Isoliquiritigenin

Manufactured by Cayman Chemical

Sourced in United States

Isoliquiritigenin is a chemical compound that can be used in laboratory research and analysis. It is a flavonoid derived from licorice root. The core function of Isoliquiritigenin is to serve as a reference standard and research tool for scientific investigations.

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2 protocols using isoliquiritigenin

Comparative Analysis of Phytochemical Effects on ER Stress

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The H9c2 rat cardiomyoblast cell line was purchased from ATCC (n° CRL-1446, Manassas, VA, USA). Cells were cultured in DMEM medium with 1 mM pyruvate and 4.5 g/L glucose (Fisher Scientific, Illkirch, France) and supplemented with 100 U/mL penicillin, 100 mg/mL streptomycin (Fisher Scientific, Illkirch, France), and 10% FBS (Corning, Glendale, AZ, USA) at 37 °C under 5% CO₂/95% air. Severe ER stress was induced by TN treatment at 10 µg/mL (Tocris, Bristol, UK). EX-527 Sirtuin-1 inhibitor was used at 5 µM (Tocris, Bristol, UK). Its IC50 value was determined using the in vitro Fluor de Lys deacetylation assay and a purified human SIRT1 range from 38 to 150 nM. Berberine, Catechin, Ferulic Acid, Malvidin, Tyrosol, and Resveratrol were purchased from Merck-Sigma (Saint-Quentin-Fallavier, France). Butein, Isoliquiritigenin, Piceatannol, and Pterostilbene were purchased from Cayman (Ann Arbor, MI, USA). All phenolic phytochemicals were diluted in DMSO.

Monceaux K., Gressette M., Karoui A., Pires Da Silva J., Piquereau J., Ventura-Clapier R., Garnier A., Mericskay M, & Lemaire C. (2022). Ferulic Acid, Pterostilbene, and Tyrosol Protect the Heart from ER-Stress-Induced Injury by Activating SIRT1-Dependent Deacetylation of eIF2α. International Journal of Molecular Sciences, 23(12), 6628.

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Peroxisome Proliferator-Activated Receptor Agonists and Antioxidants

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Peroxisome proliferator-activated receptor (PPAR) agonists fenofibrate, troglitazone, bezafibrate, 15-deoxy-Δ^12,14-Prostaglandin J₂ (PGJ2), ciglitazone, rosiglitazone, pioglitazone, and MCC-555 were from Cayman Chemical (Ann Arbor, MI, USA). Antioxidants 2,2,5,7,8-Pentamethyl-6-chromanol (PMC), 4-hydroxy-TEMPO (TEMPO, a superoxide dismutase mimic) and Tiron were from Sigma (St. Louis, MO), MCI-186 (MCI), Trolox and DL-a-lipoic acid (lipoic acid) were from Cayman Chemical, N-Acetyl-L-cysteine (NAC) was from Abcam (Cambridge, MA), and elamipretide (ELAM) was from Muse Chem (Fairfield, NJ). Trolox amide analogs (669, 738, 829) were from ChemBridge (San Diego, CA). Inflammasome inhibitors MCC950 and Isoliquiritigenin were from Cayman Chemical. The NADPH-oxidases inhibitor apocynin (APO) was from Abcam and diphenyleneiodonium (DPI) was from Sigma.

Gnanaguru G., Mackey A., Choi E.Y., Arta A., Rossato F.A., Gero T.W., Urquhart A.J., Scott D.A., D’Amore P.A, & Ng Y.S. (2021). Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL–induced retinal pigment epithelial cell death as a potential pharmacotherapy. Free radical biology & medicine, 178, 360-368.

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