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Resomer rg 504

Manufactured by Boehringer Ingelheim
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Sourced in Germany

Resomer® RG 504 is a biodegradable polymer material developed by Boehringer Ingelheim. It is a copolymer of lactic acid and glycolic acid. Resomer® RG 504 is designed for use in various biomedical applications.

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Lab products found in correlation

Taurocholic acid sodium salt hydrate, by Merck Group (1 mentions) Dodecanethiol, by Merck Group (1 mentions) Chloroauric acid, by Merck Group (1 mentions) Sodium citrate tribasic dehydrate, by Merck Group (1 mentions) Phosphotungstic acid hydrate, by Merck Group (1 mentions) Sodium cholate, by Merck Group (1 mentions) Ethyl acetate acs reagent, by Merck Group (1 mentions) Resomer r202h, by Boehringer Ingelheim (1 mentions) Methylene chloride ch2cl2, by Merck Group (1 mentions) Cellulose dialysis membrane, by Merck Group (1 mentions) Poly e caprolactone, by Merck Group (1 mentions) Polyvinyl alcohol (pva), by Merck Group (1 mentions)

3 protocols using resomer rg 504

1

Polymer Nanoparticle Synthesis and Characterization

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The following chemicals were obtained from commercial suppliers and used as received: the polymer poly(d,l-lactic-co-glycolic acid) 50 : 50 (PLGA; MW 38 000–54 000 Da, Tg 46–50 °C), under the commercial name of Resomer® RG 504 was purchased from Boehringer Ingelheim (Ingelheim, Germany) and Evonik Industries (Evonik Röhm GmbH, Germany). Sodium cholate, chloroauric acid (HAuCl4·3H2O), sodium citrate tribasic dehydrate ≥99.0% (Na3C6H5O7·2H2O), PVA (polyvinyl alcohol) MW 85 000–124 000 Da, 97–99% hydrolyzed, taurocholic acid sodium salt hydrate ≥95% (TLC), ethyl acetate ACS reagent, dodecanethiol, phosphotungstic acid hydrate as a contrast agent for microscopy and fluorescent molecule pyrene ≥99.0% were purchased from Sigma Aldrich (St Louis, MO, USA).
Luque-Michel E., Larrea A., Lahuerta C., Sebastian V., Imbuluzqueta E., Arruebo M., Blanco-Prieto M.J, & Santamaría J. (2015). A simple approach to obtain hybrid Au-loaded polymeric nanoparticles with a tunable metal load †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06850a Click here for additional data file.. Nanoscale, 8(12), 6495-6506.
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2

Biodegradable PLGA Polymer Formulations

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Poly(D,L-lactide-co-glycolide) (PLGA) 50:50 Resomer ® RG 504 (Mw 40-50 kDa; ester terminated), poly(D,L-lactide) Resomer ® R 202 H (Mw 10-18 kDa; acid terminated) and poly(D,L-lactide)
Resomer ® R 202 S (Mw 10-18 kDa; ester terminated) were supplied by Boehringer Ingelheim (Ingelheim, Germany). Prior to use, the polymer was dried under vacuum for 24 h to eliminate traces of moisture. Ketoprofen (KET) was kindly provided by Bidachem SpA (Bergamo, Italy), while methylene chloride (CH2Cl2) was supplied by Sigma-Aldrich (Milan, Italy).
Blasi P., Casagrande S., Pedretti A., Fioretto D., Vistoli G, & Corezzi S. (2020). Ketoprofen poly(lactide-co-glycolide) physical interaction studied by Brillouin spectroscopy and molecular dynamics simulations. International journal of pharmaceutics, 580.
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3

Encapsulation of Uncaria tomentosa Extract

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Uncaria tomentosa dried extract (4.5% of total pentacyclic oxindole alkaloids) was kindly donated by Herbarium Laboratório Botânico (PR, Brazil). Poly-e-caprolactone (PCL; Mw 70,000-90,0000 g/mol), polyvinyl alcohol (PVA; Mw 31,000-50,000 g/mol, 87-89% hydrolyzed) and cellulose dialysis membranes (flexible tube type, 33 mm, 14 kDa MWCO) were obtained from Sigma-Aldrich (MO, USA). Poly-d,l-lactide-coglycolide (PLGA), with 50:50 D,L-lactide:glycolide molar ratio and intrinsic viscosity of 0.45-0.60 dl/g (Resomer® RG 504), was purchased from Boehringer Ingelheim (RP, Germany) and poloxamer 188 (Lutrol® F68, Mw 7680-9510 Da) from BSAF (RP, Germany). Methylene chloride, ethyl acetate, acetone and ethanol were acquired from Tedia Brazil (RJ, Brazil).
Ribeiro A.F., Santos J.F., Mattos R.R., Barros E.G.O., Nasciutti L.E., Cabral L.M, & Sousa V.P. (2020). Characterization and in vitro antitumor activity of polymeric nanoparticles loaded with Uncaria tomentosa extract. Anais da Academia Brasileira de Ciencias, 92(1).
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