All salts for Krebs solutions were of AnalaR grade or higher and obtained from BDH, Poole, or Fisons, Loughborough. Chloroquine diphosphate, (±) adrenaline HCl, urethane (ethyl carbamate), Tween 80, N,N‐dimethylacetamide and propylene glycol were obtained from Sigma, Poole. Heparin sodium (Multiparin of 5,000 IU·ml−1) injection was obtained from CP Pharmaceuticals, Wrexham. MTBE was purchased from Fisons, Loughborough; Ro5‐4864 was purchased from Fluka Chemika, Gillingham, Dorset; Hypnorm (fentanyl/fluanisone) was from Janssen Animal Health, Petteridge, Kent; Amprol Plus (Amprolium HCl/ethopabate) was from Merk Sharp & Dohme, Hertfordshire; and sodium pentobarbitone was from RMB Animal Health Ltd, Dagenham. 7‐Chloro‐4‐(5‐diethylamino‐1‐methylpentyl‐amino)‐quinoline diphosphate was a gift from the Walter Reed Army Institute of Research, Washington D.C.; and clonazepam and diazepam were gifts from Hoffman‐La Roche, Basel.
Clonazepam
Manufactured by Roche
Sourced in Denmark, France
Clonazepam is a benzodiazepine medication used as a laboratory reagent. It is a central nervous system depressant that can be used for various research and analytical purposes. The core function of Clonazepam is to serve as a chemical compound for experimental and investigative applications in controlled settings.
Automatically generated - may contain errors
Lab products found in correlation
Chloroquine diphosphate, by Merck Group (1 mentions)
Propylene glycol, by Merck Group (1 mentions)
Urethane ethyl carbamate, by Merck Group (1 mentions)
N n dimethylacetamide, by Merck Group (1 mentions)
Tween 80, by Merck Group (1 mentions)
Hypnorm, by Johnson & Johnson (1 mentions)
Diazepam, by Roche (1 mentions)
Ketamine, by Merck Group (1 mentions)
Amitriptyline, by Merck Group (1 mentions)
Duloxetine, by Merck Group (1 mentions)
3 protocols using clonazepam
1
Reagents and Chemicals Used in Study
2
Clonazepam Enhances Passive Avoidance
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Thirty minutes prior to passive avoidance training, the mice received 0.0625 mg/kg clonazepam intraperitoneally (Roche, Hvidovre, Denmark) dissolved in 0.9% sterile saline (vehicle) or vehicle alone.
3
Pharmacological Evaluation of Analgesic Agents
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Cyclotraxin B (Bio S&T, Montreal, Canada), pregabalin (Sequoia, Pangbourne, UK), morphine (Pharmacie Centrale des Hôpitaux de Paris, France), tapentadol (Grünenthal, Aachen, Germany), agomelatine (Servier, Suresnes, France), ketamine, duloxetine and amitriptyline (Sigma-Aldrich, Saint-Quentin Fallavier, France), clonazepam (Roche, Basel, Switzerland) were administered using routes and doses previously reported to be active at their respective molecular targets (Cazorla et al., 2010; de Bodinat et al., 2010; Lau et al., 2013; Michot et al., 2013; M'Dahoma et al., 2014) . Drugs were injected i.p. in a volume of 1 mL/kg, except morphine which was injected subcutaneously (1 mL/kg, s.c.). Cyclotraxin B, morphine, tapentadol, pregabalin, ketamine and amitriptyline were dissolved in 0.9 % NaCl.
Agomelatine and duloxetine were dissolved in 1% hydroxyethylcellulose (HEC) in water, and clonazepam in ethanol:water (50:50). Control animals received respective vehicles using the same routes of administration.
Agomelatine and duloxetine were dissolved in 1% hydroxyethylcellulose (HEC) in water, and clonazepam in ethanol:water (50:50). Control animals received respective vehicles using the same routes of administration.
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