Telmisartan was purchased from Molekula Limited (Darlington, UK) and sulfamerazine from Sigma-Aldrich (Steinheim, Germany). HPLC-grade tetrahydrofuran (THF) was purchased from Sigma-Aldrich (Steinheim, Germany). Copovidone and Soluplus were purchased from BASF (Ludwigshafen, Germany).
Soluplus
Manufactured by BASF
Sourced in Germany, United States, China, India
Soluplus is a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. It is a solubilizing agent that can be used to enhance the solubility and bioavailability of poorly water-soluble drugs.
Automatically generated - may contain errors
Lab products found in correlation
Kollidon va64, by BASF (11 mentions)
Acetonitrile, by Thermo Fisher Scientific (9 mentions)
Methanol, by Merck Group (8 mentions)
Methanol, by Thermo Fisher Scientific (8 mentions)
Poloxamer 407, by BASF (5 mentions)
Poloxamer 188, by BASF (4 mentions)
Transcutol hp, by Gattefosse (4 mentions)
Sodium hydroxide (naoh), by Merck Group (4 mentions)
Formic acid, by Thermo Fisher Scientific (4 mentions)
Poloxamer 188, by Merck Group (3 mentions)
Kollidon 12 pf, by BASF (3 mentions)
Cremophor el, by BASF (3 mentions)
Eudragit epo, by Evonik (3 mentions)
Kolliphor p188, by BASF (3 mentions)
Cremophor rh40, by BASF (3 mentions)
Kolliphor p407, by BASF (3 mentions)
Formic acid, by Merck Group (3 mentions)
Lutrol f68, by BASF (3 mentions)
Cremophor el, by Merck Group (3 mentions)
Acetonitrile, by Merck Group (3 mentions)
111 protocols using soluplus
1
Pharmaceutical Compound Synthesis Protocol
2
Formulation of Amorphous Solid Dispersions
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TMP (water solubility ≈ 50 ng/mL; agglomerated particles (sieved fraction <355 μm) consisting of sub-micrometric size crystals with Dv90 < 1 μm); Chiesi Farmaceutici S.p.A., Parma, I); low viscosity hydroxypropyl cellulose (NISSO HPC SSL, Nisso Chemical Europe GmbH, Duesseldorf, D; HPC); hydroxypropyl methyl cellulose acetate succinate (AQUOT-LG®; Shin-Etsu, Tokyo, J; HPMCAS); polyethylene oxide (Sentry Polyox™ WSR N10 LEO NF, Dupont, Paris, F; PEO); low viscosity polyvinyl alcohol (Gohsenol® EG 03P, Mitsubishi Chemicals, Tokyo, J; PVA); polyvinyl alcohol-polyethylene glycol graft copolymer (Kollicoat® IR, BASF, Ludwigshafen, D; KIR); polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soluplus®, BASF, Ludwigshafen, D; SLP); polyvinylpyrrolidone (Kollidon® VA 64, BASF, Ludwigshafen, D; KVA); glycerol (Pharmagel, Milan, I; GLY); polyethylene glycols with different molecular weights (Clariant Masterbatches, Milan, I;, PEG 400 and PEG 8000, respectively); Dextrates (EMDEX®, JRS Pharma, Rosenberg, D; EMD); Isomalt (GalenIQ™ 810, Beneo-Palatinit GmbH, Mannheim, D; GIQ); Potato dextrins (Tackidex®, Roquette, Lestrem, F; TCK); Cetrimonium bromide (VWR International, Milan, I; CTAB).
