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Benzophenone

Manufactured by Merck Group
Sourced in Germany, United States, United Kingdom, Italy, France, Belgium

Benzophenone is a chemical compound used as a versatile reagent and intermediate in various organic synthesis reactions. It is a crystalline solid with a distinctive aromatic odor. Benzophenone serves as a precursor for the production of other chemical compounds and is utilized in a range of applications, including research and development, and various industrial processes.

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80 protocols using benzophenone

1

UV-Cured PDMS Substrate Fabrication

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The PDMS mixture was prepared using commercially available Sylgard 184 (Dow Corning) with the base: curing agent mass ratio of 10:1. Next, it was admixed with benzophenone (Sigma-Aldrich) at the mass ratio of 1:100 benzophenone: PDMS dissolved in xylene (200 mg/ml, POCH Gliwice), and degassed.
The PDMS substrates were prepared on the 25 mm round coverslip glass using a spin-coating technique, resulting in PDMS films with thickness of ~60 μm. The spinning speed was 500 rpm. Then, a fraction of substrates was exposed to UV light (400 W mercury lamp) for times ranging from 0 to 5 h. The irradiated and non-irradiated substrates were baked for 15 min at 150 °C.
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2

Synthesis of NIPAAm Hydrogels

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N-isopropylacrylamide (NIPAAm) (97%) was purchased from Sigma (Taufkirchen, Germany). Tetramethylethylenediamine (TEMED), ammonium persulfate (APS), N,N′-methylenebisacrylamide (MBA), 1,3,5-benzenetricarbonyltrichloride (TMC, 98%), n-hexane, p-phenylenediamine (PPD, 99%), triethylamine (TEA, 99.5%), polyethylene glycol (PEG-600), benzophenone, sodium chloride (NaCl,) propanol, and ethanol were obtained from Merck (Steinheim am Albuch, Germany).
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3

Dye-Sensitized Solar Cell Fabrication

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Activated carbon (AC, P4) was provided by SGL Carbon (Germany). Sodium carboxymethyl cellulose (CMC, Walocell CRT 2000) was purchased from Dow Wolff Cellulosics. Conductive carbon (CC, Super C65) was purchased from Imerys Graphite & Carbon. The ionic liquid Pyr14TFSI (99.9%, Solvionic) was dried under high vacuum (10−7 mbar) for 24 h at 120°C. Its water content after drying, determined by Karl Fischer titration (Mettler Toledo), was below 10 ppm. Benzophenone (for synthesis, ≥99.0%, Merck) was dried under vacuum for 48 h at 40°C. Poly(ethylene oxide) (PEO, Mv = 100,000, Dow Chemical) was dried under vacuum for 48 h at 50°C. The sensitizing dye, cis-bis(isothiocyanato)(2,2'-bipyridyl-4,4'-dicarboxylato)(4,4'-di-nonyl-2'bipyridyl) ruthenium (II) (Z907, Ruthenizer 520-DN) was purchased from Solaronix. TiO2 Paste DSL 18NR-AO was purchased from Dyesol. The Meltonix 1170-60 (60 μm) sealant was purchased from Solaronix. Solar cells electrolyte components, sodium iodide (NaI) and iodine (I2) were purchased from Sigma-Aldrich (Milan, Italy). 4-tert-butylpyridine (TBP) and methoxypropionitrile (CH3OCH2CH2CN) were purchased from Merck. 7 Ω sq−1 sheet resistance fluorine-doped tin oxide (FTO)-coated glass was purchased by Solaronix.
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4

Synthesis of Functionalized Compounds

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Standards: isatine, benzoic acid, 2-nitrophenol, diphenylamine were purchased from POCH (Avantor Performance Materials Poland S.A.), 3,4-dichloroaniline, 2,4-dichloroaniline, benzophenone from MERCK, diphenylmethane from Koch-Light. 3,4-Dichloroacetanilide was synthesized from 3,4-dichloroaniline and acetic anhydride. All reagents and chemicals were analytical purity grade.
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5

Organic Synthesis Reagents Characterization

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Octamethylcyclotetrasiloxane (D4) (Denge Kimya, >95%), tetramethyldisiloxane (TMDS) (Denge Kimya, >95%), diphenyl iodonium hexafluorophosphate (DPI) (Aldrich, 98%), benzophenone (Merck, 99%), pyrene (Aldrich, 98%), and methanol (99.8%, Merck) were used as purchased. Dichloromethane (ISOLAB Chemicals, ≥99 %) (DCM) was purified by conventional drying and distillation methods.
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6

Synthesis and Characterization of Magnesium-Sodium Heterobimetallic Complex

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Unless stated otherwise, all
of the experiments were conducted using standard Schlenk line and/or
glovebox techniques under an inert atmosphere of argon. NMR spectra
were recorded with an Agilent ProPulse spectrometer (1H
at 500 MHz, 13C at 126 MHz). The spectra are referenced
relative to residual protio solvent resonances. Elemental analyses
were performed at Elemental Microanalysis Ltd., Okehampton, Devon,
UK. Solvents were dried by passage through a commercially available
solvent purification system and stored under argon in ampules over
4 Å molecular sieves. C6D6 was purchased
from Sigma-Aldrich and dried over a potassium mirror before distilling
and storage over molecular sieves. {CH2SiMe2N(H)Dipp}2 and [{SiNDipp}MgNa]2 (4) were synthesized according to literature procedures.33a ,36 (link) Benzophenone and TEMPO were purchased from Merck and purified by
sublimation prior to usage. All other chemicals were purchased from
Merck and used as received.
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7

