Anti inpp4b

Manufactured by Santa Cruz Biotechnology

Sourced in United States

Anti-INPP4B is a laboratory reagent used for the detection and quantification of INPP4B, a phosphoinositide 4-phosphatase enzyme involved in cellular signaling pathways. This product is designed for research use only and its core function is to provide a tool for the study of INPP4B expression and function in biological systems.

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Lab products found in correlation

Close spelling variants of this product

INPP4B

2 protocols using anti inpp4b

Signaling Pathway Antibody Validation

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Antibodies against P70S6K, pP70S6K (T389), 4EBP-1, p4EBP-1 (S65), eIF4E, eIF4G, cyclinD1, AKT, and SGK3 were obtained from Cell Signaling Technology (Beverly, MA, USA). Anti-INPP4B and anti-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). The antibody against HPIP was obtained from Proteintech (Chicago, IL, USA). RAD001 and 4EGI-1 were purchased from Selleck (Houston, TX, USA) and Calbiochem (Darmstadt, Germany), respectively.

Ruan X.H., Liu X.M., Yang Z.X., Zhang S.P., Li Q.Z, & Lin C.S. (2019). INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation. OncoTargets and therapy, 12, 3109-3117.

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Antibody Reagents for Signaling Pathways

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Anti-Akt (#4685), anti-phospho-Akt S473 (#4060), anti-phospho-Akt T308 (#9275), anti-Cyclin E (#4129), anti-GSK3β (#9315), anti-phospho-GSK3β (#9336), anti-NDRG1 (# 5196), anti-phospho-NDRG1 (#3217), anti-p110α (#4249), anti-S6K (#2705), anti-pS6K T389 (#9205), anti-SGK3 (#8156), anti-Vps34 (#4263) and anti-β-actin (#4970) were purchased from Cell Signaling Technologies. Anti-FLAG M2 (#F3165) was from Sigma-Aldrich. anti-SGK3 pT320 (# S1010-85W8) was from US Biologicals. Anti-GFP (# sc-9996), anti-GST (# sc-459) and anti-INPP4B (#sc-12318) were from Santa Cruz. Anti-Fbw7 (#A301–720A) was from Bethyl Laboratories. anti-SGK3 (#LS-C132061) for immunoprecipitation was from LifeSpan BioSciences. Anti-HA was generated and purified from the 12CA5 hybridoma. Anti-p85, generated in house, has been described. Horseradish peroxidase-conjugated anti-goat was from Millipore. Horseradish peroxidase-conjugated anti-rabbit and anti-mouse immunoglobulin G antibodies were from Chemicon.

Gasser J.A., Inuzuka H., Lau A.W., Wei W., Beroukhim R, & Toker A. (2014). SGK3 mediates INPP4B-dependent PI 3-Kinase signaling in breast cancer. Molecular cell, 56(4), 595-607.

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