3
Curcuminoid-Loaded Mucoadhesive Formulation
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MFC was prepared by mixing polyethylene glycol 400 and propilenglycol (1:1, v/v) in a heated reactor (65–70 °C). Then, 9.0% (w/v) poloxamer 407 (Basf, Ludwigshafen, Germany) was added to the mixture under mechanical stirring until complete dispersion. After that, curcuminoids from C. longa L. extract (>95% curcuminoid content, Gamma Comércio Importação & Exportação LTDA, São Paulo, Brazil) was added to the organic phase and pH was adjusted by using 0.1 M citric acid (pH 6.5). The final concentration of curcuminoids was 25 mg/mL. An aqueous fraction was prepared by dispersing 6% (w/v) of poloxamer 407 in purified water, under constant stirring. After dispersion, Soluplus® (Basf, Ludwigshafen, Germany), sodium metabisulphite and sodium bisulphite were added under stirring. The aqueous fraction was then heated up to 65 °C and poured into organic fraction. The mixture was stirred for 30 min. MFC was then bottled in ambar flask and stored at room temperature until use. A blank mucoadhesive formulation (control) was prepared as described above, but without adding curcuminoids extract.
4
Corneal Drug Delivery Protocol
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CPXb was bought from Acros Organics (New Jersey, USA), and CPXs was acquired from Cayman Chemical Company (Michigan, USA). Soluplus was kindly donated by BASF SE (Ludwigshafen, Germany). Poly-vinyl alcohol (PVA), polycaprolactone (PCL), gelatin from bovine skin, and chitosan were purchased from Sigma-Aldrich (Missouri, USA), and propylene glycol (PG), polyethylene glycol (PEG), hydroxy ethyl cellulose (HEC), and hydroxy propyl methyl cellulose (HPMC) were purchased from Fagron Iberica (Barcelona, Spain). Organic solvents such as DMSO and chloroform were purchased from Sigma-Aldrich (Missouri, USA). For the phosphate-buffered saline (PBS) used, sodium chloride, potassium chloride, sodium phosphate dibasic, and potassium phosphate monobasic were purchased from Scharlab (Barcelona, Spain). Ultrapure water used throughout the studies was obtained from a Q-POD dispenser (Merck Millipore, Burlington, MA, USA). Acetonitrile for the HPLC mobile phase was purchased VWR International (Radnor, PA, USA). Dialysis membranes (Spectra/Por molecular porous membrane tubing) for in vitro release studies were acquired from Repligen (MA, USA). Corneas were from porcine eyes procured from a local slaughterhouse Mercavalencia (Valencia, Spain).
5
Formulation development of amorphous solid dispersions
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PCM (lot 1511337) was purchased by Purifarma (São Paulo, Brazil), and MTL (lot FN 81700006) was provided by Purifarma (Anápolis, Brazil). Plasdone® K-29/32 (poly (vinylpyrrolidone-co-vinyl acetate) (PVPVA), lot 002177615) was donated by Ashland Specialty Ingredients (Covington, LA, USA), Eudragit® L100 (EUL, methacrylic acid-methyl methacrylate copolymer, lot B111003013) was provided by Evonik (Essen, Germany), Soluplus® (SOL, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol copolymer, lot 84414368E0) was a gift from BASF (Ludwigshafen, Germany), and Parteck® MXP (PVA, polyvinyl alcohol, lot F1952064) was donated by Merck (Darmstadt, Germany).
6
Formulation of Carbamazepine Solid Dispersions
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Soluplus (Lot number: 65511368E0) and polyvinylpyrrolidone vinyl acetate copolymer (PVP-VA), that is, Kollidon VA 64 (Lot number: 46581856Po), were procured from BASF SE, Germany. Methocel premium (CR, USA) was procured from Dow Chemicals, Michigan. Carbamazepine (Lot number: SLBB3655V) was purchased from Sigma Aldrich, USA. Magnesium stearate (Lot number: J03970) was procured form Mallinckrodt, USA.
