3D computer-aided design (CAD) models of the cartridge were designed using Autodesk Inventor Professional 2019 software (Autodesk, Inc., San Rafael, CA, USA). The CAD data were exported in STL format for the 3D printer. A ProJet MJP 3600 MAX 3D printer (3D Systems, Rock Hill, SC, USA) in its maximum resolution mode (XHD mode; z-axis resolution of 16 μm) was used for cartridge printing using a translucent and biocompatible ultraviolet (UV)-curable acrylic resin (Visijet M3 Crystal; 3D Systems). The cartridge printing process took approximately 4 h in the XHD mode. The cartridge is composed of separate top and bottom parts. We also fabricated a transparent 3D-printed cartridge using the same CAD data for visualizing flow in the channels. Owing to material (RGD−810 VeroClear; Stratasys, Eden Prairie, MN, USA) and printer (Objet500 Connex3; Stratasys) limitations, transparent materials were printed with a 30 µm z-axis resolution.
Inventor professional 2019
Manufactured by Autodesk
Sourced in United States
Autodesk Inventor Professional 2019 is a 3D mechanical design and engineering software. It provides tools for creating and simulating 3D mechanical designs.
Automatically generated - may contain errors
Lab products found in correlation
6 protocols using inventor professional 2019
1
3D-Printed Microfluidic Cartridge Fabrication
2
Additive Manufacturing of Polymer Parts
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Autodesk Inventor Professional 2019 (Autodesk, San Rafael, CA, USA) was used to design all polymer material parts 3D-printed in this work. The designs are subsequently converted into a standard tessellation language (STL) file by the software and loaded into the ASIGA composer software. Two digital light projector (DLP)-based printers (Asiga PICO2HD and PICO2; ASIGA, Alexandria, Australia) are used for resin processing and additive manufacturing, respectively. Different printing parameters were adjusted in the composer software and provided control over layer thickness, separation distance, and exposure time. After the printing process, all objects were washed with IPA to remove excess resin followed by post-curing the object for 300 s with 10 UV-light flashes per second using an Otoflash G171 chamber (NK-Optik GmbH, Baierbrunn, Germany). Following this procedure, the printed parts were ready for use.
3
3D Printed Dissolution Apparatus Design
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Squares with the dimensions shown in Table 1 were designed using Autodesk Inventor® Professional 2019 (Autodesk Inc., USA). In Fig. 1 the designed rectangles can be seen, four intact films and one film with a square shaped void in the middle. The two films of 100 mm 3 were designed to examine design effect on the dissolution profile. The designs were saved as stereolithography (.stl) files and exported into the RepetierHost V1.61 (Germany) for determination of the printing parameters and sliced into Gcode files that are readable by the EXT 3D printer software. The printing settings were set to a layer height of 0.5 mm, with a density and first layer height of 100%, first layer extrusion width of 30% and 1 perimeter. The printer was set to print with a speed of 8 mm/s in a rectilinear pattern. Time to print the prepared designs were 1 min 13 sec for the smallest design and 5 min 7 sec for the biggest design. The four first squares from left to right are designed as 25, 50, 100 and 200 mm 3 squares, and the square furthest to the right is designed as 100 mm 3 with a void.
4
Dual-component 3D-printed implants
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Two-compartment implants were designed using the CAD software Inventor® Professional 2019 (Autodesk®, San Rafael, CA, USA). As the slicing software, Simplify3D® software (version 4.0) (Cincinnati, OH, USA) was used. Printing was performed using the Prusa i3 MK3S FDM printer (Prusa Research, Prague, Czech Republic). The printer was equipped with a multi-material unit (MMU) 2S, enabling a dual-component print of the drug-free shell and drug-loaded network inlay. An ooze shield was printed on every layer around each implant to prevent cross-contamination after each automatic filament change (Figure 1 ). Printing temperature was 185 °C, layer height was 200 µm, and nozzle diameter was 400 µm. Infill density was 100%. The rectilinear fill pattern was printed at 45° for the drug-free shell and 90° for the drug-loaded network inlays. More detailed printing settings can be found in the supplementary material (Table S2) .
5
3D Printed Auxetic Skeleton Designs
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The plastic skeletons were designed by CAD software (Autodesk Inventor Professional 2019; https://www.autodesk.com/products/inventor/ ). Handles were designed on both ends of the geometric part. The geometry of the skeleton excluding the handles had a width of 24.5 mm, length of 60 mm, and thickness of 2 mm (Figure S1 a). The functional geometries (auxetic, offset rectangle, and honeycomb) were designed by changing the angle (θ = 40°–140°) of the joints (Figure S1 b). All interconnects have a width of 0.5 mm. A spacer was designed around the exterior of the skeleton to fix the skeleton in the middle of the matrix and maintain a total composite thickness of 4 mm and was removed prior to sample testing. These designed skeletons were 3D printed (AGILISTA-3000, Keyence Co.). After printing, the skeletons were washed in deionized water to remove the support material and dried.
6
3D Hydrogel Chip Fabrication
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3D hydrogel chips were designed using CAD software (Inventor Professional 2019, Autodesk, USA). The 3D stereolithographic hydrogel printing method, cytotoxicity assessment and perfusion setup have been described in our previous work. 4 The pre-polymer solution was adapted and consisted of 200 mg/mL poly(ethylene glycol) diacrylate (PEGDA; M n 700 g/mol; Sigma-Aldrich), 11.25 mg/mL quinoline yellow (Sigma-Aldrich), 5 mg/mL lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, Sigma-Aldrich) in water and optimized exposure settings of 4.5 s per printed layer with a step height of 20 µm.
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