Lecithin s100 soya lecithin

DTX was supplied by Scino Pharm (Tainan, Taiwan). CIS was purchased from Sigma-Aldrich (St. Louis, MO). PF127 (Kolliphor P407) was obtained from BASF (Ludwigshafen, Germany). Lecithin S100 (soya lecithin) was purchased from Lipoid (Ludwigshafen, Germany). C90 [propylene glycol monocaprylate (type II) NF] was obtained from Gattefosse (Saint Priest, France). All chemicals, solvents, and reagents were of analytical grade. Tynen^® as the solvent-based free DTX was purchased from TTY Biopharm (batch no. STW1508, expiration date: 1 February 2018; Taipei, Taiwan).

QUE and acetic acid were obtained from Sigma-Aldrich (St. Louis, MO, USA). Methanol and acetonitrile were purchased from JT Baker (Center Valley, PA, USA). Fetal bovine serum (FBS) was purchased from Biowest (Nuaillé, France). D-α-Tocopheryl polyethylene glycol succinate (TPGS) was purchased from BASF (Ludwigshafen, Germany). Lecithin S100 (soya lecithin) was purchased from Lipoid (Ludwigshafen, Germany). Matrigel was procured from Becton Drive (Franklin Lakes, NJ, USA). Tween^® 80 was purchased from Merck (Billerica, MA, USA). All reagents used for the high-performance liquid chromatographic (HPLC) analysis, including acetonitrile and methanol, were HPLC grade, and other reagents were analytical grade.