7
Natamycin Solubility Enhancement via Polymer Blends
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Natamycin (665.73 g/mol) was obtained from AK Scientific (San Francisco, CA, USA). Soluplus® (115,000 g/mol) and Pluronic® P103 (EO17PO60EO17; 4950 g/mol) were provided from BASF (Ludwigshafen, Germany). Sodium chloride, MgCl2·6H2O, and acetonitrile were provided from Scharlab SL (Barcelona, Spain); NaOH, KH2PO4, NaHCO3, CaCl2·2H2O and NaH2PO4·H2O were provided from Merck (Darmstadt, Germany); KCl from Prolabo (Fontenay-Sous-Bois, France); phosphate-buffered saline (PBS) was provided from Sigma (St. Louis, MO, USA); penicillin and streptomycin were provided from Gibco (Grand Island, NY, USA), and ethanol absolute was provided from Panreac (Barcelona, Spain). α-Cyclodextrin (αCD) was obtained from Wacker Chemie (Munich, Germany).
Phosphate buffer pH 6.4 was prepared by mixing 250 mL of solution A (0.2 M 62.5 mL KH2PO4) and solution B (0.2 M 16.4 mL NaOH) with water. Carbonate buffer pH 7.2 was prepared by mixing buffer solution A (100 mL; 1.24 g NaCl, 0.071 g KCl, 0.02 g NaH2PO4, 0.49 g NaHCO3) and buffer solution B (100 mL; 0.023 g CaCl2, 0.031 g MgCl2).
Phosphate buffer pH 6.4 was prepared by mixing 250 mL of solution A (0.2 M 62.5 mL KH2PO4) and solution B (0.2 M 16.4 mL NaOH) with water. Carbonate buffer pH 7.2 was prepared by mixing buffer solution A (100 mL; 1.24 g NaCl, 0.071 g KCl, 0.02 g NaH2PO4, 0.49 g NaHCO3) and buffer solution B (100 mL; 0.023 g CaCl2, 0.031 g MgCl2).
8
Formulation of Simulated Lachrymal Fluid
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ALA ! 99%, AOT 98% (444.56 g/mol), and phosphate buffer saline were from Sigma-Aldrich Company (Steinheim, Germany); Soluplus (115,000 g/mol) from BASF (Ludwigshafen, Germany); NaCl 99%, NaOH 98%, KCl 99.5%, and NaH 2 PO 4 98% from Panreac Quimica SLU (Castellar del Valles, Spain); NaHCO 3 from Guinama (La Pobla de Vallbona, Spain), CaCl$2H 2 O 99.5% from Merck (Darmstadt, Germany); and ethanol absolute from Panreac (Barcelona, Spain). Water was purified using reverse osmosis (resistivity >18 MU$cm, MilliQ, Millipore ® Spain). Simulated lachrymal fluid (SLF) was prepared with the following composition: 6.78 g/L NaCl, 2.18 g/L NaHCO 3 , 1.38 g/L KCl, and 0.084 g/L CaCl$2H 2 O with pH 7.8. 26 Carbonate buffer pH 7.2 was prepared by mixing buffer solution A (100 mL; 1.24 g NaCl, 0.071 g KCl, 0.02 g NaH 2 PO 4 , 0.49 g NaHCO 3 ) and buffer solution B (100 mL; 0.023 g CaCl 2 , 0.031 g MgCl 2 ).
9
Formulation and Evaluation of ABZ Tablets
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10
Dexibuprofen Solubility Enhancement Formulations
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Dexibuprofen was gifted by Global Pharmaceuticals, Islamabad Pakistan. Gelucire 44/14® and Gelucire 48/16® were received as gift samples from Gattefossè, France. Poloxamer 188® was procured from Sigma Aldrich. Soluplus® was kindly provided by BASF (Ludwigshafen, Germany). Grace Discovery Sciences (United States) generously provided Syloid 244FP®, Syloid XDP3150®, and Syloid AL1FP®. Monobasic potassium phosphate was purchased from Daejung Reagents Chemicals and Metals Co., Ltd., Korea. Methanol, sodium hydroxide, and dichloromethane were acquired from Sigma Aldrich. Hydrochloric acid was procured from Lab-Scan analytical sciences.
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