Olanzapine

Chlorpromazine, clozapine, olanzapine, and quetiapine were purchased from Cerilliant (Round Rock, TX, USA). DesmethylChlorpromazine and 7-hydroxy-Chlorpromazine were acquired from TRC Canada (Toronto, ON, Canada). N-desmethylclozapine was obtained from Sigma-Aldrich (St. Louis, MO, USA). N-desmethylolanzapine was purchased from Santa Cruz Biotechnology (Dallas, TX, USA). Norquetiapine was acquired from Biovision (Milpitas, CA, USA). The internal standards Chlorpromazine-d3 and quetiapine-d8 were obtained from Cerilliant (Round Rock, TX, USA). Butyl methacrylate (BMA) (99%), ethyleneglicol dimetacrylate (EGDMA, 98%), 1-propanol (HPLC grade), vinyltrimethoxysilane (VTMS) 1,4-butendiol (99%), and 2,2-azobisisobutylnitrile (AIBN) were purchased from Sigma–Aldrich (St. Louis, MO, USA). Fused silica capillary (530 μm i.d. × 10 cm) was acquired from NST (São Paulo, Brazil). Acetonitrile, methanol (HPLC grade), ammonium acetate, and formic acid were supplied by JTBaker (Phillisburg, NJ, USA). Hydrochloric acid and sodium hydroxide were purchased from Sigma–Aldrich (St. Louis, MO, USA). Aqueous solutions were prepared with ultrapure water from a Milli-Q, Millipore system (18.2 MΩ cm) (São Paulo, SP, Brazil).

Acetonitrile and chloroform gradient grade solvents were purchased from Merck^® (Madrid, Spain) and sodium chloride from Panreac^® (Barcelona, Spain). Fluoxetine, venlafaxine, mirtazapine, sertraline, citalopram, olanzapine, paroxetine and proadifen (SKF), used as internal standard, were obtained from Cerilliant^®. Distilled water was processed through a Milli-Q water system (Millipore, Bedford, MA, USA).