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Hydrochloric acid 1 n

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Hydrochloric acid (1 N) is a laboratory reagent that is widely used in various scientific applications. It is a clear, colorless solution of hydrogen chloride in water, with a concentration of 1 Normal (N). This product is commonly used in titrations, pH adjustments, and other analytical procedures where a standard strength of hydrochloric acid is required.

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2 protocols using hydrochloric acid 1 n

1

Formulation and Characterization of Lipid-Based Drug Delivery Systems

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Capmul MCM (HLB 4.7) was obtained as a gift from Abitec Corporation (Columbus, OH). The composition of Capmul MCM is approximately 60% of medium-chain monoglycerides and 40% of diglycerides, derived from caprylic acid (83%) and capric acid (17%). Danazol was donated by Sanofi-Aventis Pharmaceutics (Bridgewater, NJ). Caprylic acid (HLB 1), indomethacin, haloperidol, hydrochloric acid (1 N), potassium chloride, potassium phosphate monobasic, sodium hydroxide, sodium acetate, acetic acid, and polyethylene glycol (PEG) 400 were purchased from VWR (Solon, OH). Cremophor RH40 (HLB 14–16) was supplied by BASF Corporation (Tarrytown, NJ). All chemicals and solvents were of analytical purity or high performance liquid chromatography (HPLC) grade and used as received with no further treatment.
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2

Preparation of AAA Stock Solution

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A 120 mg amount of AAA (Lot: BVBG0603V; Sigma-Aldrich Corp., St. Louis, MO, USA) was dissolved in 1 mL hydrochloric acid [1 N] (VWR, Radnor, PA, USA). This AAA stock was diluted to an 80 mM solution using 0.9% sterile normal saline solution and was brought to a pH of 7.4. The final solution was passed through a disposable Millex-GP syringe filter unit with a pore size of 0.22 lm (Batch, MKBL8989; Sigma-Aldrich Corp.) to remove any potential particulates. Solutions were made immediately before use and all solutions remained at room temperature until time of injection.
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