Soybean phosphatidylcholine spc

Manufactured by Merck Group

Sourced in United States

Soybean phosphatidylcholine (SPC) is a naturally-derived lipid compound extracted from soybeans. It serves as a core component in various laboratory applications, providing a source of phospholipids for use in research, formulation development, and analytical procedures.

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Lab products found in correlation

Tween 80, by Merck Group (1 mentions) Mannitol, by Merck Group (1 mentions) Paclitaxel tax, by Merck Group (1 mentions) Xenolight dir, by PerkinElmer (1 mentions) Methyl thiazolyl tetrazolium (mtt), by Merck Group (1 mentions) Cremophor elp, by BASF (1 mentions) Rgd peptide, by GL Biochem (1 mentions) Dimethyldioctadecylammonium bromide ddab, by Merck Group (1 mentions) Compritol 888 ato 888 ato, by Gattefosse (1 mentions)

Close spelling variants of this product

Phosphatidylcholine (107 citations) Soybean phosphatidylcholine (8 citations)

2 protocols using soybean phosphatidylcholine spc

LHRH-Targeted Lipid Nanoparticles for Cancer Therapy

Cited 1 time

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Precirol ATO 5 was generously provided by Gattefossé USA (Paramus, NJ). Soybean phosphatidylcholine (SPC), Paclitaxel (TAX), Squalene, Tween-80, Mannitol were purchased from Sigma Aldrich (St. Louis, MO). DSPE-PEG (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] were obtained from Avanti Polar Lipids (Alabaster, AL). XenoLight DiR obtained from Perkin Elmer (Akron, OH). A modified synthetic analog of Luteinizing Hormone-Releasing Hormone (LHRH) decapeptide (Gln-His-Trp-Ser-Tyr-DLys(D-Cys)-Leu-Arg-Pro) was synthesized according to our design by American Peptide Company, Inc. (Sunnyvale, CA). The sequence of native LHRH peptide, which is similar in human, mouse, and rat, was modified to provide a reactive amino group only on the side chain of a lysine residue, which replaced Gly at the position 6 to yield the superactive, degradation-resistant-Lys-6-des-Gly-10-Pro-9-ethylamide LHRH analog 10 (link)-13 (link). The synthesized sequence of LHRH peptide is highly efficient for targeting of drug delivery systems specifically to the cancer tumors 9 (link), 10 (link), 14 (link)-17 (link) and Cys residue do not influence the recognition process. The remmining materials were obtained from Sigma Aldrich (St. Louis, MO).

Garbuzenko O.B., Kuzmov A., Taratula O., Pine S.R, & Minko T. (2019). Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy. Theranostics, 9(26), 8362-8376.

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Dual-Targeted Nanoparticle Delivery for Cancer Therapy

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RGD peptide was supplied by the GL Biochem Ltd (Shanghai, China). Lf, 2-iminothiolane (Traut’s Reagent), stearic acid, soybean phosphatidylcholine (SPC), dimethyldioctadecylammonium bromide (DDAB), and MTT were purchased from Sigma Aldrich (St Louis, MO, USA). COMPRITOL^® 888 ATO (888 ATO) was generously provided by Gattefossé (Paramus, NJ, USA). Polyoxyl castor oil (Cremophor ELP) was donated by BASF (Ludwigshafen, Germany). Injectable soya lecithin was obtained from Shanghai Taiwei Pharmaceutical Co, Ltd (Shanghai, China). Distearoylphosphatidylethanolamine-polyethylene glycol (MW ~2 kDa)-maleimide (DSPE-PEG₂₀₀₀-MAL) and DSPE-PEG₂₀₀₀-NH₂ were purchased from Xi’an ruixi Biological Technology Co., Ltd (Xi’an, China). VCR was purchased from Shaanxi Pioneer Biotech Co., Ltd (Xi’an, China). TMZ was kindly provided by Laimei Pharmaceutical Co., Ltd (Chongqing, China). All other chemicals were of analytical grade or high-performance liquid chromatography (HPLC) grade and used without further purification.

Zhang J., Xiao X., Zhu J., Gao Z., Lai X., Zhu X, & Mao G. (2018). Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy. International Journal of Nanomedicine, 13, 3039-3051.

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