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Atenolol

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Atenolol is a beta-blocker, which is a type of laboratory equipment used to measure and analyze the effects of compounds on biological systems. It is a commonly used tool in the field of medicinal chemistry and pharmacology research.

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Lab products found in correlation

Ofloxacin, by MedChemExpress (2 mentions) Lamotrigine, by MedChemExpress (2 mentions) Digoxin, by MedChemExpress (2 mentions) Carbamazepine, by MedChemExpress (2 mentions) Propranolol, by MedChemExpress (2 mentions) Diltiazem, by MedChemExpress (2 mentions) Quinidine, by MedChemExpress (2 mentions) Fexofenadine, by Tokyo Chemical Industry (2 mentions) Antipyrine, by MedChemExpress (2 mentions) Memantine, by MedChemExpress (1 mentions) Gabapentin, by MedChemExpress (1 mentions) Bq900 slit lamp, by Haag-Streit (1 mentions) Ici 118 551, by MedChemExpress (1 mentions) Carvedilol, by MedChemExpress (1 mentions) Ganciclovir, by MedChemExpress (1 mentions) Pemetrexed, by MedChemExpress (1 mentions) Citalopram, by MedChemExpress (1 mentions) Sumatriptan, by Tokyo Chemical Industry (1 mentions) Acetaminophen, by Merck Group (1 mentions)

4 protocols using atenolol

1

Comparative Physicochemical Characterization

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In this study, 14 compounds with different physiochemical properties were selected. Antipyrine, ofloxacin, lamotrigine, digoxin, quinidine, atenolol, carbamazepine, propranolol, diltiazem, memantine, diphenhydramine, pyrilamine, and gabapentin were purchased from MedChemExpress (Monmouth Junction). Fexofenadine was purchased from Tokyo Chemical Industry. The other chemicals and reagents were of the HPLC grade or better.
Wang S., Chen C., Guan C., Qiu L., Zhang L., Zhang S., Zhou H., Du H., Li C., Wu Y., Chang H, & Wang T. (2021). Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology Research & Perspectives, 9(5), e00879.
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2

Corneal Epithelial Wound Healing Assay

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The mice were systemically anesthetized with pentobarbital sodium (50 mg/kg, ip) and topically anesthetized with 2% xylocaine. Then, the corneal epithelium was marked with 2.5 mm or 3.0 mm trephine and scraped with Alger Brush II corneal rust ring remover (Alger Co., Lago Vista, TX). Ofloxacin was used to prevent postoperative infection. The experimental groups unceasingly received eye drops containing 5 mg/mL of levobunolol (MedChemExpress, Princeton, NJ), atenolol (MedChemExpress) or ICI 118, 551 (MedChemExpress) for 4 times a day and mice received saline as vehicle control. The defects of corneal epithelium were visualized every 12 h by staining with fluorescein sodium and photographed with BQ 900 slit lamp (Haag-Streit, Bern, Switzerland). The experiment was carried out including five mice for each group and repeated at least three times. The defect area was analyzed by Image J software [28 (link)].
Yuan X., Ma X., Yang L., Zhou Q, & Li Y. (2021). β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells. BMC Ophthalmology, 21, 419.
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3

Evaluation of Beta-Blocker Compounds

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Pindolol, carvedilol, carteolol,
atenolol, and ±bisoprolol were purchased from MedChemExpress
(MCE, Monmouth Junction, NJ).
Puhl A.C., Mottin M., Sacramento C.Q., Tavella T.A., Dias G.G., Fintelman-Rodrigues N., Temerozo J.R., Dias S.S., Ramos P.R., Merten E.M., Pearce K.H., Costa F.T., Premkumar L., Souza T.M., Andrade C.H, & Ekins S. (2022). Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors. ACS Omega, 7(32), 27950-27958.
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4

Physicochemical Characterization of Diverse Compounds

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In all, 18 compounds with different physiochemical properties were selected for this study. Antipyrine, ganciclovir, ofloxacin, 4‐aminoAntipyrine, lamotrigine, theophylline, citalopram, digoxin, quinidine, pemetrexed, atenolol, carbamazepine, propranolol, and diltiazem were purchased from MedChemExpress (Monmouth Junction). Acetaminophen was purchased from Sigma‐Aldrich. Fexofenadine and sumatriptan were purchased from Tokyo Chemical Industry. Cimetidine was purchased from National Institute for the Control of Pharmaceutical and Biological Products. All the other chemicals were of the HPLC grade or better.
Chen C., Zhou H., Guan C., Zhang H., Li Y., Jiang X., Dong Z., Tao Y., Du J., Wang S., Zhang T., Du N., Guo J., Wu Y., Song Z., Luan H., Wang Y., Du H., Zhang S., Li C., Chang H, & Wang T. (2020). Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats. Pharmacology Research & Perspectives, 8(2), e00575.
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