Ultrasonography was performed with an
APLIO XG SSA-790A (Toshiba Medical Systems Corporation, Tochigi, Japan) combined with a 7.5-MhZ linear electronic scan probe
PLT-604AT (Toshiba Medical Systems Corporation). Low echogenicity of the thyroid was rated on a four-grade scale, as described by Yoshida et al. (12 (
link)): Grade 0, diffuse high-amplitude echoes throughout the lobe of the thyroid; Grade 1, low-amplitude and nonuniform echoes in the whole or several regions of the thyroid; Grade 2, several sonolucent regions in the thyroid; and Grade 3, no apparent echoes or very-low-amplitude echoes throughout the thyroid. The peak systolic velocity (PSV) of the superior thyroid artery (STA), as a marker of thyroid blood flow status, was measured. The sample volume was set at the middle of the vessel, and the Doppler angle was adjusted to ≤60°. The STA-PSV values of the left and right lobes of the thyroid were averaged to obtain the mean STA-PSV. Transverse scanning was conducted to maximize the anteroposterior and transverse dimensions, followed by calculation of the size of each thyroid lobe in mm
2 using the following formula: anteroposterior dimension × transverse dimension. The summed sizes of the right and left lobes were adapted as the thyroid size.
Torimoto K., Okada Y., Kurozumi A., Narisawa M., Arao T, & Tanaka Y. (2017). Clinical Features of Patients with Basedow's Disease and High Serum IgG4 Levels. Internal Medicine, 56(9), 1009-1013.