3 chloro 1 2 propanediol

All reagents and solvents were used without further purification. 3,4-dimethoxythiophene was purchased from Matrix scientific. 3,4-Ethylenedioxythiophene (EDOT), 3-chloro-1,2-propanediol, p-toluene sulfonic acid monohydrate, toluene, tetrahydrofuran (THF), hexane, 3-mercaptopropionic acid (MPA), 2,2-Dimethoxy-2-phenylacetophenone (DMPA), Sodium Hydroxide (NaOH), Potassium hydroxide (KOH), Tris(2-carboxyethyl) phosphine hydrochloride (TCEP), Methanol (MeOH) and dichloromethane were purchased from Sigma. Potassium tert-butoxide (tBuOK) was purchased from ACROS. Ethanol (EtOH) was purchased through Fisher. Aptamer 5′-HS-(CH2)6-AGACAAGGAAAATCCTTCAATGAAGTGGGTCG-(CH2)7-MB-3′ with a 5′ thiol group as covalent linkage site and 3′ methylene blue (MB) as electrochemical reporter was purchased through Biosearch Technologies, Inc., Platinum/Iridium wires were purchased from A-M systems.

Copper(II) sulfate pentahydrate (CuSO₄·5H₂O), sodium tetrachloroaurate(III) dihydrate (NaAuCl₄·2H₂O), iron(III) chloride hexahydrate (FeCl₃·6H₂O), iron(II) chloride tetrahydrate (FeCl₂·4H₂O), silicon dioxide (SiO₂), (3-glycidyloxypropyl)trimethoxysilane, polyvinylpyrrolidone (PVP, MW ~ 10,000), imidazole, propargyl bromide, chlorodiphenylphosphine, sodium borohydride (NaBH₄), methyl orange (MO), sodium azide, 3-chloro-1,2-propanediol, ascorbic acid, rhodamine B (RhB), nitro compounds, methyl red (MR), and tetracycline (TC) were purchased from Sigma-Aldrich, Acros and Merck MilliporeSigma.