Ge advance

Manufactured by GE Healthcare

Sourced in United States

The GE Advance is a versatile lab equipment designed for a range of applications. It provides essential functionalities for laboratory professionals to conduct their work efficiently. The core function of the GE Advance is to facilitate reliable and consistent data gathering and analysis within the laboratory setting.

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Lab products found in correlation

Intera 1.5t scanner, by Philips (1 mentions) E soft workstation, by Siemens (1 mentions) True point biograph 16, by Siemens (1 mentions)

Close spelling variants of this product

GE Advance PET scanner Prodigy Advance Model GE GE Advance tomograph GE Lunar Prodigy Advance enCORE™ Version 13.60). GE Advance scanner GE Lunar Prodigy Advance

6 protocols using ge advance

PET Imaging of [11C]-Acetate Biodistribution

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[¹¹C]-acetate was synthesized according to our previous publication [15 (link)].
All patients underwent PET imaging in the supine position after a 6 h fast. A dedicated PET system (GE Advance, General Electric Medical Systems, Milwaukee, WI, USA) was used. Emission scans from mid-thigh to skull base were acquired 10 min after intravenous injection of 8 MBq of [¹¹C]-acetate per kg of body weight with 5 min per scanner bed position. PET images were reconstructed using ordered subset expectation maximization (OSEM) with all relevant corrections applied.

Li S., Peck-Radosavljevic M., Ubl P., Wadsak W., Mitterhauser M., Rainer E., Pinter M., Wang H., Nanoff C., Kaczirek K., Haug A, & Hacker M. (2017). The value of [11C]-acetate PET and [18F]-FDG PET in hepatocellular carcinoma before and after treatment with transarterial chemoembolization and bevacizumab. European Journal of Nuclear Medicine and Molecular Imaging, 44(10), 1732-1741.

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PET and MRI Imaging Protocols

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[¹⁸F]FDG was synthesised with an automatic apparatus as described by Hamacher et al [16 (link)]. PET images were acquired using the PET scanner GE Advance (General Electric Medical Systems, Milwaukee, WI, USA), which has a transaxial resolution of 3.8 mm (full width at half maximum [FWHM]) and slice width of 4.2 mm in the centre of the imaging field [17 (link)]. A transmission scan of 5 min was performed before the emission scan to correct for the tissue attenuation of gamma photons. All image data were corrected for dead time, decay and photon attenuation. MRI was performed using a Philips Intera 1.5 T scanner (Best, the Netherlands). The whole body of a participant was scanned with axial in-and-out-of-phase images with a repetition time of 120 ms, echo times of 2.3 ms and 4.63 ms, a slice thickness of 10 mm and a matrix 530 × 530 mm².

Mäkinen J., Hannukainen J.C., Karmi A., Immonen H.M., Soinio M., Nelimarkka L., Savisto N., Helmiö M., Ovaska J., Salminen P., Iozzo P, & Nuutila P. (2015). Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery. Diabetologia, 58(5), 1055-1062.

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Evaluating FDG-PET for Liver Tumor Detection

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All patients were imaged on a state-of-the-art, high resolution, high sensitivity dedicated BGO PET system, the GE Advance (GE Medical Systems, Milwaukee, WI, USA), after injection of 10–15 mCi (370–555 MBq) ¹⁸F-FDG. Iteratively reconstructed images of the FDG-PET scans were read with the nuclear medicine physician blinded to the results of other scanning. FDG-PET results were quantified by calculating the maximum standardized uptake value (SUV) for lesions detected (28 (link)). All modalities were also graded on a 5-point ordinal confidence scale (0–4), with a score of 0–2 classified as a negative scan and a score of 3–4 regarded as a positive scan.
At the time of surgery, the number and site of each tumor within the liver were recorded. Serial thin slices of the resected specimen were then examined and all tumor nodules identified (and confirmed as cancers by histopathology). These pathologic findings were correlated with the blinded FDG-PET reading.

