant dosimetric study using computed tomography (CT) and magnetic resonance imaging (MRI) was performed one month following LDR-BT. CT was performed using a CT scanner with 16 or 64 detector arrays (LightSpeed Ultra 16/Discovery CT 750 HD; GE Healthcare, Milwaukee, WI, USA).¹⁸ (link) MRI was performed using a 5-channel SENSE cardiac coil under easy breathing with a slice thickness of 3 mm and no intersectional gap (Intera Achieva 1.5 T/Intra Achieva Nova Dual 1.5 T Pulsar; Philips Medical Systems, Eindhoven, The Netherlands).¹⁸ (link) The dosimetric parameters analyzed in this study were the minimal percentage of the dose received by 90% of the prostate gland (D90), the percentage of PV receiving 100% of the prescribed minimal peripheral dose (V100), the rectal volume receiving 100% of the prescribed dose (RV100), and BED.

Takeuchi S., Iinuma K., Nakano M., Kawase M., Kato D., Kawase K., Takai M., Nakane K., Ito M., Kumano T., Matsuo M, & Koie T. (2022). Patient age as a predictive factor in biochemical recurrence following brachytherapy: Oncological outcomes at a single center. Prostate International, 10(4), 224-228.

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