Tanshinone 1

Manufactured by Yuanye Bio-Technology

Sourced in China

Tanshinone I is a naturally occurring compound derived from the roots of the Salvia miltiorrhiza plant. It is a bioactive compound that has been extensively studied for its potential therapeutic properties. As a laboratory reagent, Tanshinone I can be used for research purposes to investigate its biological activities and potential applications.

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Lab products found in correlation

2 protocols using tanshinone 1

Investigating Multitargeted Anticancer Potentials

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Sunitinib, veliparib, olaparib, mefloquine, simvastatin, dihydroartemisinin, tanshinone I, cryptotanshinone, gossypol and docetaxel were purchased from Selleck Chemicals. Anti-FoxO3a (cat. no. 12829), anti-α/β-tubulin (cat. no. 2148) and anti-Bcl-2 (cat. no. 15071) antibodies were purchased from Cell Signaling Technology, Inc. phosphorylated (p)FoxO3a were from Abcam Inc. (cat. no. ab154786). Anti-PARP1 (cat. no. sc-8007) was obtained from Santa Cruz Biotechnology, Inc. tanshinone I, dioscin and simvastatin were obtained from Shanghai YuanYe Biotechnology Co., Ltd. D MEM, RPMI-1640, MEM and FBS were obtained from Gibco; Thermo Fisher Scientific, Inc. MTS was purchased from Shanghai BestBio (cat. no. BB-4204-3). The secondary fluorescent antibodies, IRDye 800CW goat anti-mouse (cat. no. 926-32210) and IRDye 800CW goat anti-rabbit (cat. no. 926-32211) were from were from LI-COR. All other laboratory reagents in common use were of domestic analytical pure grade.

Zhang Y., Huang J., Huang Y., Zhang S., Wu W., Long H., Duan X., Lai Y, & Wu W. (2020). Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression. Molecular Medicine Reports, 23(1), 40.

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HPLC Analysis of Medicinal Compounds in Salvia miltiorrhiza

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HPLC-grade acetonitrile was purchased from Merck Co., Inc. (Darmstadt, Germany). HPLC-grade phosphoric acid and analytical-grade methanol were purchased from Tianjin Komiou Chemical Reagent Co., Ltd. (Tianjin, China). Six reference compounds (rosmarinic acid, salvianolic acid B, dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA, HPLC ≥ 98%) were purchased from Shanghai Yuan ye Bio-Technology Co., Ltd. (Shanghai, China). Ultrapure water was generated with a You pu Ultrapure Water System (Chengdu, China).
The fresh roots and rhizomes of one-year-old S. miltiorrhiza plants were harvested in 2020 in Tongchuan (Tongchuan, China) in April, the best time of year for the harvest of the medicinal parts of S. miltiorrhiza, and were identified by Professor Zongsuo Liang (Zhejiang Sci-tech University). After removing soil and impurities, the samples were divided into 16 batches according to their weight, size and thickness.

Zhang L., Zhang X., Begum N., Xia P., Liu J, & Liang Z. (2022). Effects of Different Processing Methods Based on Different Drying Conditions on the Active Ingredients of Salvia miltiorrhiza Bunge. Molecules, 27(15), 4860.

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