Akhurst T., Gönen M., Baser R.E., Schwartz L.H., Tuorto S., Brody L.A., Covey A., Brown K.T., Larson S.M, & Fong Y. (2022). Prospective evaluation of 18F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases. Hepatobiliary Surgery and Nutrition, 11(4), 539-554.

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Whole-Body PET Imaging Using [18F]-FDG

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The same whole body PET scanner (GE Advance, General Electric Medical Systems, Milwaukee, WI, USA) was used. The patients had been fasted for at least 4 h before the injection of [¹⁸F]-FDG PET. [¹⁸F]-FDG PET was administered intravenously in a dosage of 5.5 MBq/kg of body weight in patients. Subsequently, the acquisition of whole body images started 50 min later. Emission and transmission scans were performed in a two-dimensional imaging method for data acquisition. While emission images were acquired for 3 min per bed position, each post-emission transmission scan was obtained for 1 min per bed position; whole-body scanning was performed from skull base to upper thigh in all patients using five or six bed positions according to the height of each patient. Reconstruction of the data was performed by using the ordered subset expectation method (OSEM) with 16 subsets, three iterations and 128 × 128 matrix (pixel) size.

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Whole-Body PET/CT Imaging of Amino Acid Transport

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All patients were examined with a whole-body PET scanner, GE Advance (GE Healthcare, Waukesha, WI, USA), or with a whole-body PET/CT scanner, Siemens True Point Biograph 16 (Siemens/CTI, Erlangen, Germany). All subjects received an intravenous injection of MeAIB (513.6 ± 65.6 MBq) or MET (533.9 ± 35.0 MBq). Brain PET/CT images were acquired 20 min after the radiotracer injection in 1 bed position in both study. Emission images were acquired for 5 min per bed position. The data were reconstructed using the ordered subsets expectation-maximization method using eight subsets, two iterations, and an array size of 256 × 256. For the attenuation correction of PET/CT fusion images, the CT component was performed according to a standard protocol with the following parameters: 140 kV; 50 mAs; tube rotation time, 0.5 s per rotation; slice thickness, 5 mm; and gap, 2 mm. An E-soft workstation (Siemens, Nashville, TN, USA) was used to construct PET/CT fusion images.

Nishii R., Higashi T., Kagawa S., Arimoto M., Kishibe Y., Takahashi M., Yamada S., Saiki M., Arakawa Y., Yamauchi H., Okuyama C., Hojo M., Munemitsu T., Sawada M., Kobayashi M., Kawai K., Nagamachi S., Hirai T, & Miyamoto S. (2018). Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. Contrast Media & Molecular Imaging, 2018, 1292746.

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PET Imaging of [11C]-(+)-PHNO Synthesis and Analysis

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[¹¹C]-(+]-PHNO was synthesized as described earlier^{31 (link)}. Quality control was in accordance with European Pharmacopoeia. PET images were acquired on a GE Advance scanner (General Electric Medical Systems, Milwaukee, WI). Emission data were acquired over 90 min after bolus-injection of 309 [81] MBq (mean [SD]) [¹¹C]-(+)-PHNO. Raw data were reconstructed by filtered-back projection to yield dynamic images in 15 consecutive one-minute frames followed by 15 five-minute frames. With exception of two patients who chose to terminate their participation early, all subjects underwent T1 and proton density (PD) weighted 3 T magnetic resonance (MR) imaging (see Supplemental Material).

Weidenauer A., Bauer M., Sauerzopf U., Bartova L., Nics L., Pfaff S., Philippe C., Berroterán-Infante N., Pichler V., Meyer B.M., Rabl U., Sezen P., Cumming P., Stimpfl T., Sitte H.H., Lanzenberger R., Mossaheb N., Zimprich A., Rusjan P., Dorffner G., Mitterhauser M., Hacker M., Pezawas L., Kasper S., Wadsak W., Praschak-Rieder N, & Willeit M. (2020). On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study. Translational Psychiatry, 10, 2.

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