Echinomycin

Manufactured by Fujifilm

Sourced in Japan

Echinomycin is a laboratory equipment product manufactured by Fujifilm. It is a cyclic peptide that functions as a DNA-binding agent, capable of inhibiting DNA replication and transcription processes.

Automatically generated - may contain errors

Lab products found in correlation

U0126, by Fujifilm (1 mentions) Ly294002, by Fujifilm (1 mentions) Syringe filters, by Iwaki (1 mentions)

2 protocols using echinomycin

Echinomycin and PX-478 Preparation

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Echinomycin and PX-478 were obtained from FUJIFILM Wako (Tokyo, Japan) and Selleckchem (Houston, TX, USA), and were dissolved in dimethyl sulfoxide to make stock solutions.

Tsubaki M., Takeda T., Matsuda T., Kimura A., Tanaka R., Nagayoshi S., Hoshida T., Tanabe K, & Nishida S. (2023). Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells. BMB Reports, 56(2), 78-83.

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Preparing Pharmacological Reagents

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Melphalan, echinomycin, U0126, LY294002, and dimethyl fumarate (DMF) were purchased form Wako (Tokyo, Japan). These reagents were dissolved in dimethyl sulfoxide. These reagents were diluted in PBS (0.05 M, pH7.4), filtrated through syringe filters (0.45 μm, IWAKI GLASS, Tokyo, Japan) and used for various assays described below.

Tsubaki M., Takeda T., Tomonari Y., Koumoto Y.I., Imano M., Satou T, & Nishida S. (2019). Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB. Laboratory investigation; a journal of technical methods and pathology, 99(1).

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