Biograph 64 truepoint pet ct

The PET/CT scans were acquired on a dedicated PET/CT scanner (Siemens Biograph 64 Truepoint PET/CT, Germany). This device merges a PET scanner with a multidetector CT scanner and permits the acquisition of coregistered PET and CT images in a single session. Macaques fasted for 6 h before the injection of 3.7 MBq/kg ¹⁸F‐FDG. Blood glucose (<6 mmol/L) was checked before tracer injection. PET/CT scans were performed after resting for 60 min. A CT scan was obtained initially with a voltage of 120 kV, a current intensity of 60 mA, and a section thickness of 5 mm. PET scans were obtained at 3 min per bed position. PET was performed over the same region immediately after obtaining the CT images. Attenuation correction was performed using CT data, and images were reconstructed as 5 mm slices by applying a standard iterative algorithm. Fused images were converted to DICOM format and analyzed with OsiriX shareware (Geneva, Switzerland) by manually selecting regions of interest (ROIs) of the anterior wall and septal wall of the LV. The SUVmax was calculated using the following formula: SUVmax = radioactivity in ROI (Bq/cm³)/injected dose (Bq)/body weight (g). PET/CT images were analyzed by a skilled radiologist and a qualified nuclear medicine physician.

After anesthetized, the rabbits were immobilized in the supine position with their axis coincidence with the PET scanner in the center of the field (Biograph 64 TruePoint PET-CT: Siemens, Munich, Germany). At 1 h after an ear vein injection of fluorodeoxyglucose ¹⁸F-FDG at a dose of 14.8 MBq/kg, the rabbits received a prone scan for 20 min. The specific parameters were as follows: a slice thickness of 5 mm; 120 kV; 80 mA; and 7 min per bed position. Before 18F-FDG PET/CT scanning, all the selected tumor-bearing rabbits must be fasting for at least 6 h. The standardized uptake values (SUV) were determined.

PET examinations were carried out (immediately prior to and after 14 and 28 days of treatment) using the standard clinical protocol. The first 5 patients (included during 2006 and 2007) were examined with a ECAT EXACT 31 PET camera (CTI, Knoxville, Tenn., USA) and 30 of the subsequent patients with a Biograph 64 Truepoint PET/CT (Siemens Medical Solutions, Erlangen Germany) scanner (during 2008–2011). In the case of two patients from Uppsala University Hospital Discovery ST PET/CT scanner (GE Healthcare) was employed. For each patient all three scans were performed on the same machine.
One hour after intravenous injection of 4 MBq FDG/kg the patients were scanned from the base of their skulls to the proximal aspects of the thighs. They were instructed to fast for at least 6 hours prior to examination and the blood level of glucose was measured routinely. In addition, a low-dose attenuation correction and a full-dose diagnostic CT were performed. Contrast medium was injected intravenously in connection with the baseline and third scan. Assessment was acheived with Siemens True-D Syngo software.