Selumetinib
Selumetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), a key component in the RAS/RAF/MEK/ERK signaling pathway. It is a powder-form laboratory reagent used in research and development applications.
Lab products found in correlation
134 protocols using selumetinib
Fibroblast-Melanoma Crosstalk Modulation
Investigating Stress Response Signaling Pathways
Inhibitors, major targets and concentrations used in this study.
Inhibitor | Major target(s) | Concentration | Reference |
---|---|---|---|
GSK2656157 | PERK | 50 and 500 nM | [42 (link)] |
pictilisib (GDC-0941) | PI3K | 500 nM | [43 (link)] |
AKT inhibitor VIII | AKT PH domain | 5 μM | [44 (link)] |
AZD8055 | MTOR | 500 nM | [45 (link)] |
apitolisib (GDC-0980) | PI3K and MTOR | 500 nM | [46 (link)] |
selumetinib (AZD6244) | MEK1 | 50 nM | [47 (link)] |
GDC-0879 | BRAF/CRAF | 50 nM | [48 (link)] |
RO5126766 | BRAF/CRAF/MEK | 50 nM | [49 (link)] |
SCH772984 | ERK1/2 | 50 nM | [50 (link)] |
Isolation and Culture of Mouse Cortical Neurons
Preparation of Inhibitor Stock Solutions
MEKi Culturing of Naive hESCs
Chemical Procurement for Research
Inhibition of Receptor Tyrosine Kinases
Selumetinib Efficacy in KRAS-Driven Tumors
Establishment and Characterization of Entrectinib-Resistant Cell Line
Entrectinib was provided by Ignyta, Inc./F.Hoffmann-La Roche Ltd. Crizotinib, ceritinib, lorlatinib and selumetinib were purchased from Selleckchem. All drugs were dissolved at a 10 mM concentration in dimethyl sulfoxide (DMSO) and stored in small aliquots at −20 °C until further use. Antibodies specific for p-ROS1 (Tyr1068), ROS1, p-AKT (Ser473), AKT, p-ERK1/2 (Thr202/Tyr204), ERK1/2, p-STAT3 (Tyr705), STAT3, p-p53 (Ser15), p53, p-H2AX (Ser139), H2AX and PARP were obtained from Cell Signaling Technologies. Anti-FGF3 and β-actin antibodies were obtained from Santa Cruz Biotechnology.
Selumetinib Inhibits Tumor Growth in LLC Mouse Model
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