Diallyl trisulfide dats

Manufactured by Merck Group

Sourced in United States

Diallyl trisulfide (DATS) is a chemical compound used in laboratory research. It is a colorless or pale yellow liquid with a characteristic odor. DATS is a member of the organosulfur compound family and is known for its potential biological activities.

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Lab products found in correlation

Hank s balanced salt solution hbss, by Thermo Fisher Scientific (2 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (2 mentions) Trypsin edta, by Thermo Fisher Scientific (2 mentions) Mda mb 231, by American Type Culture Collection (2 mentions) Mda mb 468, by American Type Culture Collection (2 mentions) Trypan blue, by Corning (1 mentions) Cleaved caspase 3, by Cell Signaling Technology (1 mentions) Crystal violet, by Merck Group (1 mentions) Cleaved parp, by Cell Signaling Technology (1 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (1 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (1 mentions) N acetyl l cysteine, by Merck Group (1 mentions) Bcl 2, by Cell Signaling Technology (1 mentions) Cleaved caspase 9, by Cell Signaling Technology (1 mentions) Anti mouse and anti rabbit secondary antibodies, by Cell Signaling Technology (1 mentions) Cytochrome c, by Cell Signaling Technology (1 mentions) Cleaved caspase 7, by Cell Signaling Technology (1 mentions) Annexin 5 fitc apoptosis kit, by RayBiotech (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Superoxide dismutase, by Abcam (1 mentions)

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Diallyl trisulfide (4 citations)

4 protocols using diallyl trisulfide dats

Diallyl Trisulfide Apoptosis Signaling

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Diallyl trisulfide (DATS, ≥98% purity) was purchased from Sigma Aldrich (St. Louis, MO, USA). Dimethyl sulfoxide (DMSO) and phosphate-buffered saline (PBS) were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Trypan blue (0.4%, w/v, in PBS) was purchased from Corning (Manassas, VA, USA), and crystal violet and N-acetyl-L-cysteine were purchased from Sigma Aldrich. Antibodies against PARP (#9542), cleaved PARP (#5625), Bcl2 (#4223), Bak (#3814), cytochrome c (#4272), cleaved caspase 3 (#9664), cleaved caspase 7 (#9491), and cleaved caspase 9 (#52873) were purchased from Cell Signaling Technology (Danvers, MA, USA). Actin antibody (#A5441) was purchased from Sigma Aldrich. Secondary anti-mouse and anti-rabbit antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA).

Stan S.D, & Abtahi M. (2022). Diallyl Trisulfide Induces Apoptosis in Breast Ductal Carcinoma In Situ Derived and Minimally Invasive Breast Cancer Cells. Nutrients, 14(7), 1455.

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African and Caucasian TNBC Cell Lines

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MDA-MB-468 (African American TNBC cell line) and MDA-MB-231 (Caucasian American TNBC cell line) cell lines were obtained from the American Type Culture Collection (ATCC) (Rockville, MD, USA). Fetal Bovine Serum (FBS), Dulbecco’s Modified Eagles Medium (DMEM) high glucose, Diallyl Trisulfide (DATS), and Dimethyl sulfoxide (DMSO) were acquired from Sigma (St. Louis, MO, USA). Penicillin/Streptomycin, trypsin-EDTA, and Hanks Balanced Salt Solution (HBSS) were acquired from Invitrogen (Carlsbad, CA, USA). Ethanol was obtained from Cruzan International (Deerfield, IL, USA). Tumor necrosis factor alpha (TNF-α) and Annexin V-FITC apoptosis Kit (Cat# 68FT-AnnV-S100) were purchased from RayBiotech (Norcross, Ga, USA). Caspase 3, 8 and 9 multiplex activity Assay kit (Fluorometric) (Lot# GR3387283–1) were purchased from Abcam (Cambridge, MA, USA).

KANGA K.J., KANGA L.H., MENDONCA P., SOLIMAN K.F., FERGUSON D.T., REED S.L, & DARLING-REED S. (2023). Attenuative Effect of Diallyl Trisulfide on Caspase Activity in TNF-α-induced Triple Negative Breast Cancer Cells. Anticancer research, 43(6), 2393-2405.

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Colorectal Cancer Therapeutic Screening

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Distearoylphosphatidylcholine (DSPC), 1,2-distearoyl-sn-glycero-3-phosphatiylethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-PEG₂₀₀₀) and cholesterol (Chol), doxorubicin, azoxymethane (AOM), and diallyl trisulfide (DATS) were purchased from Sigma-Aldrich (St. Louis, MO, USA). The adenosine deaminase (ADA), lactate dehydrogenase (LDH), superoxide dismutase (SOD) assay, catalase (CAT) assay, lipid peroxidation (MDA) assay, glutathione peroxidase 1 (GPx1) assay, gamma glutamyl transferase (GGT), 5′-nucleotidase (CD73) activity assay and cell cytotoxicity assay (CAA) kit, were procured from Abcam (Cambridge, MA, USA). Dulbecco’s modified Eagle medium (DMEM) was purchased from Santa Cruz Biotechnology Inc, Heidelberg, Germany. Foetal bovine serum (FBS), streptomycin/penicillin, amphotericin-B were procured from Life Technologies, USA. HT-29 (ATCC HTB-38) and RKO (ATCC CRL-2577) were commercially purchased ATCC (American Type Culture Collection), Manassas, VA, USA.

Alrumaihi F., Khan M.A., Babiker A.Y., Alsaweed M., Azam F., Allemailem K.S., Almatroudi A.A., Ahamad S.R., Alsugoor M.H., Alharbi K.N., Almansour N.M, & Khan A. (2022). Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis. Molecules, 27(7), 2192.

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Investigating Breast Cancer Cell Lines

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MDA-MB-231 (Caucasian American TNBC cell line) and MDA-MB-468 (African American TNBC cell line) were acquired from the American Type Culture Collection (ATCC) (Rockville, MD, USA). Dimethyl sulfoxide (DMSO), Fetal Bovine Serum (FBS), Dulbecco’s Modified Eagles Medium (DMEM) high glucose, diallyl trisulfide (DATS), and Alamar blue were acquired from Sigma (St. Louis, MO, USA). Penicillin/Streptomycin, trypsin-EDTA, and Hanks Balanced Salt Solution (HBSS) were obtained from Invitrogen (Carlsbad, CA, USA). Ethanol was acquired from Cruzan International (Deerfield, IL, USA). Human cytokine arrays, human recombinant TNF-α, and ELISA assays for MCP-1 (Cat# ELH-MCP1–1) were acquired from RayBiotech (Norcross, GA, USA). The PCR primers and iScript advanced reverse transcriptase kit were obtained from Bio-Rad (Hercules, CA, USA).

KANGA K.J., MENDONCA P., SOLIMAN K.F., FERGUSON D.T, & DARLING-REED S.F. (2021). Effect of Diallyl Trisulfide on TNF-α-Induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells. Anticancer research, 41(12), 5919-5933.

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