Rats were randomly divided into four groups of 10. Group I: healthy normal control group that received 0.5 mL saline by injection for 4 weeks; Group II: CP control that received intraperitoneal CP (Baxter Oncology, USA, 65 mg/kg/day) for 4 weeks; Group III: triptorelin (Decapeptyl, 1 mg) control that received subcutaneous triptorelin (Ferring, Switzerland, 0.05 mg/kg/day) for 4 weeks; and Group IV: triptorelin-treated group that received intraperitoneal CP (65 mg/kg/day) and subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks. The rats were anesthetized by inhalation of pentobarbital overdose (200 mg/kg) followed by rapid cervical dislocation and decapitation. This was followed by harvesting of brain tissues, which were placed in 10% formaldehyde.
Shaibah H.S., Elsify A.E., Medhat T.M., Rezk H.M, & El-Sherbiny M. (2015). Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide. Journal of Microscopy and Ultrastructure, 4(3), 123-132.
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