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Cd11c cre tg

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The CD11c–Cre-Tg is a transgenic mouse line that expresses Cre recombinase under the control of the CD11c promoter, which is active in dendritic cells. This allows for the conditional deletion or expression of target genes in the dendritic cell population.

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Lab products found in correlation

Myd88, by Jackson ImmunoResearch (2 mentions) Ot 1 cd8 t cell receptor tg, by Jackson ImmunoResearch (2 mentions) Tmem173gt, by Jackson ImmunoResearch (2 mentions) Cd11c itgax dtr, by Jackson ImmunoResearch (2 mentions) Balb c tg mmtv neu, by Jackson ImmunoResearch (2 mentions) Balb c mice, by Charles River Laboratories (2 mentions) Ot 2 tcr tg, by Jackson ImmunoResearch (1 mentions) Ot 2, by Charles River Laboratories (1 mentions) C57bl 6, by Janvier Labs (1 mentions)

4 protocols using cd11c cre tg

1

Murine Hematopoietic Reconstitution Model

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C57BL/6 and B6.CD45.1 mice were obtained from the National Institutes of Health. B7.1/B7.2 DKO (B7 DKO), CD40 KO, B cell KO (IgM KO, μMT), MHCII KO, MHCII(I-Ab)flox/flox, Igha congenic, CD11c-Cre-Tg, CD11c-EGFP-Cre-Tg, CD19-Cre knock-in, and OT-II TCR Tg mice were purchased from Jackson Laboratory. BM chimera mice were generated by reconstitution of 107 total T cell–depleted BM cells from donor mice to irradiated (950 rad) host mice i.v. Mice were maintained in accordance with National Institutes of Health guidelines. All animal experiments were approved by the National Cancer Institute and the National Institute of Allergy and Infectious Diseases Animal Care and Use Committees.
Watanabe M., Fujihara C., Radtke A.J., Chiang Y.J., Bhatia S., Germain R.N, & Hodes R.J. (2017). Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells. The Journal of Experimental Medicine, 214(9), 2795-2810.
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2

Murine Immune Cell Protocols

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Six- to eight-week old female C57BL/6J mice were purchased from Harlan or Jackson laboratory. Six- to eight-week old female Balb/c mice were purchased from Charles River laboratory in China. Myd88−/−, Trif−/−, Tmem173gt, OT-I CD8+ T cell receptor (TCR)-Tg, CD11c–Cre-Tg, CD11c(itgax)-DTR and Balb/c-Tg (MMTV-neu) mice were purchased from The Jackson Laboratory. ifnar1flox/floxmice were kindly provided by Dr. Ulrich Kalinke from the Institute for Experimental Infection Research, Hanover, Germany. All the mice were maintained under specific pathogen free conditions and used between 6–12 weeks of age in accordance to the animal experimental guidelines set by the Institutional Animal Care and Use Committee of the University of Chicago and Institute of Biophysics, CAS.
Liu X., Pu Y., Cron K., Deng L., Kline J., Frazier W.A., Xu H., Peng H., Fu Y.X, & Xu M.M. (2015). CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors. Nature medicine, 21(10), 1209-1215.
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3

Murine Immune Cell Protocols

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Six- to eight-week old female C57BL/6J mice were purchased from Harlan or Jackson laboratory. Six- to eight-week old female Balb/c mice were purchased from Charles River laboratory in China. Myd88−/−, Trif−/−, Tmem173gt, OT-I CD8+ T cell receptor (TCR)-Tg, CD11c–Cre-Tg, CD11c(itgax)-DTR and Balb/c-Tg (MMTV-neu) mice were purchased from The Jackson Laboratory. ifnar1flox/floxmice were kindly provided by Dr. Ulrich Kalinke from the Institute for Experimental Infection Research, Hanover, Germany. All the mice were maintained under specific pathogen free conditions and used between 6–12 weeks of age in accordance to the animal experimental guidelines set by the Institutional Animal Care and Use Committee of the University of Chicago and Institute of Biophysics, CAS.
Liu X., Pu Y., Cron K., Deng L., Kline J., Frazier W.A., Xu H., Peng H., Fu Y.X, & Xu M.M. (2015). CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors. Nature medicine, 21(10), 1209-1215.
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4

Autophagy in Dendritic Cell Development

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Mice strains used in this study are: CD45.1(Charles River, France), C57BL/6 (Janvier), Atg5 flox/flox (Hara et al., 2006) (Pr Mizushima, Tokyo, Japan), CD11c-Cre Tg (Jackson Laboratory), Atg14 flox/flox (Pr Akira, Osaka Japan), OT-II (Charles River Laboratory), Foxp3 RFP RORgt GFP (Mathias Lochner, Hannover Medical School). Atg5 À/À DC mice (Atg5 flox/flox _ CD11-Cre +/À ) and Atg5 +/+ DC (Atg5 flox/flox _ CD11-Cre À/À ) mice were obtained by crossing Atg5 flox/flox mice to CD11-Cre +/À mice. Animals were crossed, bred and housed under specific-pathogen-free conditions in the animal facility of the faculty of Medicine, University of Geneva, Switzerland. Male and female mice ranging from 8-14 weeks of age were used in experiments. Animals were aged and sex matched and assigned to experimental groups, using littermate controls. All animal protocols were approved by the cantonal veterinary office of the canton of Geneva, Switzerland (authorization number GE/103/18 and GE/38/14 and FRM1005-Medicine CMU).
Niven J., Madelon N., Page N., Caruso A., Harlé G., Lemeille S., Seemayer C.A., Hugues S, & Gannagé M. (2019). Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells. Cell reports, 28(1).
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