Synthesis of Organic Compounds via Aldehyde Coupling

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All reagents such as butyraldehyde, dodecanal, octanal, hydro cinnamaldehyde, benzaldehyde, furfural, nitromethane, 1,1,3,3-tetramethylguanidine, nichel chloride hexahydrate (NiCl2.6H2O), sodium borohydride (NaBH4), ethanolamine, sodium acetate (NaOAc), cerium trichloride heptahydrate (CeCl3.7H2O), sodium iodide (NaI), isophorone diisocyanate (IPDI), PEG 400, 2-hydroxyethyl methacrylate (HEMA), benzophenone and N-methyl diethanolamine were all purchased from Merck. Polyethylene terephthalate (PET) are 2–5 mm particle size pellets obtained by crushing PET bottle scraps. As the first treatment, diols and diisocyanate were dried at 50°C under vacuum conditions for 24 h to remove residual water, and all the aldehydes were previously distilled. In the case of air and moisture-sensitive reactions, the glassware was oven dried at 100°C for more than 2 hours before use, when the reactions were performed under an inert atmosphere (nitrogen gas). For thin-layer chromatography (TLC) analysis, Merck pre-coated TLC plates (silica gel 60 GF254 0.25 mm) were used. Products were observed under UV light or stained in 2,4-dinitrophenyl hydrazine or potassium permanganate solutions.
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8

Quantitative Analysis of Cinnarizine and DMH

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Cinnarizine pure sample was obtained as a gift from Amoun Pharmaceuticals (Cairo, Egypt) with a purity of 100.26% according to the analysis results of the reported method,45 DMH was kindly supplied from Kahira Pharmaceuticals and Chemical Industries Company (Cairo, Egypt) with a purity of 99.10% according to the reported method.45 Benzophenone and DPP were purchased from Sigma Aldrich, Chemie GmbH (Darmstadt, Germany) with claimed purity of 97% and 99%, respectively according to the manufacturing certificates of analysis. Methanol, ethanol, acetone, hexane, methylene chloride, chloroform, and ethylacetate were of HPLC grade (Fisher, Loughborough, UK) and were purchased from Sigma Aldrich Chemie GmbH (Darmstadt, Germany). Orthophosphoric acid, glacial acetic acid, formic acid, triethylamine, and ammonia solution (33%) were bought from EL-Nasr pharmaceutical, Chemical Co., Abu Zabaal, Cairo, Egypt and were of analytical grade. Amocerebral® tablets, (batch no. 6221025030658) were manufactured by Amoun pharmaceutical company (Cairo, Egypt) each tablet was labeled to contain 20 mg of DMH and 10 mg of CIN.
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9

Quantitative Analysis of DMH and CIN

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Dimenhydrinate sample was kindly supplied by Kahira Pharmaceuticals and Chemical Industries Company (Shoubra, Cairo, Egypt) with a purity of 99.10% according to the reported method.35 (link) Cinnarizine pure sample was obtained as a gift from Amoun Pharmaceuticals (El Obour City, Cairo, Egypt) with a purity of 100.26% according to the reported method.35 (link) Benzophenone and DPP were bought from Sigma Aldrich, Chemie GmbH (Darmstadt, Germany) with a purity of 97% and 99%, respectively according to the manufacturing certificates of analysis. Methanol and acetonitrile were of HPLC grade (Fisher, Loughborough, UK) and were purchased from Sigma Aldrich Chemie GmbH (Darmstadt, Germany). Orthophosphoric acid, sodium lauryl sulphate (SLS) and potassium dihydrogen phosphate were purchased from EL-Nasr Pharmaceutical, Chemicals Co., Abu Zabaal, Cairo, Egypt and were of analytical grade. Amocerebral® tablets (batch no. 6221025030658) were manufactured by Amoun Pharmaceutical Company (Cairo, Egypt), each tablet was labeled to contain 20 mg of DMH and 10 mg of CIN.
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10

Polyethylene Nanocomposite Formulation

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High-purity surrogates (biphenyl, benzophenone, methyl stearate and octabenzone) were provided by Sigma-Aldrich (Saint-Louis, MO, USA). Linear low density polyethylene (grade LL 1002YB, melt flow index of 2.0 g/10 min, density of 0.918 g·cm−3), supplied by Exxon Mobil Chemical (Irving, TX, USA), was chosen as the polymer matrix (labelled “PE” in the present work). Clay was provided as a 40%-loaded masterbatch also based on linear low density polyethylene. The organically modified montmorillonite was Nanomer I44P (containing 38% dimethyl dialkyl (C14-18) Ammonium as checked by thermogravimetric analyses) from Nanocor (Hoffman Estates, IL, USA). The mineral content of the masterbatch was measured at 23.5% using TGA.
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