5 methylindole

Manufactured by Merck Group

5-methylindole is a chemical compound used in various laboratory applications. It serves as a precursor and intermediate in the synthesis of other chemical compounds. The core function of 5-methylindole is to facilitate and enable specific chemical reactions and processes within the laboratory setting.

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Lab products found in correlation

2 protocols using 5 methylindole

Characterization of Indole Derivatives

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Example 3

General information: ¹H NMR spectra were recorded on a Bruker Avance III600 instrument, in deuterated solvents and were referenced to TMS (6 scale). Flash chromatography was performed on Merck silica gel 60 (0.040-0.063 mm). Analytical thin layer chromatography (TLC) was carried out on precoated (0.25 mm) Merck silica gel F-254 plates. Mass spectra were recorded with a LTQ Orbitrap Discovery instrument, possessing an Ionmax ionization source. 3-Acetoxyindole, 5-bromoindole, 6-chloroindole, 5-cyanoindole, methyl indole-5-carboxylate, methyl indole-6-carboxylate, 5-methylindole, iodine, potassium iodide, thiophenol, oxalyl chloride, anhydrous aluminum chloride, hydroxylamine hydrochloride, anhydrous pyridine, triethylamine, 1,2-dibromoethane, piperazine and morpholine were purchased from Sigma-Aldrich. Anhydrous dichloromethane and anhydrous N,N-dimethylformamide were purchased from Acros organics.

US11213510B2. Thioindirubins (2022-01-04). City of Hope [US], National and Kapodistrian University of Athens [GR]. Inventors: Sangkil Nam [US], David Horne [US], Ravi Salgia [US], Alexios Leandros Skaltsounis [GR], Nicolas Gaboriaud-Kolar [GR], Panagiotis Gerolymatos [GR], Nikolaos Lougiakis [GR].

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Optimization of X. eapokensis Growth

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X. eapokensis was grown in liquid SF-900 II SFM (Thermo Fisher Scientific) in presence of 2% Amberlite^™ XAD-16 (Sigmal Aldrich) or SF-900 supplemented with 1 mM of 2-amino-3-chlorobenzoic acid, 2-amino-5-chlorobenzoic acid, 2-amino-3-methylbenzoic acid, 2-amino-5-methylbenzoic acid, 2-amino-3-methoxybenzoic acid, 2-amino-5-methoxybenzoic acid, anthranilic acid, 3-hydroxy anthranilic acid, 3-methyl proline, 3-benzyl proline, or 4-hydroxy proline, pipecolic acid, and 2 mM of 5-fluoro indole, 5-phenyl indole, or 5-methyl indole and 3 mM of 7-azaindole (all chemicals were purchased from Sigma Aldrich). The cultures were cultivated at 30°C for three days with a starting OD₆₀₀ of 0.1 and cultures were extracted as described below.

Wolff H, & Bode H.B. (2018). The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis. PLoS ONE, 13(3), e0194297.

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