Aquarius control ena

Gelatin (porcine, type A) was generously provided by Medana Pharma (Sieradz, Poland), Aquacoat CPD^® (FMC Biopolymer, Philadelphia, PA, USA), a 30% aqueous pseudolatex dispersion of cellulose acetate phthalate (CAP) and cellulose acetate propionate (CAP 482-0.5), cellulose acetate butyrate (CAB 381-0.5) (Eastman Chemical, Kingsport, TN, USA), hypromellose phthalate (HPMCP(HP-55), hypromellose acetate succinate (HPMCAS) (Aqoat AS-MF and AS-HF, Shin-Etsu, Tokyo, Japan) were gifts from IMCD Polska (Warsaw, Poland). Eudragit L30 D-55, Eudragit L100, and Acryl Eze II (Evonik, Essen, Germany) were obtained from Evonik. Opadry Enteric (Colorcon, Budapest, Hungary) was provided by Colorcon. Aquarius Control ENA (Ashland, Covington, KY, USA) was received from Ashland. Glycerol (99.5%) was purchased from Chempur (Piekary Śląskie, Poland), polyethylene glycol (PEG-400), sorbitol, ί-carrageenan, gellan, and xanthan were purchased from Sigma Aldrich (Saint Louis, MO, USA). The compositions of certain complex products are specified further in Table 1.

Diclofenac sodium (Amoli Organics, Mumbai, India). Inert cores: calcium phosphate-based (DCPA) pellets—PharSQ^® Spheres CM M (Chemische Fabrik Budenheim, Budenheim, Germany), microcrystalline cellulose pellets—VIVAPUR^® MCC Spheres 500 (JRS Pharma, Rosenberg, Germany), sugar spheres—pharm-a-spheres^TM MESH 35-25 (Hanns G. Werner GmbH, Tornesch, Germany), isomalt starter pellets—galenIQ^TM 960 (BENEO-Palatinit GmbH, Mannheim, Germany). Film coating systems: Vivacoat^® FM-1M 000 (JRS Pharma, Rosenberg, Germany), Aquarius^® Control ENA (Ashland, Covington, KY, USA), Eudragit^® RL30D and Eudragit^® RS30D (Evonik, Darmstadt, Germany). Transparent hard gelatin capsule shells, size “00” (Pharmapol Arzneimittelvertrieb GmbH, Dägeling, Germany). DicloDuo^® 75 mg, modified-release capsules (Pharmaswiss Česká republika s.r.o., Praha, Czech Republic).